Measles seroprevalence, outbreaks, and vaccine coverage in Rwanda

Seruyange, Eric; Gahutu, Jean Bosco; Muvunyi, Claude Mambo; Uwimana, Zena G.; Gatera, Maurice; Twagirumugabe, Théogène; Katare, Swaibu; Karenzi, Ben; Bergström, Tomas

doi:10.1080/23744235.2016.1201720

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Swedish donors samples were used as expected negative control group to the Zika virus seroprevalence among Rwandan donors, but for comparison of the immunity to Rubella virus within Rwandan and Swedish donors. Part of this material was previously analyzed for a seroprevalence study of IgG to measles virus in Rwanda . Samples were collected from all four provinces of Rwanda and from the city of Kigali.…”

Section: Methodsmentioning

confidence: 99%

Seroprevalence of Zika virus and Rubella virus IgG among blood donors in Rwanda and in Sweden

Seruyange

Gahutu

Muvunyi

et al. 2018

Journal of Medical Virology

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Seroprevalence studies provide information on the susceptibility to infection of certain populations, including women of childbearing age. Such data from Central Africa are scarce regarding two viruses that cause congenital infections: Zika virus (ZIKV), an emerging mosquito-borne infection, and Rubella virus (RuV), a vaccine-preventable infection. We report on the seroprevalence of both ZIKV and RuV from Rwanda, a country without any known cases of ZIKV, but bordering Uganda where this virus was isolated in 1947. Anti-ZIKV-specific and anti-RuV-specific immunoglobulin G (IgG) antibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in serum samples from 874 Rwandan and 215 Swedish blood donors. Samples positive for IgG antibodies against ZIKV were examined for viral RNA using real-time reverse transcription polymerase chain reaction (RT-qPCR). The seroprevalence of ZIKV IgG in Rwanda was 1.4% (12/874), of which the predominance of positive findings came from the Southeastern region. All anti-ZIKV IgG-positive samples were PCR-negative. Among 297 female blood donors of childbearing age, 295 (99.3%) were seronegative and thus susceptible to ZIKV. All Swedish blood donors were IgG-negative to ZIKV. In contrast, blood donors from both countries showed high seroprevalence of IgG to RuV: 91.2% for Rwandan and 92.1% for Swedish donors. Only 10.5% (31/294) of female donors of childbearing age from Rwanda were seronegative for RuV. In Rwanda, seroprevalence for ZIKV IgG antibodies was low, but high for RuV. Hence, women of childbearing age were susceptible to ZIKV. These data may be of value for decision-making regarding prophylactic measures.

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Section: Methodsmentioning

confidence: 99%

Seroprevalence of Zika virus and Rubella virus IgG among blood donors in Rwanda and in Sweden

Seruyange

Gahutu

Muvunyi

et al. 2018

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“… 2 As a result, national immunization coverage rates are high and new vaccines are introduced swiftly. 3 , 4 Nevertheless, some communities still face local disease outbreaks due to underimmunization. A major driver of underimmunization is vaccine hesitancy, 5 which is defined by the World Health Organization (WHO) as “delay in acceptance or refusal of vaccination despite availability of vaccination services.” 6 According to WHO, “vaccine hesitancy is complex and context specific, varying across time, place, and vaccines” and is one of the top 10 global health threats.…”

Section: Introductionmentioning

confidence: 99%