Measurement and modeling solubility of bioactive coumarin and its derivatives in supercritical carbon dioxide

Yoo, Ki‐Pung; Shin, Hun Yong; Noh, Min Jeong; You, Seong Sik

doi:10.1007/bf02707049

Cited by 12 publications

(9 citation statements)

References 5 publications

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“…Critical temperature (T c = 794.77 K), critical pressure (P c = 4.347 MPa), and acentric factor (w = 0.3945) of coumarin used in the PR-EoS were obtained using the Constantinou and Gani method (Poling et al, 2000). Similar values were found by Yoo et al (1997) using the Lyderson-Forman-Thodos method. The values of same properties for CO 2 were obtained from Poling et al (2000).…”

Section: Thermodynamic Modelingsupporting

confidence: 86%

“…In addition, it is not possible to visualize both a homogeneous phase and phase transition through the extractive method. Yoo et al (1997) determined solubility values of coumarin in supercritical CO 2 using a microscale apparatus through the analytical method. The authors observed lower values than those found in the present work.…”

Section: Resultsmentioning

confidence: 99%

“…Coumarin solubility investigations by analytical or semi-continuous flow methods are available in the literature (Rodrigues et al, 2008;Yoo et al, 1997). In these methods, the composition varies throughout the experiment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phase Behavior Data and Thermodynamic Modeling of the Binary System {Co2 + Coumarin} at High Pressures

Lima

Jaski

Cabral

et al. 2019

Braz. J. Chem. Eng.

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In this work, vapor-liquid (VLE) equilibrium for the binary system carbon dioxide (1) + coumarin (2) at high pressures was measured by a static synthetic method using a variable-volume view cell. Experimental data were obtained in the temperature range of 318-338 K and pressures up to 20 MPa. Coumarin molar fraction ranged from 3.0x10-3 to 6.0x10-3. Coumarin melting point reduction at high pressures was observed. The experimental results were modeled using the Peng-Robinson (PR) equation of state with van der Waals quadratic mixing rules (vdW-QMRs), providing a good representation of the experimental phase equilibrium data. Critical properties and the acentric factor were estimated using the Constantinou and Gani method, which showed to be satisfactory on the quality of data correlation. Results indicate coumarin solubility increases with increasing phase transition pressure at a given temperature.

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Section: Thermodynamic Modelingsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Phase Behavior Data and Thermodynamic Modeling of the Binary System {Co2 + Coumarin} at High Pressures

Lima

Jaski

Cabral

et al. 2019

Braz. J. Chem. Eng.

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“…Food processing industry is a major user of the supercritical fluid carbon dioxide extraction process, and the applications include extraction and fractionation of fats, oils, essences, pigments, and functional or bioactive compounds (Reverchon 1997). Majority of the published work on coumarin extraction using supercritical fluid carbon dioxide has focused on solubility of coumarin and its derivatives in supercritical fluid carbon dioxide (Ehlers et al 1996;Yoo et al 1997;Choi et al 1998;Rodrigues et al 2008). However, the information on coumarin extraction from C. reflexa using supercritical fluid carbon dioxide is still lacking in literatures.…”

Section: Introductionmentioning

confidence: 99%

Coumarin Extraction from Cuscuta reflexa using Supercritical Fluid Carbon Dioxide and Development of an Artificial Neural Network Model to Predict the Coumarin Yield

Mitra

Barman

Chang

2009

Food Bioprocess Technol

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Coumarin found in Cuscuta reflexa (a medicinal herb) is a phytochemical that possesses blood-thinning, anti-fungicidal and anti-tumor activities, and increases the blood flow in the veins and decreases capillary permeability. Supercritical fluid carbon dioxide extraction is an effective method for extraction and separation of organic compounds. Coumarin was extracted using supercritical fluid carbon dioxide associated with a small amount of a co-solvent methanol to increase the selectivity of carbon dioxide and identified by high-performance liquid chromatography comparing with authentic coumarin standard. Determination of proper extracting temperature, time, and pressure is essential for the maximum extract of coumarin yield. Coumarin was extracted under different extraction conditions of temperature (35-75°C), time (30-150 min), and pressure (15,160-34,450 kPa). Central composite rotate design was used to plan the experimental extraction conditions. The highest yield of coumarin was 90.13±0.11 (µg/g), while extraction was done at 55°C for 150 min under 24,805 kPa. A feedforward multilayer backpropagation artificial neural network (ANN) model was developed for the prediction of coumarin yield (µg/g), where input variables were temperature, time, and pressure. Several configurations were evaluated while developing the optimal ANN model. The optimal ANN model consisted of one hidden layer and five neurons. This model was able to predict coumarin yield quantitatively. Prediction of coumarin yields using the ANN model was proven to be a simple, convenient, and accurate method.

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“…Beside this, the production of plant extracts is currently limited by safety and regulatory constraints to the concentration of toxic residues of conventional organic solvents [14]. Supercritical fluid extraction has been widely employed as an alternative to organic solvent for the extraction of a variety of compounds from different matrices [15][16][17][18][19][20][21]. Carbon dioxide (CO 2 ) is probably the most widely used supercritical fluid because of its critical temperature (31.1 o C), which makes it an ideal solvent for extracting thermally labile materials.…”

Section: Introductionmentioning

confidence: 99%

Solubility of red pepper (Capsicum annum) oil in near- and supercritical carbon dioxide and quantification of capsaicin

Kwon

Uddin

Jung

et al. 2011

Korean J. Chem. Eng.

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Red pepper oil was extracted using near-and supercritical carbon dioxide. Extraction was carried out at pressures ranging from 10 to 35 MPa and temperatures from 30 to 60 o C, with a CO 2 flow rate of 24.01 g/min using a semi-continuous high-pressure extraction apparatus. The duration for extraction was 2 h. The highest oil yield was found at high pressure and temperature. The highest solubility of oil (1.18 mg/g of CO 2 ) was found at 35 MPa and 60 o C. The solubility data of red pepper oil in near-and supercritical CO 2 were fitted in Chrastil model. The fatty acid composition of red pepper oil was analyzed by gas chromatography (GC). Linoleic acid was found to be the major fatty acid in the oil. Capsaicin was quantified in different extracts by high performance liquid chromatography (HPLC). The highest capsaicin yield was found at 35 MPa and 60 o C.

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Measurement and modeling solubility of bioactive coumarin and its derivatives in supercritical carbon dioxide

Cited by 12 publications

References 5 publications

Phase Behavior Data and Thermodynamic Modeling of the Binary System {Co2 + Coumarin} at High Pressures

Phase Behavior Data and Thermodynamic Modeling of the Binary System {Co2 + Coumarin} at High Pressures

Coumarin Extraction from Cuscuta reflexa using Supercritical Fluid Carbon Dioxide and Development of an Artificial Neural Network Model to Predict the Coumarin Yield

Solubility of red pepper (Capsicum annum) oil in near- and supercritical carbon dioxide and quantification of capsaicin

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