Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients

Lano, Guillaume; Sallée, Marion; Pelletier, M.; Bataille, Stanislas; Fraissé, Megan; Berda-Haddad, Yaël; Brunet, Philippe; Burtey, Stéphane

doi:10.3390/jcm8050608

Cited by 8 publications

(12 citation statements)

References 39 publications

(43 reference statements)

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“…Sarioglu, et al, menemukan bahwa tingginya rasio trombositlimfosit mungkin mendukung temuan adanya stenosis dan trombosis Arteriovenous fistula (Sarioglu, et al, 2019). Lano G, et al (2019), melakukan studi mengenai mean platelet volume (MPV) pada pasien hemodialisis dimana mereka menyimpulkan bahwa insiden disfungsi akses vaskuler tinggi pada pasien dengan kadar MPV yang tinggi. Chang CJ, et al (2005), mengamati bahwa infiltrasi oleh makrofag dan limfosit dalam lapisan vaskular dari AVF yang obstruksi menyebabkan peningkatan aktivitas inflamasi.…”

Section: Pendahuluanunclassified

“…Pada trombositopenia perifer akut, MPV meningkat akibat produksi trombosit muda yang berhubungan dengan aktivasi megakariosit. Sedangkan pada trombositopenia kronis, MPV yang lebih tinggi berhubungan dengan adanya trombopati (Lano, et al, 2019). Sarioglu, et al (2019) dalam penelitiannya menemukan tingginya level rasio trombositlimfosit bisa menjadi faktor pendukung terbentuknya stenosis dan thrombosis pada pasien gagal AVF.…”

Section: Pembahasanunclassified

“…Penelitian lain yang dilakukan Lano, et al (2019) menunjukkan bahwa kejadian disfungsi akses vaskular lebih tinggi pada pasien dengan MPV tertinggi (p-value=0.001) dimana resiko kejadian kegagalan akses vaskular 3 kali lebih tinggi pada pasien dengan MPV yang tinggi dibandingkan dengan pasien MPV yang rendah. Sehingga, peneliti menyebutkan bahwa MPV dapat dijadikan biomarker disfungsi akses vaskular dan membantu klinis dalam mengidentifikasi populasi beresiko tinggi.…”

Section: Pembahasanunclassified

“…Pada aliran darah, adhesi trombosit meningkat seiring dengan pertambahan hematokrit. Sehingga, fraksi volume eritrosit memiliki pengaruh terhadap hemostasis dan thrombosis (Lano, et al, 2019)).…”

Section: Pembahasanunclassified

“…Peneliti menyimpulkan pada pasien dengan kadar hematokrit tinggi berperan penting terjadinya hiperkoagulasi dalam darah dan ini memicu terjadinya thrombus dan gagal AVF, karena pada penelitian ini terdapat bahwa nilai hematokrit >36% angka kegagalan 4 orang (100%) pada AVF pertama pasien GGk yang akan dihemodialisa dan secara statistik signifikan dengan p-value=0,003 (Lano, et al, 2019).…”

Section: Pembahasanunclassified

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Hubungan Nilai Trombosit dan Hematokrit dengan Kegagalan Arteriovenous Fistula pada Pasien Gagal Ginjal

Satria

Rustam

Rivaldy

2020

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Hemodialysis is a treatment for kidney failure that uses a machine to send the patient's blood through a filter. Arteriovenous fistulas (AVF) and arteriovenous grafts are vascular access that is designed for long-term use. In the world, the number of patients with end-stage chronic kidney failure (CRF) which requires hemodialysis is increasing. However, almost 50% of arteriovenous fistulas can never be used for hemodialysis, and if they can be used, 25% will experience failure after 2 years. Many factors make the AVF failure, between the injury of the endothelial wall or the hypercoagulation. This study uses a cross-sectional retrospective design. Data is taken from the medical record status of patients with chronic kidney failure in RSUP Dr. M.Djamil Padang from January 2017-December 2019. Data were analyzed by Chi-square and Fisher test. From a sample of 33 people, patients obtained hematocrit values <33%, 33-36%,> 36% failure of AVF as many as 8, 2, and 4 people. While the platelet values <150,000,150,000-400,000 and 400,000 obtained AVF failures were 0.9 and 5 people. There was no relationship of platelet values with AVF failure in hemodialysis patients with p-value=0,323. There was a correlation between hematocrit values and AVF failure in hemodialysis patients with p-value=0,003.

