Measurement of 6-MV X-ray surface dose when topical agents are applied prior to external beam irradiation

Burch, Sandra E.; Parker, Stephanie; Vann, Anne Marie; Arazie, Joan

doi:10.1016/s0360-3016(97)00095-3

Cited by 47 publications

(52 citation statements)

References 6 publications

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“…Second, the presence of metallic elements may produce secondary radiation on the skin surface, which also increases the skin surface dose. A study by Burch [7], however, that tested a variety of commonly used skin care products and deodorants (some containing zinc and aluminum), concluded that skin reactions should not increase if those agents are applied during treatment and that there is no significant bolus effect with normal use of the products using modern megavoltage radiation therapy equipment.…”

Section: Introductionmentioning

confidence: 99%

The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline

Bolderston

Lloyd

Wong

et al. 2006

Support Care Cancer

221

194

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Skin washing, including gentle washing with water alone with or without mild soap, should be permitted in patients receiving radiation therapy to prevent acute skin reaction. There is insufficient evidence to support or refute specific topical or oral agents for the prevention or management of acute skin reaction. In the expert opinion from the SCGG, the use of a plain, non-scented, lanolin-free hydrophilic cream may be helpful in preventing radiation skin reactions. In addition, a low dose (i.e., 1%) corticosteroid cream may be beneficial in the reduction of itching and irritation.

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Section: Introductionmentioning

confidence: 99%

The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline

Bolderston

Lloyd

Wong

et al. 2006

Support Care Cancer

221

194

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“…The topical corticosteroids in this review ANTICANCER RESEARCH 37: 5343-5353 (2017) 5350 vary from mild to potent and the vehicles used were mainly cream and ointment except in one study where aerosol was employed. The reason for this was to avoid the bolus effect however the increase in surface dose is not significant when a thin layer (<2 mm) of product is applied (43). The maximum application of treatment in the studies included in this review did not exceed twice daily (Table III).…”

Section: Discussionmentioning

confidence: 99%

Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Haruna

Lipsett

Marignol

2017

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(OR: 0.29; p<0.0001) and reducing the mean RD score p<0.00001 Radiation induces damage to the skin, activating inflammatory pathways and causing cytokines overproduction (1, 2). Radiation dermatitis is a common acute side-effect that occurs within hours to weeks after the start of radiotherapy (3, 4) and affects more than 87% of patients (2, 5). Radiation dermatitis can limit the therapeutic dose delivered to patients and can, sometimes, lead to a break in treatment, thus potentially compromising local control and survival outcome (1, 6). It can also have a considerable impact on patients' quality of life (7,8). Despite significant development in radiotherapy techniques, efficacious interventions in the prevention of acute skin reactions is still lacking and current evidence is unable to provide adequate guidelines for the management of this sideeffect (9, 10). Studies have examined numerous topical agents such as Aloe Vera, aqueous cream, Calendula, petrolatum and sulcrafate cream as a means to reducing the dehydrating effects of radiation dermatitis (6,11,12). However, the results in terms of managing radiation dermatitis and treatment related pain have not been clinically significant (13,14). Corticosteroids have anti-inflammatory properties and are known to down-regulate cytokine gene expression, making them ideal for managing radiation dermatitis (15-17). A systematic review by Bolderston et al. concluded that there is limited evidence to support or oppose the use of topical agents for the management of acute radiation dermatitis (18).Skin care advice given to breast cancer patients varies among institutions (19). No gold-standard for the appropriate management of this side-effect exists and in most cases the decision of care is left at the discretion of the health care professional rather than clinical evidence (20,21). Clinical advice is often given based on anecdotal evidence (22).The present systematic review and meta-analysis was conducted to assess the potential efficacy of corticosteroids in the management of RD and its impact on pain and quality of life in female breast cancer patients. However, the anticipated adverse effect associated with steroids is not evaluated and is beyond the scope of this review. We restricted our review to one site only due to radiotherapy dose variations used in different sites. Materials and MethodsSearch strategy for identification of studies. The electronic literature search was conducted up to and including March 2017. The search terms used were corticosteroid, radiation dermatitis, breast cancer, management, and prevention. The reference lists of potentially eligible studies were subsequently hand searched to identify 5343

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“…We saw no possible negative effect on the acute skin reactions or on impairment. The recommendation to clean the skin in radiation fields with water is based on the experiences of other authors [4,14].…”

Section: Discussionmentioning

confidence: 99%

“…According to Burch et al [4] there is no unwelcome bolus effect of topical agents in the radiation field to be feared. Application of 10% sucralfate in sorbolene creme or application of topical solution containing ascorbic acid had no advantageous effect on acute skin reaction or subjective impairment [6,10,12].…”

Section: Discussionmentioning

confidence: 99%

Intraindividual Comparison of Two Different Skin Care Conceptions in Patients Undergoing Radiotherapy of the Head-and-Neck Region Creme or Powder?

Schreck

Paulsen²,

Bamberg³

et al. 2002

Strahlenther Onkol

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Measurement of 6-MV X-ray surface dose when topical agents are applied prior to external beam irradiation

Cited by 47 publications

References 6 publications

The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline

The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline

Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Intraindividual Comparison of Two Different Skin Care Conceptions in Patients Undergoing Radiotherapy of the Head-and-Neck Region Creme or Powder?

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