Measurement of absolute flow velocity vector using dual-angle, delay-encoded Doppler optical coherence tomography

Pedersen, Cameron J.; Huang, David; Shure, M. A.; Rollins, Andrew M.

doi:10.1364/ol.32.000506

Cited by 62 publications

(36 citation statements)

References 11 publications

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“…By delaying a part of the beam with a glass plate (e.g. Pedersen et al [5]), the two components with different angles can be detected individually. By aligning the incidence plane with the blood vessel, absolute velocity values can be achieved.…”

Section: Introductionmentioning

confidence: 99%

Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes

Doblhoff-Dier¹,

Schmetterer²,

Vilser³

et al. 2014

Biomed. Opt. Express

100

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Abstract:We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the validity of the measurements. In accordance with Murray's law, the log-log regression coefficient between vessel diameter and blood flow was found to be ~3. The blood's velocity scaled linearly with the vessel diameter at higher diameters (> 60 µm), but showed a clear divergence from the linear dependence at lower diameters. Good agreement with literature data and the large range and high measurement sensitivity point to a high potential for further investigations. 673-800 (1987). 33. J. E. Grunwald, C. E. Riva, J. Baine, and A. J. Brucker, "Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control," Invest. Ophthalmol. Vis. Sci. 33(2), 356-363 (1992). 34. J. E. Grunwald, J. DuPont, and C. E. Riva, "Retinal haemodynamics in patients with early diabetes mellitus," Br.J. Ophthalmol. 80(4), 327-331 (1996). 35. B. Pemp, E. Polska, G. Garhofer, M. Bayerle-Eder, A. Kautzky-Willer, and L. Schmetterer, "Retinal blood flow in type 1 diabetic patients with no or mild diabetic retinopathy during euglycemic clamp," Diabetes Care 33(9), 2038-2042 (2010 562-568 (1931). 39. T. W. Secomb and A. R. Pries, "Blood viscosity in microvessels: Experiment and theory," C. R. Phys. 14(6), 470-478 (2013). 40. E. Logean, L. Schmetterer, and C. E. Riva, "Velocity Profile of Red Blood Cells in Human Retinal Vessels using Confocal Scanning Laser Doppler Velocimetry," Laser Phys. 13, 45-51 (2003). 41. J. P. Garcia, Jr., P. T. Garcia, and R. B. Rosen, "Retinal blood flow in the normal human eye using the canon laser blood flowmeter," Ophthalmic Res. 34(5), 295-299 (2002)

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Section: Introductionmentioning

confidence: 99%

Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes

Doblhoff-Dier¹,

Schmetterer²,

Vilser³

et al. 2014

Biomed. Opt. Express

100

View full text Add to dashboard Cite

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“…To accomplish this, we used a delay-encoded method that we have previously demonstrated [31]. This method requires only a single OCT channel (i.e.…”

Section: Velocity Measurement By Delay Encodingmentioning

confidence: 99%

“…Alternatively, the absolute velocity vector can be determined by imaging the same location using multiple imaging beams at different angles of incidence [30][31][32][33][34][35]. This has been accomplished by utilizing polarization multiplexing [30,34], delay multiplexing [31,32], and through the use of additional OCT interferometers [33,35]. To completely determine the velocity vector with no additional information, at least three different measurements are necessary [32].…”

Section: Introductionmentioning

confidence: 99%

“…To enable pulsatile flow calculations without the need for 3-D volume acquisition we have extended the en face cross section method to the B-scan plane. To measure velocity perpendicular to the B-scan plane with a minimally-modified OCT instrument, we generate imaging beams at two different effective incidence angles using delay encoding [31]. The beams are precisely aligned so that the plane of the two angled beams is perpendicular to the B-scan direction.…”

Section: Introductionmentioning

confidence: 99%

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Orientation-independent rapid pulsatile flow measurement using dual-angle Doppler OCT

Peterson¹,

Gu²,

Jenkins³

et al. 2014

Biomed. Opt. Express

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Doppler OCT (DOCT) can provide blood flow velocity information which is valuable for investigation of microvascular structure and function. However, DOCT is only sensitive to motion parallel with the imaging beam, so that knowledge of flow direction is needed for absolute velocity determination. Here, absolute volumetric flow is calculated by integrating velocity components perpendicular to the B-scan plane. These components are acquired using two illumination beams with a predetermined angular separation, produced by a delay encoded technique. This technology enables rapid pulsatile flow measurement from single Bscans without the need for 3-D volumetric data or knowledge of blood vessel orientation. References and links1. B. Hogers, M. C. DeRuiter, A. C. Gittenberger-de Groot, and R. E. Poelmann, "Extraembryonic venous obstructions lead to cardiovascular malformations and can be embryolethal," Cardiovasc. Res. 41(1), 87-99 (1999). 2. M. L. A. Broekhuizen, B. Hogers, M. C. DeRuiter, R. E. Poelmann, A. C. Gittenberger-de Groot, and J. W.Wladimiroff, "Altered hemodynamics in chick embryos after extraembryonic venous obstruction," Ultrasound Obstet. Gynecol. 13(6), 437-445 (1999). 3. J. R. Hove, R. W. Köster, A. S. Forouhar, G. Acevedo-Bolton, S. E. Fraser, and M. Gharib, "Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis," Nature 421(6919), 172-177 (2003). 4. M. Reckova, C. Rosengarten, A. deAlmeida, C. P. Stanley, A. Wessels, R. G. Gourdie, R. P. Thompson, and D.Sedmera, "Hemodynamics is a key epigenetic factor in development of the cardiac conduction system," Circ. G. Fujimoto, and A. M. Rollins, "Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser," Opt. Express 15(10), 6251-6267 (2007

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“…As pointed out earlier, the correction of blood flow information and the extraction of quantitative blood flow parameters is very important as it may have a huge impact on retinal diagnosis. Presented solutions of this problem include the direct reconstruction of vessel orientation from 3D volumes [22,23] or the usage of multi-beam illumination to obtain the 3D velocity vector [24][25][26][27][28]. Less complex methods record two arc scans with increasing radius or use a double-circular scan pattern in order to extract the local vessel gradient from adjacent vessel cross sections [29,30].…”

Section: Introductionmentioning

confidence: 99%

Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans

Singh

Kolbitsch

Schmoll

et al. 2011

Ophthalmic Technologies XXI

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Doppler optical coherence tomography has the capability to measure blood flow quantitatively and in vivo. As only the axial component of the velocity can be assessed, the measurements have to be corrected for the angle of the vessels. We present a novel approach to extract quantitative flow data from circumpapillary scans in vivo on the human retina by registering the circular scan to a reference volume scan and extracting the angle directly from the volume. In addition, we perform phase unwrapping and interpolation of the flow under the assumption of a parabolic flow profile. We demonstrate the repeatability of the methods by applying it to different retinal vessels, achieving coefficients of variation of the average velocity of 3 to 8%. Results on the pulsatility and resistance index are also presented.

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Measurement of absolute flow velocity vector using dual-angle, delay-encoded Doppler optical coherence tomography

Cited by 62 publications

References 11 publications

Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes

Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes

Orientation-independent rapid pulsatile flow measurement using dual-angle Doppler OCT

Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans

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