Measurement of 239 Pu in keratinous materials: A potential non-invasive bioassay for monitoring human exposure

Brown, John W. N.; Brockman, John; Robertson, John

doi:10.1016/j.apradiso.2017.06.047

Cited by 3 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides environmental and nuclear samples, noninvasive biological samples (e.g., hair, urine) for TRU radionuclides could provide the source information of the exposure sites and the circumstance. 7 The major challenge for such work is that the sample size is often very small, and a highly sensitive method to measure the attogram−femtogram level radionuclides is therefore needed. 6,8−10 In order to achieve detection at such levels, this usually requires a complete separation of TRUs from the matrix and potential interferences in combination with the measurement techniques with high sensitivity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…For instance, the 240 Pu/ 239 Pu and 237 Np/ 239 Pu atomic ratios as excellent indicators are an important signature reflecting the type of nuclear reactor design, and the parent/daughter ratios (e.g., 241 Pu/ 241 Am, 244 Cm/ 240 Pu) are unique clock indicators for estimation of the production date of the nuclear material. Besides environmental and nuclear samples, noninvasive biological samples (e.g., hair, urine) for TRU radionuclides could provide the source information of the exposure sites and the circumstance . The major challenge for such work is that the sample size is often very small, and a highly sensitive method to measure the attogram–femtogram level radionuclides is therefore needed. ,− In order to achieve detection at such levels, this usually requires a complete separation of TRUs from the matrix and potential interferences in combination with the measurement techniques with high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous Determination of Transuranium Radionuclides for Nuclear Forensics by Compact Accelerator Mass Spectrometry

et al. 2023

View full text Add to dashboard Cite

Accelerator mass spectrometry (AMS) is one of the most sensitive techniques used to measure the long-lived actinides. This is particularly of interest for determination of ultra-trace transuranium nuclides and their isotopic fingerprints for nuclear forensics. In this work, a new method was developed for simultaneous determination of transuranium nuclides (Np, Pu, Am, and Cm isotopes) by using 300 kV AMS after a sequential chemical separation of each group of actinides. 242Pu and 243Am were utilized as tracers for Np/Pu and Am/Cm yield monitoring. The results show that the chemical behaviors of Np and Pu on the TK200 column and those of Am and Cm on the DGA column were very consistent in 8–9 mol/L of HNO3 and 0.015–0.03 mol/L of NaNO2 media during the radiochemical separation. The AMS detection efficiencies for transuranium nuclides were also evaluated. The detection limits for all radionuclides are below femtogram level and even in attogram level for Pu and Cm isotopes. The established method has been successfully applied to accurately measure various transuranium nuclides in a single actinide radionuclide solution, demonstrating its feasibility for nuclear forensic investigation.

show abstract

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Transuranium Radionuclides for Nuclear Forensics by Compact Accelerator Mass Spectrometry

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Therefore, nails contain small quantities of trace elements such as S (its main component), Ca, Cu, Fe, Zn, and others [8; 9; 10]. Like blood and urine, nail samples can be used as biomarkers of several dysfunction : while Fe, Se, and Zn have been correlated with colorectal cancer risk [11], the evaluation of metals (Pb, Cd, Hg) in nails have also been performed to investigate toxicity effects in the organism [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

X- ray experimental set-up for in-vitro nail test

et al. 2023

View full text Add to dashboard Cite

In this investigation, the elements Ca and S were evaluated in a single nail clipping using compact and portable X-ray spectrometer model X-123 SDD with Ag target. Experimental conditions for current, voltage and excitation time were investigated. These analyses can be useful for a variety of applications, including nutritional and medical diagnosis, such as, the evaluation of bone dysfunctions by measurement of Ca (bone decalcification) and S for nutrition evaluations (collagen production). This analysis offers some benefits comparatively to blood and serum analyses, such as, non-invasive collection, fast analyses (minutes) and low cost. In addition, nail clippings are simple to obtain, easy to store, and easy to transport. This pilot study show a positive expectation for clinical application using in-vitro nail test.

show abstract

A multi-collector ICP-MS method for quantification of plutonium, uranium, and americium in hair and nails of occupationally or medically exposed individuals

Arbova,

Tolmachev,

Brockman

2024

Talanta

View full text Add to dashboard Cite

Measurement of 239 Pu in keratinous materials: A potential non-invasive bioassay for monitoring human exposure

Cited by 3 publications

References 14 publications

Simultaneous Determination of Transuranium Radionuclides for Nuclear Forensics by Compact Accelerator Mass Spectrometry

Simultaneous Determination of Transuranium Radionuclides for Nuclear Forensics by Compact Accelerator Mass Spectrometry

X- ray experimental set-up for in-vitro nail test

A multi-collector ICP-MS method for quantification of plutonium, uranium, and americium in hair and nails of occupationally or medically exposed individuals

Contact Info

Product

Resources

About