Mean platelet volume (MPV): could it be used as a predictive marker for mortality in post cardiac arrest patients undergoing targeted temperature management?

Abstract

Objective: Current guidelines recommend a period of moderate targeted temperature management (TTM) for post cardiac arrest patients (PCA) to improve clinical outcomes. A prognostic value related to survival in patients receiving TTM was not fully established. In this study, we aimed to investigate the relationship between mean platelet volume (MPV) and mortality in PCA patients undergoing TTM. Method: This was a single-center, retrospective cohort study included 15 patients who suffered from cardiac arrest and underwent TTM within 6 hours of cardiac arrest. Hypothermia was maintained for 48h at a target temperature of 34°C. We examined all data about characteristic features of PCA patients s as well as MPV within the first 96 hours from admission. Results: Of the 15 patients, 11 (73.3%) died during hospital stay. At time points of T0, T1, T2, T3, T4 24 hour ie. a total of 5 times hemogram values were determined. The change of all values except red cell distribution width (RDW) values over time was found to be significant (P<0.05).When surviving patients were evaluated relative to deceased patients only MPV T1, T2 and T4 values showed statistically significant changes. As MPV cut-off value of T4 7.63 was determined (AUC=1.00, 95% CI:1.00-1.00, p=0.004 with a sensitivity and specificity of 100% and 100%, respectively). Conclusion:The second day values of MPV after TTM is an independent predictor of survival in PCA patients treated with TTM. Changes in MPV can be used to predict survival in these patients.

Letter to the editor: Mean platelet volume may not be a predictive marker for mortality in post cardiac arrest patients undergoing targeted temperature management

“…Sayın Editör, Karahan ve ark. (1) tarafından gerçekleştirilen kalp durması sonrası hedefe yönelik hipotermi uygulanan hastalarda ortalama trombosit hacminin (OTH) mortalite için bir belirteç olup olamayacağının değerlendirildiği retrospektif araştırmayı büyük bir ilgi ile okuduk. OTH değerlerindeki değişimlerin kalp durması sonrası hedefe yönelik hipotermi uygulanan hastalarda sağkalımın bağımsız bir belirleyicisi olduğunu savunan bu çalışmanın sonuçlarını olumsuz bir şekilde etkileyebilecek çeşitli faktörler olduğuna inanıyoruz.…”