Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction

Abstract

Mean platelets volume (MPV) has been shown to correlate with impaired reperfusion and increased mortality in patients with ST-elevation myocardial infarction (STEMI) treated with primary precutaneous coronary intervention (PCI). We aimed to study whether the same association exists in STEMI patients treated with thrombolysis. Included in the study were STEMI patients receiving thrombolysis. Thrombolysis failure was defined as a need for rescue precutaneous coronary intervention (PCI), in-hospital mortality, unplanned PCI during hospitalization or complete occlusion of the culprit coronary artery in a follow-up angiography. MPV levels were compared between patients with failed or successful thrombolysis. Of the 122 patients, 30 had failed thrombolysis while the other 92 fulfilled the criteria for successful treatment. There were no significant differences in demographic or clinical baseline characteristics of the two groups. Mean MPV was significantly higher in patients with failed thrombolysis compared to patients with successful treatment (9.2 +/- 1.1fl and 8.7 +/- 1.0fl respectively, p = 0.019 in multivariate analysis). The prevalence of thrombolysis failure was significantly higher in patients with MPV > 8.6 fl compared to those with MPV </= 8.6 fl (31.8% and 16% respectively, p = 0.048 in multivariate analysis). It appears that higher MPV correlates with thrombolysis failure in patients presenting with STEMI. MPV may be used as an adjunctive readily available factor for assessing thrombolysis outcome upon admission.

Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study

“…In one of them, MPV was found to be elevated in patients with STEMI (20). In another, Pereg et al (21) found an association between unsuccessful thrombolytic therapy and an increased MPV in patients with STEMI. Also, Chu et al (22) reported an association between MPV and acute myocardial infarction in a recent meta-analysis.…”

Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction

“…In the study by Pereg et al (25) it was reported that thrombolysis failure defined as lack of ST-segment resolution at 90 minutes and need for rescue PCI, in-hospital mortality, unplanned PCI during hospitalization or complete occlusion of the culprit artery in a follow up angiography was significantly higher in patients with elevated MPV. But specific data about the relationship between MPV and ST -segment resolution has not been mentioned in that study.…”

The relationship between TIMI flow grade and hematological parameters in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention

“…Başka bir çalışmada, perkutan girişim ile tedavi edilen STEMI'lı hastalarda MPV'nin, kötü anjiografik reperfüzyon ve mortalitenin bağımsız bir göstergesi olduğu gösterilmiştir (34). STEMI'lı hastalarda yapılan başka bir çalışmada, başarısız trombolitik tedavi ve MPV arasında ilişki bulunmuştur (35). PCI yapılan STEMI'lı hastalarda, infarkt ilişkili arterin açıklığının tahmininde MPV'nin faydalı olabileceği bildirilmiştir (36).…”