Mean platelet volume predicts survival in patients with hepatocellular carcinoma and type 2 diabetes

Yin, Ji bin; Niu, Yucun; Qian, Li yan; Zhang, Xin; Liu, Zhi Ping; Wang, Rui Tao

doi:10.1016/j.diabres.2019.04.012

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…In addition, for patients with colon cancer and lung cancer, an increase in MPV implies a poor prognosis. 28 In studies related to HCC, the ratio of mean platelet volume to platelet is found significantly elevated in HCC patients, 29 low-level MPV might be one of the risk indicators for liver cancer recurrence after liver transplantation, 30 and for patients with liver cirrhosis and those who cannot undergo resection, patients with advanced HCC, those with thrombocytopenia and higher MPV have longer survival times. 31 …”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Novel Prognostic Nomogram Based on Platelet and CD8+T Cell Counts in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis

Shi,

Yan,

Liu

et al. 2024

JHC

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Section: Discussionmentioning

confidence: 99%

Development and Validation of a Novel Prognostic Nomogram Based on Platelet and CD8+T Cell Counts in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis

Shi,

Yan,

Liu

et al. 2024

JHC

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“…In addition, serum miR-4297 was positively correlated with mean platelet volume (MPV) in the female subgroup. As a routine hematological index of the average platelet size, it has been gradually recognized that MPV would reflect the inflammation response in different clinical settings more than the platelet function ( 38 , 39 ). We have excluded patients with chronic inflammatory conditions from the current study so that the potential confounding factors on MPV were minimized.…”

Section: Discussionmentioning

confidence: 99%

Serum microRNA-4297 is a sex-specific predictive biomarker of glioma grade and prognosis

Huang²,

Xie³

et al. 2022

Front. Neurol.

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BackgroundGliomas account for nearly 80% of brain cancers, tending to occur more frequently in men with adverse outcomes. Emerging microRNAs have been positioned as promising predictors for glioma's histological grade and prognosis. However, there have been few studies concerning the sex-biased impacts on the clinical approach for the potential microRNA-4297 (miR-4297).MethodsWe utilized GSE139031micro-RNAs profiling to analyze serum miR-4297 expression in glioma. A total of 114 newly diagnosed glioma patients at the First Affiliated Hospital of Fujian Medical University from January 2017 to February 2021 were recruited and prospectively followed up. The association of miR-4297 levels with glioma grade and prognosis was investigated. Luciferase reporter gene assays and genotype analyses were carried out to explore the potential mechanism of sexually dimorphic miR-4297 in glioma.ResultsSerum miR-4297 levels were notably down-regulated in glioma. Besides, serum miR-4297 levels were positively associated with the high grades, which were exclusively present for females. The positive correlations of miR-4297 with O6-methylguanine-DNA methyltransferase (MGMT) protein and mean platelet volume were also observed in females. IDH-mutant females had decreased miR-4297. Median PFS time for females with miR-4297 ≥ 1.392 was distinctly shorter than those with miR-4297 <1.392 (12.3 months vs. 42.89 months, p = 0.0289). Based on multivariate logistic regression, miR-4297-based equation model was established as FHGRS. AU-ROC analysis revealed FHGRS exhibited a robust performance in predicting high-grade glioma in females (p < 0.001), whereas there was no such relationship in males. Furthermore, the MGMT-3'UTR variant rs7896488 in the specific binding region of miR-4297 was correlated with prognosis.ConclusionOur study uncovers sex-dependent characterization of serum miR-4297 in predicting glioma grade and the relapse risk for female patients, which underscores the clinical benefits of sex-specific analysis in non-coding RNA research.

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“…Tumors can induce platelet activation, and activated platelets could promote tumor progression and metastasis [5]. Mean platelet volume (MPV) is considered an indicator of platelet activation and decreased MPV is a poor prognostic marker for many cancers [6][7][8]. MPV is significantly reduced in the MSI-H subtype of CRC [9,10].…”

Section: Introductionmentioning

confidence: 99%

Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study

et al. 2022

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Background As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of innate immune cells. Patients with different microsatellite statuses have distinct immune profiles. This study aimed to investigate the association of plasma CLEC-2 levels with microsatellite status among colorectal cancer (CRC) patients. Methods A cross-sectional analysis of 430 CRC patients from Harbin Medical University Cancer Hospital was conducted. CLEC-2 levels were measured with fasting venous blood samples drawn from each participant before any treatment. The microsatellite status was evaluated with DNA obtained from fresh frozen tumor tissue samples. The other clinical data were collected and recorded based on the medical system records. Results CLEC-2 levels were significantly higher among patients with high microsatellite instability phenotype than the stable microsatellite group, adjusting for other confounding variables. Conclusions The increased CLEC-2 is associated with the high microsatellite instability subtype of CRC.

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Mean platelet volume predicts survival in patients with hepatocellular carcinoma and type 2 diabetes

Cited by 5 publications

References 33 publications

Development and Validation of a Novel Prognostic Nomogram Based on Platelet and CD8+T Cell Counts in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis

Development and Validation of a Novel Prognostic Nomogram Based on Platelet and CD8+T Cell Counts in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis

Serum microRNA-4297 is a sex-specific predictive biomarker of glioma grade and prognosis

Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study

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