Mean Platelet Volume is a Significant Biomarker in the Differential Diagnosis of Acute Appendicitis

Aktimur, Recep; Çetinkünar, Süleyman; Yıldırım, Kadir; Özdaş, Sabri; Aktimur, Sude Hatun; Gökakın, Ali Kağan

doi:10.14800/ics.930

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…When MPV and PDW used for the diagnosis of acute appendicitis, different results were obtained. In some studies, it was stated that these values increase, while others decrease or do not differ [21][22][23][24]. In our study, we found that MPV value increased and PDW value decreased in patients with AA.…”

Section: Discussionsupporting

confidence: 54%

The Correlation between Complete Blood Count Parameters and Appendix Diameter for the Diagnosis of Acute Appendicitis

Daldal

Dagmura

2020

Healthcare

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Acute appendicitis is one of the most common causes of acute abdominal diseases seen between the ages of 10 and 19, mostly seen in males. The lifetime risk of developing acute appendicitis is 8.6% for males and 6.7% for females. We aimed to investigate the efficacy of the complete blood count parameters, C-reactive protein, and Lymphocyte-C-reactive Protein Ratio laboratory tests in the diagnosis of acute appendicitis, as well as their relationship with appendix diameter. We retrospectively examined all patients who underwent appendectomy between 1 January 2012 and 30 June 2019 in the General Surgery Clinic of Gaziosmanpasa University Faculty of Medicine. Laboratory tests, imaging findings, age, and gender were recorded. Lymphoid hyperplasia is considered as normal appendix—in other words, as negative appendicitis. The distribution of Lymphoid hyperplasia and appendicitis rates were statistically different in the groups formed according to appendix diameter (≤6 and >6 mm) (p < 0.001). We found a significant correlation between appendix diameter and WBC (White blood count), Lymphocyte, Neutrophil, RDW(Red blood cell distribution width), NLR(Neutrophil to lymphocyte ratio), and PLT/L (Platelet to lymphocyte ratio), MPV (Mean platelet volume) and RDW were significantly different in patients with an appendix diameter of ≤6 mm (p = 0.007, p = 0.006, respectively). WBC, Neutrophil, PDW, and NLR values were significantly different between appendicitis and hyperplasia groups in patients with an appendix diameter of >6 mm. The sensitivity of the NLR score (cutoff = 2.6057) in the diagnosis of appendicitis was 86.1% and selectivity was 50% in these patients. Complete blood count parameters evaluation with the clinical findings revealed that NLR is an important parameter that may help the diagnosis of acute appendicitis with an appendix diameter of >6 mm. In patients whose pathological results indicated acute appendicitis but who had a diameter of ≤6 mm, we found an elevated MPV and low RDW values.

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Section: Discussionsupporting

confidence: 54%

The Correlation between Complete Blood Count Parameters and Appendix Diameter for the Diagnosis of Acute Appendicitis

Daldal

Dagmura

2020

Healthcare

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“…The RDW in our study was found to be 14.71±1.64, which was not significant (i.e., p=0.442 and p>0.05). Similar results were observed in the other studies conducted by Aktimur et al 1 and Tanrikulu et al 21 . However, it was noted that RDW was elevated in the perforated group when compared to the acute group, similar to the study by Boshnak et al 4 , which shows the high-grade inflammatory pathology of perforated appendicitis, and thus can be used as a predictive indicator.…”

Section: Discussionsupporting

confidence: 92%

“…Similar results were observed in the other studies conducted by Aktimur etal. 1 and Tanrikulu etal. 21 .…”

Section: Discussionmentioning

confidence: 95%

“…The results were comparable to those obtained in the study by Aktimur etal. 1 The quantity of platelets changes during an acute inflammatory process, causing bigger platelets to enter the circulation and, as a result, a spike in subsequent PDW levels. Young platelets enter the peripheral circulation when MPV and PDW are higher than controls.…”

Section: Discussionmentioning

confidence: 99%

“…Walter de Biase SILVA-NETO 1 , Claudemiro QUIRESE 1 , Eduardo Guimarães Horneaux de MOURA 2 , Fabricio Ferreira COELHO 3 , Paulo HERMAN 3 ABSTRACT -Background: The treatment of choice for patients with schistosomiasis with previous episode of varices is bleeding esophagogastric devascularization and splenectomy (EGDS) in association with postoperative endoscopic therapy. However, studies have shown varices recurrence especially after long-term follow-up.…”

Section: A Queda Da Pressão Portal Após Desvascularização Esofagogást...mentioning

confidence: 99%

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Diagnosis of Acute Appendicitis and Appendicular Perforation: Evaluation of Platelet Indices and Red Cell Distribution Width as Emerging Biomarkers

AG,

PATIL

2023

ABCD, arq. bras. cir. dig.

