Measurement and Modeling of Solid–Liquid Equilibria of l-Glutamic Acid in Pure Solvents and Aqueous Binary Mixtures

Abstract

The experimental solubility data of L-glutamic acid in pure water, formic acid, methanol, 1-propanol, 2-propanol, acetonitrile, and binary mixtures (formic acid + water, methanol + water, 2-propanol + water, acetonitrile + water) with different compositions were carried out at temperatures ranging from (283.15 to 328.15) K by the static analytic method. The solubility measurements showed that formic acid and its aqueous mixtures recorded a higher solubility than methanol + water, 2-propanol + water, and acetonitrile + water for the same composition at each temperature. Moreover, except formic acid the addition of methanol, 2-propanol, and acetonitrile to its aqueous mixtures resulted in the decrease in solubility of L-glutamic acid. The experimental data was fitted using different thermodynamic models such as the Buchowski−Ksiazczak equation, the Van't Hoff equation, the modified Apelblat equation, and the NRTL model, and the optimum values of the regressed parameters were obtained. The modified Apelblat equation, Buchowski−Ksiazczak equation, and NRTL activity coefficient model were fitted to the pure solvents solubility data, while the modified Apelblat, modified Apelblat−Jouyban−Acree, and NRTL models were used for the binary solvent systems. The results demonstrated formic acid as a cosolvent in the dissolution of L-glutamic acid in formic acid + water binary mixtures, while others exhibited an antisolvent effect on the solubilization of L-glutamic acid in their respective aqueous mixtures.

Shaping particle size distribution of a metastable polymorph in additive-assisted reactive crystallization by the Taguchi method

“…Although the solubility of L-GLU in water or water/organic solvent mixtures has been determined, [66][67][68] it is much less common to prepare L-GLU polymorphs by antisolvent crystallization in the literature. 45,69 As ethanol was used as an antisolvent, the mass fraction of α-GLU increased with the increasing ratio of antisolvent-to-solvent.…”

Effect of Ammonium Sulfate on the Solubility of α-Form and β-Form l-Glutamic Acid in Water and Actual Fermentation Mother Liquor from 278.15 to 333.15 K

“…The solubility of α-form and β-form l -glutamic acid was first measured in pure water using the static analytical method and compared with the data available in the literature , in order to validate the experimental protocol. Then, the solubility of both polymorphs was measured in aqueous solutions with defined molarity of (NH 4 ) 2 SO 4 (0, 0.25, 0.50, 0.75, 1.00, 1.25, and 1.50 mol/kg) or in the GAFML in the absence and presence of (NH 4 ) 2 SO 4 at 0.75 mol/kg.…”

Measurement and Correlation of the Solubility of 4,4′-Oxydianiline in Four Binary Solvent Mixtures from T = 293.15 to 333.15 K

“…Solubility Measurement. The solubility of ODA in ethanol + DMSO, ethanol + DMAC, ethanol + DMF, and ethanol + EM solvent mixtures was measured through a gravimetric method 6 in the temperature range of 293.15 to 333.15 K, while the mass fraction of ethanol in the solvent mixtures varied from 0 to 1, with an interval of 0.1. The experimental procedures are described as follows: first, 10 mL of prepared binary solvent mixtures was added to a 20 mL glass vial with an excess amount of ODA solid, and the vial was sealed and placed in a large jacketed vessel.…”