Measurement and Control of Ultra-Low Liquid Flowrates for Drug Delivery Application

Damiani, Christian; Klein, Stephan; Wuttig, Daniel; Nestler, B.

doi:10.1007/978-3-540-69367-3_57

Cited by 1 publication

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“…They are also utilized to monitor the outcome of abdominal aortic aneurysms surgery [11], in the long term monitoring of prosthetic devices, in respiratory monitoring to measure gas flows in spirometric devices [12], to diagnose salivary gland [13] and stomach diseases [14], and in microfabricated drug delivery devices [15]. In this review we do not exhaustively present each application of micromachined sensors in the biomedical field, rather we focus our attention on some applications of micro flow sensors in the monitoring of physiological parameters or used as a feedback in delivery microsystems [16]. This paper is divided into subsections where a concise description of the measurement principle of micromachined flow sensors is presented along with the main biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Micromachined Flow Sensors in Biomedical Applications

Silvestri

Schena

2012

Micromachines

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Application fields of micromachined devices are growing very rapidly due to the continuous improvement of three dimensional technologies of micro-fabrication. In particular, applications of micromachined sensors to monitor gas and liquid flows hold immense potential because of their valuable characteristics (e.g., low energy consumption, relatively good accuracy, the ability to measure very small flow, and small size). Moreover, the feedback provided by integrating microflow sensors to micro mass flow controllers is essential to deliver accurately set target small flows. This paper is a review of some application areas in the biomedical field of micromachined flow sensors, such as blood flow, respiratory monitoring, and drug delivery among others. Particular attention is dedicated to the description of the measurement principles utilized in early and current research. Finally, some observations about characteristics and issues of these devices are also reported.

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