Mean platelet volume increased in children with asthma

Doğru, Mahmut; Aktas, Alev; Öztürkmen, Seda

doi:10.1111/pai.12381

Cited by 17 publications

(27 citation statements)

References 9 publications

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“…(9) found MPV to be higher in patients with asthma compared to healthy individuals. Tuncel et al (11) compared the MPV values between patients who had asthma attack and healthy individuals and found no significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 93%

“…Platelets are involved in all steps including obstruction in the airways, airway inflammation and bronchial hypersensitivity in asthma. In patients with asthma, an increase in MPV has been found during asthma attack (9). Platelet volume indices which are known to change in inflammatory, infectious and allergic diseases may be helpful measurements in evaluation of patients with acute bronchiolitis arising from inflammatory obstruction of small airways characterized with bronchial inflammation who constitute a significant part of hospitalizations in the childhood.…”

Section: Introductionmentioning

confidence: 99%

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Reduction in mean platelet volume in children with acute bronchiolitis

et al. 2016

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Aim: Platelets which are known to play a role in inflamation change their shapes when they are activated and this change is reflected in mean platelet volume and platelet distribution width values. Therefore, the mean platelet volume and platelet distribution width values are considered to be beneficial parameters for the diagnosis and treatment of many inflammatory diseases. The aim of the study was to evaluate platelet volume indices in children with acute bronchiolitis. Material and Methods:A total of 514 infants who were below the age of 2 years old were evaluated in this study. Three hundred thirteen of these infants were diagnosed with acute bronchiolitis patients and 201 were healthy children. The patients were separated into four groups as mild, moderate, severe bronchiolitis and the control patient group. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results. Results:The mean platelet volume was found to be 6.8±0.6 fL in the patients with mild bronchiolitis attack, 6.7±0.6 fL in the patients with moderate bronchiolitis attack, 6.5±0.5 fL in the patients with severe bronchiolitis attack and 7.3±1.1 fL in the control group. The mean platalet volume was statistically significantly lower in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The platelet distribution width was found to be 17.2%±0.83 in the mild bronchiolitis attack group, 17.1%±0.96 in the moderate bronchiolitis attack group, 17.3%±0.87 in the severe bronchiolitis attack group and 16.9±1.6% in the control patient group. This difference was not statistically significant (p=0.159). The platelet count was statistically significantly higher in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000).

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Reduction in mean platelet volume in children with acute bronchiolitis

et al. 2016

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“…), se ha considerado como un marcador de la activación con cambios en el VPM. 8,9,24 Sin embargo, hasta donde se sabe, aún no se ha investigado la función de los trombocitos en los pacientes con PAIPD. En nuestro estudio, se determinó que el VPM y el VPR en los pacientes con PAIPD estaban significativamente elevados.…”

Section: Discussionunclassified

“…7 El volumen plaquetario medio (VPM) es un valor de la activación plaquetaria y puede emplearse como marcador en la inflamación. 8,9 En la bibliografía no se ha encontrado ningún estudio sobre la función del INL y el VPM, que son marcadores no invasivos fáciles de medir, en los pacientes con PAIPD.…”

Section: Introductionunclassified

Marcadores de inflamación y desarrollo de tolerancia en la proctocolitis alérgica

2018

Arch Argent Pediatr

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RESUMENAntecedentes: Con el incremento de la proctocolitis alérgica inducida por proteínas de la dieta (PAIPD), son necesarios estudios que aclaren su fisiopatología y determinar marcadores no invasivos y sencillos para el diagnóstico y la evaluación del desarrollo de tolerancia. No hallamos estudios publicados sobre la función del índice de neutrófilos/ linfocitos (INL) y el volumen plaquetario medio (VPM), que son marcadores no invasivos fácilmente medibles, en pacientes con PAIPD. Objetivos: Determinar la relación entre el INL y el VPM con el diagnóstico y desarrollo de tolerancia en niños con PAIPD. Métodos: Estudio transversal retrospectivo, los datos se obtuvieron del sistema de registros médicos, los síntomas y los resultados de laboratorio de los pacientes con diagnóstico de PAIPD fueron controlados en los consultorios de alergia y gastroenterología. Se compararon valores del hemograma al momento del diagnóstico con el grupo de niños sanos de edad y sexo similares. Resultados: Entre los 59 pacientes con diagnóstico de PAIPD, los varones representaron el 47,4% y las niñas, el 52,6%. El VPM y el volumen plaquetario relativo (VPR) eran significativamente más altos entre los pacientes con PAIPD en comparación con el grupo de referencia (n: 67) (p < 0,001). Asimismo, VPM y el VPR fueron significativamente elevados en pacientes que no desarrollaron tolerancia comparados con los que la desarrollaron (p= 0,01). Con el INL no hubo diferencias entre los grupos. Conclusiones: El VPM y el VPR se consideraron marcadores adecuados para predecir el pronóstico de los pacientes con PAIPD dado que son rápidos, costo-efectivos y fáciles de medir. Palabras clave: alergia alimentaria, inducida por proteínas, proctocolitis, volumen plaquetario medio, inflamación.

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“…7 Mean platelet volume (MPV) is a value of platelet activation and it is used as a marker in inflammation. 8,9 No study has been found in the literature about the place of FPIAP of NLR and MPV, which are easy to calculate and non-invasive markers.…”

Section: Introductionmentioning

confidence: 99%

Markers of inflammation and tolerance development in allergic proctocolitis

Nacaroğlu

Erdem

Durgun

et al. 2018

Arch Argent Pediatr

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Background. Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive markers in both diagnosis, and evaluation of the development of tolerance. No study has been found in the literature about the place of neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV), which are easy to calculate and non-invasive markers. Objectives. The purpose is to determine the relation between NLR and MPV with the diagnosis and development of tolerance in children with FPIAP. Methods. In this retrospective cross-sectional study, clinical, demographic symptoms and laboratory findings of patients, monitored with FPIAP diagnosis in allergy and gastroenterology clinics, were acquired from the patient record system. Hemogram values at the time of diagnosis were compared with the values of healthy children of the same age and gender. Results. Among 59 patients diagnosed with FPIAP, males constitute 47.4% and females constitute 52.6%. MPV and platelet crit (PCT) values were significantly high when compared to the control group (n: 67) in FPIAP cases (p <0.001). Also, MPV and PCT values were significantly high in non-tolerance developing cases when compared to developing ones (p= 0.01). Conclusions. Contrary to NLR, MPV and PCT values have been considered to be good markers in predicting prognosis in cases with FPIAP since they are quick, cost effective and easy to calculate.

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Mean platelet volume increased in children with asthma

Cited by 17 publications

References 9 publications

Reduction in mean platelet volume in children with acute bronchiolitis

Reduction in mean platelet volume in children with acute bronchiolitis

Marcadores de inflamación y desarrollo de tolerancia en la proctocolitis alérgica

Markers of inflammation and tolerance development in allergic proctocolitis

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