Precise investigation of aero-thermodynamic and chemical processes relating to environmental precursor pollutants in an aircraft turbine is challenging because of the complexity of transformation processes at high temperature and high pressure. We present here, for the first time, new insights into the study of aero-thermodynamic processes, formation of nitrate and sulfate aerosol precursors, and investigate the influence of chemical processes on aero-thermodynamics. We also shed light on the effect of three-dimensional blade profile, radial spacing, and rotor speed on the performance of a high-pressure turbine. We highlight that flow vortex and the variation of chemical formation which appear in both rear stator blades and rear rotor blades. We found that the chemical processes were affected by the evolution of temperature (maximum of 16.9%) and flow velocity (maximum of 38.8%). Contrary to the conservative one-dimensional and two-dimensional modeling, which provide only the flow trends and flow evolution at cylindrical surface, respectively, our three-dimensional modeling approach offers the possibility of combining information on radial spacing and rotor-speed effect by providing three-dimensional images of spatial-geometry effect on aero-thermodynamic and chemical processes. Quantitatively, the magnitude of change in aero-thermodynamics and nitrogen oxidation may be expected to be up to 17% and 48%, respectively, over a stage of the high-pressure turbine.