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BACKGROUND: Acute appendicitis is a common surgical emergency worldwide. Recent studies on hematological inflammatory markers concerning acute appendicitis have shown variable results. AIMS: The aim of this study was to evaluate pre-operative values of platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW), and red cell distribution width (RDW) in relation to the diagnosis of acute appendicitis and their efficacy as predictors of appendicular perforation. METHODS: A prospective observational study of 190 patients diagnosed with appendicitis and who underwent an appendectomy was undertaken and confirmed histopathologically. Preoperatively, blood samples of white blood cells (WBCs), platelet count, MPV, PDW, and RDW were analyzed using a Sysmex XN1000 analyzer machine. RESULTS: Of 190 patients, 169 had acute appendicitis, and 21 had perforated appendicitis. The mean age of patients was 28.04 ± 14.2 years. The male-to-female ratio was 1.5:1. The WBC (p<0.05), MPV (p<0.05), and PDW (p<0.05) were found to have higher statistically significant values in acute appendicitis and perforated appendicitis compared to the RDW (p>0.05). However, perforated appendicitis had a higher RDW value compared to acute appendicitis, which can be a predictive factor. CONCLUSIONS: The elevated value of MPV and PDW associated with leukocytosis can be used as supportive evidence for the clinical and radiological diagnosis of acute appendicitis and appendicular perforation. Thus, these values can be used as diagnostic cost-effective inflammatory biomarkers.

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A novel and simple machine learning algorithm for preoperative diagnosis of acute appendicitis in children

Aydın

Türkmen

Namli³

et al. 2020

Pediatr Surg Int

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BackgroundThere is a tendency toward nonoperative management of appendicitis resulting in an increasing need for preoperative diagnosis and classification. For medical purposes, simple conceptual decision-making models that can learn are widely used. Decision trees are reliable and effective techniques which provide high classification accuracy. We tested if we could detect appendicitis and differentiate uncomplicated from complicated cases using machine learning algorithms. MethodsWe analyzed all cases admitted between 2010 and 2016 that fell into the following categories: healthy controls (Group 1); sham controls (Group 2); sham disease (Group 3), and acute abdomen (Group 4). The latter group was further divided into four groups: false laparotomy; uncomplicated appendicitis; complicated appendicitis without abscess, and complicated appendicitis with abscess. Patients with comorbidities and whose complete blood count and/or pathology results were lacking were excluded. Data were collected for demographics, preoperative blood analysis, and postoperative diagnosis. Various machine learning algorithms were applied to detect appendicitis patients. ResultsThere were 7244 patients with a mean age of 6.84±5.31 years, of whom 82.3% (5960/7244) were male. Most algorithms tested, especially linear methods, provided similar performance measures. We preferred the decision tree model due to its easier interpretability. With this algorithm, we detected appendicitis patients with 93.97 % area under the curve (AUC), 94.69% accuracy, 93.55% sensitivity, and 96.55% specificity, and uncomplicated appendicitis with 79.47% AUC, 70.83% accuracy, 66.81% sensitivity, and 81.88% specificity. ConclusionsMachine learning is a novel approach to prevent unnecessary operations and decrease the burden of appendicitis both for patients and health systems.

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Mean Platelet Volume is a Significant Biomarker in the Differential Diagnosis of Acute Appendicitis

Cited by 6 publications

References 29 publications

The Correlation between Complete Blood Count Parameters and Appendix Diameter for the Diagnosis of Acute Appendicitis

The Correlation between Complete Blood Count Parameters and Appendix Diameter for the Diagnosis of Acute Appendicitis

Diagnosis of Acute Appendicitis and Appendicular Perforation: Evaluation of Platelet Indices and Red Cell Distribution Width as Emerging Biomarkers

A novel and simple machine learning algorithm for preoperative diagnosis of acute appendicitis in children

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