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Hubungan Nilai Trombosit dan Hematokrit dengan Kegagalan Arteriovenous Fistula pada Pasien Gagal Ginjal

Satria

Rustam

Rivaldy

2020

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The predictive value of systemic inflammatory markers in 902 patients with tunneled hemodialysis catheter

Baykara Ulusan,

Meltem,

Mutlu

et al. 2024

J Nephrol

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Aim This study aimed to assess the predictive role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and mean platelet volume, on catheter survival in chronic hemodialysis patients, analyzing both infectious and non-infectious complications. Methods A retrospective analysis encompassed 1279 tunneled catheter insertion procedures involving 902 patients between March 2014 and October 2018. Patients were categorized into two main groups: (i) initial placement and (ii) exchange. The exchange group was further stratified into four subgroups: infection, dysfunction, displacement, and transitioning temporary hemodialysis catheters to long-term ones. Hematologic ratios were calculated from baseline hemogram data, including neutrophil, lymphocyte, monocyte, and platelet counts, while mean platelet volume was derived from the same hemogram. Results The patients in the exchange group displayed significantly higher lymphocyte and monocyte values (p < 0.001), while lower values were noted for neutrophil–lymphocyte ratio and platelet-lymphocyte ratio (p < 0.001). The transition group displayed higher monocyte values and lower mean platelet volume and lymphocyte-monocyte ratio values (p < 0.05). In the infection-related exchange subgroup, higher neutrophil count, mean platelet volume, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio values were observed compared to other groups (p < 0.05). Cases related to catheter dysfunction exhibited increased lymphocyte-monocyte ratio but lower neutrophil, monocyte, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio values (p < 0.05). Conclusion This study highlights the interest of specific inflammatory markers, particularly monocytes, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio, in the management of tunneled catheters, notably in patients undergoing exchanges. However, cut-off values, essential for constructing management algorithms, are currently lacking, and prospective multicenter studies are needed for further elucidation. Graphical abstract

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Percutaneous rheolytic thrombectomy of thrombosed arteriovenous dialysis access using the AngioJet catheter- A Systematic Review

Lee,

Ho Dominic,

et al. 2024

Preprint

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The endovascular removal of thrombi in occluded arteriovenous (AV) access sites has been increasingly accepted by surgeons as an alternative to surgical thrombectomy and revision [1,2]. This systematic review documents the experiences and outcomes of using the AngioJet Rheolytic Thrombectomy Device for salvaging thrombosed arteriovenous fistulas (AVFs) or grafts (AVGs). Electronic databases, such as PubMed, Embase, and the Cochrane Library, were searched from their establishment until May 2024. Initially, 549 articles were reviewed for potential inclusion, and only 10 studies fulfilled our inclusion criteria. Our final dataset included 771 patients who underwent 996 thrombectomies to treat 338 thrombosed AVFs and 457 AVGs. The demographics, technical and procedural success, patency rates, and complications were evaluated to examine the effectiveness and safeness of AngioJet thrombectomy. The mean primary patency rates at 3, 6, and 12 months were 64.09 +- 10.12, 50.36 +- 11.73, and 40.81 +- 15.13 (p < 0.05). The mean assisted primary patency rates at 3, 6, and 12 months were 75.37 +- 13.98, 59.58 +- 14.26 and 40.88 +- 18.81 (p < 0.05). Finally, the mean secondary patency rates at 3, 6, and 12 months were 84.03+- 8.38, 77.93 +- 9.07, and 65.81 +- 12.12 (p < 0.05). A total of 92 complications were recorded; most were minor complications, thereby being transient and self-limiting. Additionally, 5 total deaths were reported; however, all were not considered related to the AngioJet device. Our study deemed devices such as AngioJet efficacious in performing pharmacomechanical thrombectomies, as promising results in terms of safeness and effectiveness to re-establish patency in occluded AVFs and AVGs have been reported.

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Mean Platelet Volume Predicts Vascular Access Events in Hemodialysis Patients

Cited by 8 publications

References 39 publications

Hubungan Nilai Trombosit dan Hematokrit dengan Kegagalan Arteriovenous Fistula pada Pasien Gagal Ginjal

Hubungan Nilai Trombosit dan Hematokrit dengan Kegagalan Arteriovenous Fistula pada Pasien Gagal Ginjal

The predictive value of systemic inflammatory markers in 902 patients with tunneled hemodialysis catheter

Percutaneous rheolytic thrombectomy of thrombosed arteriovenous dialysis access using the AngioJet catheter- A Systematic Review

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