Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation

Leeuwen, Caspar M. van; Oei, Arlene L.; Cate, Rosemarie ten; Franken, Nicolaas A.P.; Bel, Arjan; Stalpers, Lukas J.A.; Crezee, J.; Kok, H. Petra

doi:10.1080/02656736.2017.1320812

Cited by 36 publications

(74 citation statements)

References 49 publications

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“…HT alone had a significant sensitizing effect on the linear parameter, α, in both SiHa and HeLa cells, which has also been shown previously in other cell lines [29,31,33]. In SiHa cells, both PARP1- i and DNA-PKcs- i appeared to be sensitizing agents for low dosages of RT, since the value of the linear parameter was significantly increased (Figure 2).…”

Section: Discussionsupporting

confidence: 84%

“…The α determines the initial slope of cell survival curves and the effectiveness at low doses of ionizing radiation, while β represents the increasing contribution from cumulative damage, presumably due to the interaction of two or more lesions induced by separate energy depositions [32]. Therefore, by using these parameters, information is obtained on acute and late responses and even additional doses after ionizing radiation-induced breaks can be calculated using the LQ model [29,33]. …”

Section: Introductionmentioning

confidence: 99%

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Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents

IJff

Oorschot

Oei

et al. 2018

IJMS

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Hyperthermia (HT) and molecular targeting agents can be used to enhance the effect of radiotherapy (RT). The purpose of this paper is to evaluate radiation sensitization by HT and different molecular targeting agents (Poly [ADP-ribose] polymerase 1 inhibitor, PARP1-i; DNA-dependent protein kinase catalytic subunit inhibitor, DNA-PKcs-i and Heat Shock Protein 90 inhibitor, HSP90-i) in cervical cancer cell lines. Survival curves of SiHa and HeLa cells, concerning the combined effects of radiation with hyperthermia and PARP1-i, DNA-PKcs-i or HSP90-i, were analyzed using the linear-quadratic model: S(D)/S(0) = exp − (αD + βD2). The values of the linear-quadratic (LQ) parameters α and β, determine the effectiveness at low and high doses, respectively. The effects of these sensitizing agents on the LQ parameters are compared to evaluate dose-dependent differences in radio enhancement. Combination of radiation with hyperthermia, PARP1-i and DNA-PKcs-i significantly increased the value of the linear parameter α. Both α and β were significantly increased for HSP90-i combined with hyperthermia in HeLa cells, though not in SiHa cells. The Homologous Recombination pathway is inhibited by hyperthermia. When hyperthermia is combined with DNA-PKcs-i and PARP1-i, the Non-Homologous End Joining or Alternative Non-Homologous End Joining pathway is also inhibited, leading to a more potent radio enhancement. The observed increments of the α value imply that significant radio enhancement is obtained at clinically-used radiotherapy doses. Furthermore, the sensitizing effects of hyperthermia can be even further enhanced when combined with other molecular targeting agents.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents

IJff

Oorschot

Oei

et al. 2018

IJMS

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“…Note that these expressions are symmetric in t int ¼ 0 h, that is, the radiosensitization is the same regardless of whether hyperthermia is given before or after radiotherapy. This was based on the symmetry observed in in vitro survival of cervical cancer cells for radiotherapy before and after hyperthermia [18]. The direct cytotoxic effect of hyperthermia in tumor tissue was accounted for by a term based on the Arrhenius relationship [18].…”

Section: Biological Modelingmentioning

confidence: 99%

“…The effect of hyperthermia is known to depend on the temperature distribution and the time interval between radiotherapy and hyperthermia [16][17][18]. Clinically applied time intervals between radiotherapy and hyperthermia in the treatment of cervical cancer vary substantially: a recent retrospective study showed that the majority of time intervals at the AMC were between 1-1.5 h [17], while in the Dutch Deep Hyperthermia trial time intervals ranged from 30 min to 4 h [3].…”

Section: Introductionmentioning

confidence: 99%

“…Derivation of an optimal time interval requires a planning study that models radiosensitization, taking into account the heterogeneous radiation dose and temperature distributions. Radiosensitization can be modelled using an extended version of the LQ-model with temperature-dependent radiosensitivity parameters (a and b) [18,[21][22][23]. This can be used to calculate the equivalent radiation dose (EQD RT ), the dose needed in a radiotherapy-only treatment to obtain the same biological effect as the combined radiotherapy and hyperthermia treatment [24].…”

Section: Introductionmentioning

confidence: 99%

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The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose

Leeuwen

Crezee

Oei

et al. 2018

International Journal of Hyperthermia

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Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities

Ahire,

Ahmadi Bidakhvidi,

Boterberg

et al. 2023

Radiobiology Textbook

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In this chapter, we address the role of radiation as treatment modality in the context of oncological treatments given to patients. Physical aspects of the use of ionizing radiation (IR)—by either photons, neutrons, or charged (high linear energy transfer) particles—and their clinical application are summarized. Information is also provided regarding the radiobiological rationale of the use of conventional fractionation as well as alternative fractionation schedules using deviating total dose, fraction size, number of fractions, and the overall treatment time. Pro- and contra arguments of hypofractionation are discussed. In particular, the biological rationale and clinical application of Stereotactic Body Radiation Therapy (SBRT) are described. Furthermore, background information is given about FLASH radiotherapy (RT), which is an emerging new radiation method using ultra-high dose rate allowing the healthy, normal tissues and organs to be spared while maintaining the antitumor effect. Spatial fractionation of radiation in tumor therapy, another method that reduces damage to normal tissue is presented. Normal tissue doses could also be minimized by interstitial or intraluminal irradiation, i.e., brachytherapy, and herein an overview is given on the principles of brachytherapy and its clinical application. Furthermore, details are provided regarding the principles, clinical application, and limitations of boron neutron capture therapy (BNCT). Another important key issue in cancer therapy is the combination of RT with other treatment modalities, e.g., chemotherapy, targeted therapy, immunotherapy, hyperthermia, and hormonal therapy. Combination treatments are aimed to selectively enhance the effect of radiation in cancer cells or to trigger the immune system but also to minimize adverse effects on normal cells. The biological rationale of all these combination treatments as well as their application in clinical settings are outlined. To selectively reach high concentrations of radionuclides in tumor tissue, radioembolization is a highly interesting approach. Also, radioligand therapy which enables specific targeting of cancer cells, while causing minimal harm surrounding healthy tissues is presented. A brief overview is provided on how nanotechnology could contribute to the diagnosis and treatment of cancer. Last but not least, risk factors involved in acquiring secondary tumors after RT are discussed.

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Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation

Abstract: This study presents a model that describes the cell survival as a function of radiation dose, temperature and time interval, which is essential for biological modelling of thermoradiotherapy treatments.

Cited by 36 publications

References 49 publications

Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents

Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents

The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose

Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities

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