Measles, rubella, mumps, and varicella seroprevalence among health care workers in Turkey: Is prevaccination screening cost-effective?

Çelikbaş, Aysel Kocagül; Ergönül, Önder; Aksaray, Sebahat; Tuygun, Nilden; Esener, Harika; Tanır, Gönül; Eren, Selim Sırrı; Baykam, Nurcan; Guvener, Engin; Dokuzoğuz, Başak

doi:10.1016/j.ajic.2006.04.213

Cited by 60 publications

(54 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of a recent study regarding seropositivity differ from the findings of other studies. In Turkey, 98% of 363 HCWs had antibodies against varicella [16]. The immunity rates for varicella among medical students in Germany and Switzerland were 96.9% and 97%, respectively, [17,18], while in our study, only 71% of medical students were immune.…”

Section: Resultscontrasting

confidence: 40%

“…Indeed, a positive history of chickenpox better correlated with the presence of antibody than did a negative serologic test result for varicella [14,23,25]. In the populations of Brazil and Turkey, and the child population of Switzerland, the positive predictive value of the clinical history of varicella ranged from 95% to 100% [16,[31][32][33]. In the applicants for nurse training in Scotland, the positive predictive value of the history of varicella for seropositivity was 98%.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Talebi-Taher

Noori²,

Shamshiri³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: This study was designed to evaluate the immune status of health care workers against varicella zoster in a university hospital in Teheran, Iran, and to compare the history of chickenpox infection with the presence of varicella antibodies in this population. Methods: Serologic testing for varicella was performed for 405 health care workers with different job categories and at different age. The enzyme immunoassay was used for determining IgG antibodies against varicella zoster virus Results: A total of 405 health care workers, aged 19-50 years (median: 29 years), were examined. Of these, 289 (71.4%) were found to be seropositive. No statistically significant differences were observed between gender, age, or occupation, and seropositivity (p = 0.09, 0.75, 0.54. respectively). Statistical analysis revealed that the correlation between chickenpox history and seropositivity showed a 62.3% sensitivity, 72.4% specificity, 84.9% positive predictive value, and 43.5% negative predictive value. Conclusions: Serologic screening of health care workers is essential to determine their immunity to varicella, regardless of the age, occupation and history of infection. This population is recommended to be considered a target group for future immunization programs in Iran. Varicella is a common childhood disease. Nearly a 100% seropositivity to VZV has been documented in children between 11-13 years of age in the USA. An epidemiological variation is being reported between the temperate and tropical climate countries, with varicella occuring mainly among young adults in the tropical regions [2]. Key words: Health care workers, Varicella zoster infection, ImmunizationThe general adult seroprevalence rates amount to 81.3% in the United Arab Emirates, 100% in Belgium, 96.6% in Israel, 95% in Turkey, 95.5% in Spain, 50% in Sri Lanka,.Moreover, nosocomial transmission of VZV is also reported in health care workers (HCWs) [10]. It seems that A checklist was completed including demographic data and the history of varicella. Individuals with acute varicella infection, those under immunosuppressive therapy, or those having blood transfusion during the year 2008, were excluded from the study. The local ethics committee approved the study protocol, and a signed informed consent was obtained from each participant. Blood samples were collected from each individual and the separated serum was stored at -20°C prior to testing. EIA for varicella-specific IgG was performed using commercial virus-specific IgG EIA kits (varicella IgG EIA well, RADIM, Italy; sensitivity 100%, specificity 88%). Optical density values were indexed according to the manufacturer's instructions. Sera were classified as negative if the OD was less than 0.20 and as positive if it was higher than 0.70; sera with OD between 0.20 and 0.70 were considered equivocal. Equivocal values were considered negative. Statistical analysis was performed using the SPSS 13 software. After conducting descriptive statistical analyses, we used the chi square test to study t...

show abstract

Section: Resultscontrasting

confidence: 40%

Section: Resultsmentioning

confidence: 99%

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Talebi-Taher

Noori²,

Shamshiri³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Most studies have found high seropositivity to varicella among adults. These findings could be explained by the fact that varicella infections occur in childhood (16,21,22). Thus, a high seroprevalence against varicella among Gunma University students was maintained during the 2007-2012 study period, although vaccination against varicella remains voluntary in Japan.…”

