Meandered and muddled: a systematic review on the impact of air pollution on ocular health

Muruganandam, Niveditha; Mahalingam, Sneha; Narayanan, Ramsundram; Rajadurai, Elangovan

doi:10.1007/s11356-023-27079-x

Cited by 6 publications

(1 citation statement)

References 199 publications

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“…Furthermore, recent research has brought to light the detrimental effects of PM 2.5 on the surface of the eyes, thereby contributing to the emergence of various eye conditions (Yang et al 2019 ). Studies have shown that PM 2.5 can deposit on the eyelids and eyelashes (Muruganandam et al 2023 ). Short-term or long-term exposure to an environment with excessive air quality can cause eye irritation (eye itching, tears, etc.)…”

Section: Introductionmentioning

confidence: 99%

Toxicological responses of A549 and HCE-T cells exposed to fine particulate matter at the air–liquid interface

Chen,

Ge,

Deng

et al. 2024

Environ Sci Pollut Res

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Fine particulate matter (PM2.5) can enter the human body in various ways and have adverse effects on human health. Human lungs and eyes are exposed to the air for a long time and are the first to be exposed to PM2.5. The “liquid immersion exposure method” has some limitations that prevent it from fully reflecting the toxic effects of particulate matter on the human body. In this study, the collected PM2.5 samples were chemically analyzed. An air–liquid interface (ALI) model with a high correlation to the in vivo environment was established based on human lung epithelial cells (A549) and immortalized human corneal epithelial cells (HCE-T). The VITROCELL Cloud 12 system was used to distribute PM2.5 on the cells evenly. After exposure for 6 h and 24 h, cell viability, apoptosis rate, reactive oxygen species (ROS) level, expression of inflammatory factors, and deoxyribonucleic acid (DNA) damage were measured. The results demonstrated significant dose- and time-dependent effects of PM2.5 on cell viability, cell apoptosis, ROS generation, and DNA damage at the ALI, while the inflammatory factors showed dose-dependent effects only. It should be noted that even short exposure to low doses of PM2.5 can cause cell DNA double-strand breaks and increased expression of γ-H2AX, indicating significant genotoxicity of PM2.5. Increased abundance of ROS in cells plays a crucial role in the cytotoxicity induced by PM2.5 exposure These findings emphasize the significant cellular damage and genotoxicity that may result from short-term exposure to low levels of PM2.5.

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Section: Introductionmentioning

confidence: 99%