Measurable serum markers of oxidative stress response in women with endometriosis

Serum and peritoneal fluid levels of ischemia modified albumin in moderate/severe endometriosis

“…19 Among these studies only one, have evaluated the levels of serum IMA in endometriosis as a marker of protein oxidation. 20 In that study, as in ours, no significant difference was found in serum IMA levels when endometriosis cases were compared with healthy controls. 20 However, that study did not analyse peritoneal fluid IMA levels.…”

“…20 In that study, as in ours, no significant difference was found in serum IMA levels when endometriosis cases were compared with healthy controls. 20 However, that study did not analyse peritoneal fluid IMA levels. In endometriosis, peritoneal fluid contains high concentrations of pro-inflammatory and chemotactic cytokines that activates phagocytic cells and apoptotic endometrial tissue accumulated in endometriotic implants, which are the basic producers of ROS.…”

“…The previous data documenting serum IMA levels in endometriosis cases used an ELISA method by a commercial kit. 20 Therefore, the authors determined serum IMA levels in U/mL which makes it impossible to compare their data with our results (ABSU). The test in the study of Lambrinoudaki is an indirect test for IMA using an antibody where the method in present study is different from the commercial kits, which is a direct measurement of IMA.…”

“…The test in the study of Lambrinoudaki is an indirect test for IMA using an antibody where the method in present study is different from the commercial kits, which is a direct measurement of IMA. 20 Therefore, more valid data is accounted by our study.…”

Effect of Goserlin Acetate and Oxidative Stress in Iraqi Women with Recurrenceof Endometriosis

“…The antioxidant activity of estrogens is associated with the phenol structure of estradiol and its metabolites [7].Oxidative stress (OS) substances may have a contributive role in the pathogenesis of endometriosis through the activation of macrophages. These activated macrophages can aggravate oxidative stress conditions by the production of lipid peroxides and other by-products from reaction between apolipoproteins and peroxides [8].Vivian et al showed thatproduction of reactive oxygen species (ROS) by peritoneal fluid mononuclear cellswas increased in endometriosis [9].Oxidative damage occurs as a result of deficient antioxidant defensive mechanisms due to the effect of endogenous and exogenous factors. The aim of this study was to investigate the effect of goserlin acetate treatment on the hormonal changes, antioxidant status and oxidative stress (MDA) in goserelin acetatetreated patients with endometriosis and attempted to find the correlation between all these parameters with lipid peroxidation, given by MDA level's determination.…”