Measurement and evaluation of biomechanical properties of cornea “in vivo”

Hučko, Branislav; Rybář, Jan; Ďuriš, Stanislav; Grosinger, Patrik; Pluháček, František; Plesníková, Paulína; Furdová, Alena; Sekac, Juraj; Veselý, Pavol

doi:10.1016/j.measen.2021.100281

Cited by 1 publication

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“…IOP is a measurement including the magnitude of the force exerted by the aqueous humor on the internal surface area of the anterior eye [ 56 ]. IOP is considered as the key parameter to determine the health of the eye since it could be increased due to anatomical problems, genetic factors, inflammation of the eye, or as a side-effect from medication [ 57 ] but is also a major risk factor for glaucoma [ 58 ]. The normal intraocular pressure is varies between 12 and 22 mm Hg, with cyclic fluctuations of 2–3 mm Hg throughout the day with the lowest being at night due to circadian regulation of aqueous humor secretion [ 59 ] and peaking in the early morning [ 60 ].…”

Section: Factors Leading To Alterations Of Biomechanical Propertiesmentioning

confidence: 99%

Corneal biomechanics and diagnostics: a review

Komninou,

Seiler,

Enzmann

2024

Int Ophthalmol

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Purpose Corneal biomechanics is an emerging field and the interest into physical and biological interrelations in the anterior part of the eye has significantly increased during the past years. There are many factors that determine corneal biomechanics such as hormonal fluctuations, hydration and environmental factors. Other factors that can affect the corneas are the age, the intraocular pressure and the central corneal thickness. The purpose of this review is to evaluate the factors affecting corneal biomechanics and the recent advancements in non-destructive, in vivo measurement techniques for early detection and improved management of corneal diseases. Methods Until recently, corneal biomechanics could not be directly assessed in humans and were instead inferred from geometrical cornea analysis and ex vivo biomechanical testing. The current research has made strides in studying and creating non-destructive and contactless techniques to measure the biomechanical properties of the cornea in vivo. Results Research has indicated that altered corneal biomechanics contribute to diseases such as keratoconus and glaucoma. The identification of pathological corneas through the new measurement techniques is imperative for preventing postoperative complications. Conclusions Identification of pathological corneas is crucial for the prevention of postoperative complications. Therefore, a better understanding of corneal biomechanics will lead to earlier diagnosis of ectatic disorders, improve current refractive surgeries and allow for a better postoperative treatment.

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