Mean sarcomere length-force relationship of rat muscle fibre bundles

Zuurbier, Coert J.; Heslinga, J. W.; Groot, M.B.E. Lee-de; Laarse, Willem J. van der

doi:10.1016/0021-9290(95)80009-3

Cited by 48 publications

(24 citation statements)

References 15 publications

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“…After stringent washes with distilled water diaphragm strips were incubated in 26% HNO3 for 4 h to dissolve the extra‐cellular matrix. HNO3‐treated diaphragm strips were washed in distilled water and stored in 50% glycerol for 7–14 days before fibre bundle isolations started 23. Small fibre bundles were isolated with microforceps and transferred to glass slides for visualization.…”

Section: Methodsmentioning

confidence: 99%

Titin‐based mechanosensing modulates muscle hypertrophy

Pijl

Strom

Conijn

et al. 2018

J cachexia sarcopenia muscle

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BackgroundTitin is an elastic sarcomeric filament that has been proposed to play a key role in mechanosensing and trophicity of muscle. However, evidence for this proposal is scarce due to the lack of appropriate experimental models to directly test the role of titin in mechanosensing.MethodsWe used unilateral diaphragm denervation (UDD) in mice, an in vivo model in which the denervated hemidiaphragm is passively stretched by the contralateral, innervated hemidiaphragm and hypertrophy rapidly occurs.ResultsIn wildtype mice, the denervated hemidiaphragm mass increased 48 ± 3% after 6 days of UDD, due to the addition of both sarcomeres in series and in parallel. To test whether titin stiffness modulates the hypertrophy response, RBM20ΔRRM and TtnΔIAjxn mouse models were used, with decreased and increased titin stiffness, respectively. RBM20ΔRRM mice (reduced stiffness) showed a 20 ± 6% attenuated hypertrophy response, whereas the TtnΔIAjxn mice (increased stiffness) showed an 18 ± 8% exaggerated response after UDD. Thus, muscle hypertrophy scales with titin stiffness. Protein expression analysis revealed that titin‐binding proteins implicated previously in muscle trophicity were induced during UDD, MARP1 & 2, FHL1, and MuRF1.ConclusionsTitin functions as a mechanosensor that regulates muscle trophicity.

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Section: Methodsmentioning

confidence: 99%

Titin‐based mechanosensing modulates muscle hypertrophy

Pijl

Strom

Conijn

et al. 2018

J cachexia sarcopenia muscle

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“…R.E.S., unpublished), where there would be no overlap between thick and thin filaments, no contractile force could be developed (ter Keurs et al, 1978;Herzog et al, 1992;Wang et al, 1993;Zuurbier et al, 1995) and myofibrillar damage would occur (Wang et al, 1993). However, the apparent compression of muscle cells by recoiling elastin fibres (Fig.8, Table3) relieves the problem for the OS because the initial VGB deformation would uncrimp but not stretch the cells.…”

Section: How Can the Muscles Accommodate Large Vgb Strains?mentioning

confidence: 99%

Novel muscle and connective tissue design enables high extensibility and controls engulfment volume in lunge-feeding rorqual whales

Shadwick

Goldbogen

Potvin

et al. 2013

Journal of Experimental Biology

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SUMMARYMuscle serves a wide variety of mechanical functions during animal feeding and locomotion, but the performance of this tissue is limited by how far it can be extended. In rorqual whales, feeding and locomotion are integrated in a dynamic process called lunge feeding, where an enormous volume of prey-laden water is engulfed into a capacious ventral oropharyngeal cavity that is bounded superficially by skeletal muscle and ventral groove blubber (VGB). The great expansion of the cavity wall presents a mechanical challenge for the physiological limits of skeletal muscle, yet its role is considered fundamental in controlling the flux of water into the mouth. Our analyses of the functional properties and mechanical behaviour of VGB muscles revealed a crimped microstructure in an unstrained, non-feeding state that is arranged in parallel with dense and straight elastin fibres. This allows the muscles to accommodate large tissue deformations of the VGB yet still operate within the known strain limits of vertebrate skeletal muscle. VGB transverse strains in routine-feeding rorquals were substantially less than those observed in dead ones, where decomposition gas stretched the VGB to its elastic limit, evidence supporting the idea that eccentric muscle contraction modulates the rate of expansion and ultimate size of the ventral cavity during engulfment.

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“…1b) was fit to the experimental data of small rat gastrocnemius medialis (GM) fiber bundles (Zuurbier et al 1995). This function is scaled such that at optimum length, the fiber direction strain (ε 22 ) is zero and the maximal stress value is unity.…”

Section: Myofiber Elementmentioning

confidence: 99%

Finite element modeling of aponeurotomy: altered intramuscular myofascial force transmission yields complex sarcomere length distributions determining acute effects

Yücesoy

Koopman

Grootenboer

et al. 2006

Biomech Model Mechanobiol

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Finite element modeling of aponeurotomized rat extensor digitorium longus muscle was performed to investigate the acute effects of proximal aponeurotomy. The specific goal was to assess the changes in lengths of sarcomeres within aponeurotomized muscle and to explain how the intervention leads to alterations in muscle length-force characteristics. Major changes in muscle length-active force characteristics were shown for the aponeurotomized muscle modeled with (1) only a discontinuity in the proximal aponeurosis and (2) with additional discontinuities of the muscles' extracellular matrix (i.e., when both myotendinous and myofascial force transmission mechanisms are interfered with). After muscle lengthening, two cut ends of the aponeurosis were separated by a gap. After intervention (1), only active slack length increased (by approximately 0.9 mm) and limited reductions in muscle active force were found (e.g., muscle optimum force decreased by only 1%) After intervention (2) active slack increased further (by 1.2 mm) and optimum length as well (by 2.0 mm) shifted and the range

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Mean sarcomere length-force relationship of rat muscle fibre bundles

Cited by 48 publications

References 15 publications

Titin‐based mechanosensing modulates muscle hypertrophy

Titin‐based mechanosensing modulates muscle hypertrophy

Novel muscle and connective tissue design enables high extensibility and controls engulfment volume in lunge-feeding rorqual whales

Finite element modeling of aponeurotomy: altered intramuscular myofascial force transmission yields complex sarcomere length distributions determining acute effects

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