Measurement and modeling of optical properties of heated adipose tissue in the terahertz range

Yanina, Irina Yu.; Nikolaev, Viktor V.; Захарова, О. А.; Borisov, Alexey V.; Dvoretski, K. N.; Berezin, K. V.; Kochubey, Vyacheslav I.; Kistenev, Yuri; Tuchin, Valery V.

doi:10.1117/12.2555656

Cited by 3 publications

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“… Spatial configurations of different triglycerides of fatty acids: linolic ( a ), oleic ( b ), α-linolenic( c ), stearic ( d ) and palmitic ( e ) acids [ 87 ], where the white ball is a hydrogen atom; the red ball is an oxygen atom; and the gray ball is a carbon atom. …”

Section: Figurementioning

confidence: 99%

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

et al. 2022

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In this paper, the measurement and modeling of optical properties in the terahertz (THz) range of adipose tissue and its components with temperature changes were performed. Spectral measurements were made in the frequency range 0.25–1 THz. The structural models of main triglycerides of fatty acids are constructed using the B3LYP/6-31G(d) method and the Gaussian03, Revision B.03 program. The optical density (OD) of adipose tissue samples decreases as temperature increases, which can be associated mostly with the dehydration of the sample. Some inclusion of THz wave scattering suppression into the OD decrease can also be expected due to refractive index matching provided by free fatty acids released from adipocytes at thermally induced cell lipolysis. It was shown that the difference between the THz absorption spectra of water and fat makes it possible to estimate the water content in adipose tissue. The proposed model was verified on the basis of molecular modeling and a comparison with experimental data for terahertz spectra of adipose tissue during its heating. Knowing the exact percentage of free and bound water in adipose tissue can help diagnose and monitor diseases, such as diabetes, obesity, and cancer.

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Section: Figurementioning

confidence: 99%

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

et al. 2022

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“…For example, the bulk water content of melanoma is in the region of 80-85%, compared to 70-72% in normal skin [10]. Temperature dependent variation of THz dielectric parameters in biological tissues has been reported by several authors [11][12][13]. The reported data are typically limited to frequencies of less than 1.2 to 1.5 THz.…”

Section: Overviewmentioning

confidence: 99%

Using Attenuated Total Reflection (ATR) Apparatus to Investigate the Temperature Dependent Dielectric Properties of Water, Ice, and Tissue-Representative Fats

Vilagosh¹,

Lajevardipour²,

Appadoo³

et al. 2021

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A novel method of investigating the temperature dependent variation of aspects of the complex refractive index n* in samples in the THz range using continuous, non-polarised, synchrotron radiation is presented. The method relies on the use of ATR apparatus, and retains the advantage of minimal sample preparation, which is a feature of ATR techniques. The method demonstrates the viability of rapidly monitoring temperature reflectance whilst continuously heating or cooling samples by using a temperature variable Thermal Sample Stage. The method remains useful when the refractive index of the sample precludes attenuated total reflection study. This is demonstrated with the water reflectance experiments. The temperature dependent ATR reflectance of tissue-representative fats (lard and Lurpak® butter) was investigated with the novel approach. Both are within the ATR range of the diamond crystal in a “true” ATR mode. Lard showed no clear temperature variation between -15 0C and 24 0C at 0.7 to 1.15 THz or 1.70 to 2.25 THz. Lard can be regarded as having invariable, constant, dielectric properties within mixtures when biological substances are being assessed for temperature dependent dielectric variation within the stated THz ranges. Lurpak® butter (water content 14.7%) displayed temperature dependent reflectance features with a steady decline in reflectivity with increasing temperature. This is in line with the temperature-dependent behaviour of liquid water. There is no rapid change in reflectance, even at -20 0C, suggesting that emulsified water retains liquid-water-like THz properties at freezing temperatures.

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Using Attenuated Total Reflection (ATR) Apparatus to Investigate the Temperature Dependent Dielectric Properties of Water, Ice, and Tissue-Representative Fats

et al. 2021

View full text Add to dashboard Cite

A novel method of investigating the temperature dependent variation of aspects of the complex refractive index n* in samples in the THz range using continuous, non-polarised, synchrotron radiation is presented. The method relies on the use of ATR apparatus, and retains the advantage of minimal sample preparation, which is a feature of ATR techniques. The method demonstrates a “proof of concept” of monitoring temperature reflectance whilst continuously heating or cooling samples by using a temperature variable Thermal Sample Stage. The method remains useful when the refractive index of the sample precludes attenuated total reflection study. This is demonstrated with the water reflectance experiments. The temperature dependent ATR reflectance of tissue-representative fats (lard and Lurpak® butter) was investigated with the novel approach. Both are within the ATR range of the diamond crystal in a “true” ATR mode. Lard showed no clear temperature variation between −15 °C and 24 °C at 0.7 to 1.15 THz or 1.70 to 2.25 THz. Lard can be regarded as having invariable, constant, dielectric properties within mixtures when biological substances are being assessed for temperature dependent dielectric variation within the stated THz ranges. Lurpak® butter (water content 14.7%) displayed temperature dependent reflected signal intensity features with a steady decline in reflectivity with increasing temperature. This is in line with the temperature-dependent behaviour of liquid water. There is no rapid change in reflected signal intensity even at −20 °C, suggesting that emulsified water retains liquid-water-like THz properties at freezing temperatures.

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Measurement and modeling of optical properties of heated adipose tissue in the terahertz range

Cited by 3 publications

References 0 publications

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

Using Attenuated Total Reflection (ATR) Apparatus to Investigate the Temperature Dependent Dielectric Properties of Water, Ice, and Tissue-Representative Fats

Using Attenuated Total Reflection (ATR) Apparatus to Investigate the Temperature Dependent Dielectric Properties of Water, Ice, and Tissue-Representative Fats

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