Section: Discussionmentioning

confidence: 92%

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

et al. 2013

View full text Add to dashboard Cite

SUMMARY:We evaluated the seroprevalence of vaccine-preventable infectious diseases among Japanese healthcare students to create immunization guidelines. Between 2007 and 2012, a total of 1746 Japanese medical, nursing, and paramedical students were serologically screened for measles, mumps, rubella, varicella, and hepatitis B virus (HBV) antibodies at the time of admission. In 2007, the seroprevalence of measles and mumps was 52.7z and 65.6z, respectively. The seroprevalence of measles dramatically increased to 96.6z in 2009 and was then sustained at À90z. The seroprevalence of mumps gradually increased to À80.0z between 2010 and 2012. The seroprevalence of rubella remained at À90z except in 2008 (85.6z), and the seroprevalence of varicella was sustained at À92z throughout 2007-2012. The seroprevalence of HBV antibody remained at º7z during 2007-2012. Although the seroprevalence of vaccine-preventable infectious diseases among Japanese healthcare students increased during the 2007-2012 study period, a substantial number of students were susceptible to vaccine-preventable infectious diseases. Therefore, we propose targeted immunization of Japanese healthcare students using serological screening prior to clinical training.

show abstract

“…Ülkemizin farklı merkezlerinde yapılan çalışmalarda, sağ-lık çalışanlarında kızamık ve kızamıkçık seropozitiflik oranları sırasıyla %82-98 ve %98-100 arasında saptanmıştır (27)(28)(29). Cılız ve arkadaşları (30), sağlık çalışanlarında kızamık seropozitifliğini %99.7, kızamıkçık seropozitifliğini %97.0 olarak saptamışlardır.…”

Section: İrdelemeunclassified

Hepatitis A, Hepatitis B, Measles, and Rubella Seroprevalence of Healthcare Workers at Elazığ Training and Research Hospital

Özgüler¹,

Saltik-Gungor²,

Kaygusuz³

et al. 2016

Klimik Dergisi

View full text Add to dashboard Cite

Objective: Each year, three million out of 35 million healthcare workers are exposed to blood-borne pathogens percutaneously according to World Health Organization. Healthcare personnel are at further risk of being exposed to contagious infection agents and sharp injuries than normal population. To protect healthcare workers, it is necessary to scan for vaccine-preventable diseases and apply immunization programs if necessary as well as effective management for sharp injuries. Methods: Between May 2013 and October 2015, 1860 healthcare workers who applied to Healthcare Workers Outpatient Clinic of our hospital were evaluated for the study. Their demographic data and serological parameters were recorded and statistical analysis performed using SPSS 15.0 program. Results: Nine hundred sixty two (51.7%) of healthcare workers were female and 898 (48.3%) were male. It was found out that HBsAg seropositivity was 3.1%, anti-HBs seropositivity was 56.5%, anti-HAV IgG seropositivity was 92.4%, anti-measles IgG seropositivity was 99.1%, and anti-rubella IgG seropositivity was 97.7%. Sharp injuries rate was found 4.6% during the period. Conclusions: Healthcare workers have an increased rate of exposure to blood and other body fluids. So, it is necessary to screen for vaccine-preventable diseases before they start to work and they should be vaccinated if they are seronegative. Effective management for sharp injuries is also necessary.

show abstract

Measles, rubella, mumps, and varicella seroprevalence among health care workers in Turkey: Is prevaccination screening cost-effective?

Cited by 60 publications

References 19 publications

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012

Hepatitis A, Hepatitis B, Measles, and Rubella Seroprevalence of Healthcare Workers at Elazığ Training and Research Hospital

Contact Info

Product

Resources

About

Measles, rubella, mumps, and varicella seroprevalence among health care workers in Turkey: Is prevaccination screening cost-effective?

Cited by 60 publications

References 19 publications

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007&ndash;2012

Hepatitis A, Hepatitis B, Measles, and Rubella Seroprevalence of Healthcare Workers at Elazığ Training and Research Hospital

Contact Info

Product

Resources

About

Seroprevalence of Measles- and Mumps-Specific Immunoglobulin G among Japanese Healthcare Students Increased during 2007–2012