Measles Infection Despite 2-dose Vaccination in Health Care Workers

Vries, Willemien de; Plötz, Frans B.; Dorigo-Zetsma, J. W.

doi:10.1097/inf.0000000000000390

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Although documentation of appropriate vaccination is not a guarantee for 100% protection [6,[9][10][11][12][13], laboratory confirmation of immunity is also hampered by drawbacks. While the plaque reduction neutralization (PRN) test is regarded as gold standard method for measles immunity [14][15][16][17][18][19][20], the assay is technically demanding, labor-intensive and difficult to standardize between laboratories [19,21].…”

Section: Introductionmentioning

confidence: 98%

Immune status of health care workers to measles virus: evaluation of protective titers in four measles IgG EIAs

Dorigo-Zetsma

Hall

Vreeswijk

et al. 2015

Journal of Clinical Virology

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Section: Introductionmentioning

confidence: 98%

Immune status of health care workers to measles virus: evaluation of protective titers in four measles IgG EIAs

Dorigo-Zetsma

Hall

Vreeswijk

et al. 2015

Journal of Clinical Virology

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“…In our study, none of the at least twice-vaccinated cases was indicated as a likely source by other cases. A few case reports were published which document the absence of transmission from vaccinated cases [6, 7, 21]. One study described transmission from a twice-vaccinated individual with documented secondary vaccine failure [5].…”

Section: Discussionmentioning

confidence: 99%

Effect of vaccination on severity and infectiousness of measles during an outbreak in the Netherlands, 2013–2014

et al. 2020

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An outbreak of measles in the Netherlands in 2013–2014 provided an opportunity to assess the effect of MMR vaccination on severity and infectiousness of measles. Measles is notifiable in the Netherlands. We used information on vaccination, hospitalisation, complications, and most likely source(s) of infection from cases notified during the outbreak. When a case was indicated as a likely source for at least one other notified case, we defined it as infectious. We estimated the age-adjusted effect of vaccination on severity and infectiousness with logistic regression. Of 2676 notified cases, 2539 (94.9%) were unvaccinated, 121 (4.5%) were once-vaccinated and 16 (0.6%) were at least twice-vaccinated; 328 (12.3%) cases were reported to have complications and 172 (6.4%) cases were hospitalised. Measles in twice-vaccinated cases led less often to complications and/or hospitalisation than measles in unvaccinated cases (0% and 14.5%, respectively, aOR 0.1 (95% CI 0–0.89), P = 0.03). Of unvaccinated, once-vaccinated and twice-vaccinated cases, respectively, 194 (7.6%), seven (5.1%) and 0 (0%) were infectious. These differences were not statistically significant (P > 0.05). Our findings suggest a protective effect of vaccination on the occurrence of complications and/or hospitalisation as a result of measles and support the WHO recommendation of a two-dose MMR vaccination schedule.

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“…Case reports of vaccinated HCP contracting measles raise the question of whether vaccination is adequate evidence of immunity. [35][36][37] Unfortunately, available serologic assays are inadequate to assess immune status fully. Individuals with positive IgG titers have become infected with measles and mumps.…”

Section: Hepatitis B Vaccinementioning

confidence: 99%

Vaccines for Health Care Personnel

Swift

Behrman²

2019

Mayo Clinic Proceedings

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Medical Center Occupational Health (MCOH) programs must protect health care personnel (HCP) against the occupational risk of vaccine-preventable diseases. This thematic review outlines the rationale for the use of recommended vaccines in HCP; summarizes the available evidence regarding vaccine effectiveness, administration, and assessment of immunity; and provides guidance for MCOH programs navigating challenging situations.

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Measles Infection Despite 2-dose Vaccination in Health Care Workers

Cited by 4 publications

References 4 publications

Immune status of health care workers to measles virus: evaluation of protective titers in four measles IgG EIAs

Immune status of health care workers to measles virus: evaluation of protective titers in four measles IgG EIAs

Effect of vaccination on severity and infectiousness of measles during an outbreak in the Netherlands, 2013–2014

Vaccines for Health Care Personnel

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