Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease

Tavıl, Yusuf; Şen, Nihat; Yazici, Hüseyin; Hizal, Fatma; Abacı, Adnan; Çengel, Atiye

doi:10.1016/j.thromres.2006.10.005

Cited by 148 publications

(128 citation statements)

References 30 publications

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“…23 Elevated MPV values have also been reported to correlate with a higher prevalence of metabolic syndrome. 24 In the present investigation, positive correlations were found between MPV and the prevalence of hyperlipidemia. Furthermore, inflammation may induce platelet activation, which increases MPV.…”

Section: Discussionsupporting

confidence: 61%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

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Mean platelet volume (MPV) is increased in various cardiovascular diseases. We sought to determine the prognostic value of MPV for hypertension. We performed a retrospective cohort study. Baseline characteristics were measured in 9168 individuals without hypertension, and the follow-up period was 9 years. Hypertension was confirmed in 2881 participants during the followup period. When the participants were grouped according to MPV quartiles, the hazard ratio of future hypertension gradually increased across the MPV quartiles. The hazard ratios of hypertension for the II, III and IV (high) vs. I (low) quartiles of MPV were 1.13 (95% confidence interval (CI) 1.01-1.25, P = 0.027), 1.25 (95% CI 1.12-1.39, Po0.001) and 1.40 (95% CI 1.26-1.55, Po0.001), respectively. In multivariate Cox regression analysis, MPV predicted hypertension independently of age, sex, platelet count, waist circumference, drinking, systolic blood pressure and creatinine levels. The present study indicated that elevated MPV is associated with increased incidence of hypertension independent of other risk factors, which suggests that platelet activity may play a role in hypertension incidence.

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Section: Discussionsupporting

confidence: 61%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

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“…9,10 This alteration can be detected by platelets indices such as platelet count and platelet volume in relation with increasing fasting glucose levels. 4,5 In the current study large sample comprising of 3471 were taken into consideration and ADA criteria of impaired fasting glucose (IFG) was adopted and values of PC as well as MPV were studied. As per this criteria threshold levels for IFG was lowered up to 100-125 mg/dl of fasting plasma glucose in 2003 for better prediction of future diabetes incidence.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume: An economical diagnostic marker of cardiovascular risk assessment in altered fasting blood glucose levels

Kapoor¹,

Kaur

Rana

et al. 2015

Asian J Med Sci

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Background: Platelets with altered morphology or large size are more thrombogenic and are likely to be associated with increased risk of vascular disease. Platelet parameters especially high mean platelet volume (MPV) has been reported in diabetic patients as major contributing factor. The aim of the present study was to find correlation between fasting blood glucose value and hematological variables (PC and MPV), not only in diabetics, but also in the normoglycemic subjects and patients with impaired fasting blood glucose levels. Materials and Methods: In the present study 3471 subjects were analyzed retrospectively and categorized into three groups based on the fasting blood glucose levels as Group I -normoglycemics (FBG ≤ 109 mg/dl, n = 1158), Group II-impaired fasting blood glucose (FBG ≤ 126 mg/dl, n = 1158) and Group III -Diabetics (FBG ≥ 127 mg/dl, n = 1155). Results: We found progressive increase in value of MPV with the increasing FBG levels, in the following order: G1 (8.44 ± 0.842 fl), G2 (8.98 ± 0.898 fl), G3 (9.31 ± 0.967 fl). The platelet count however, did not show much statistical significance with rising glucose levels. Conclusions: MPV increased proportionally with increasing plasma glucose levels. Although the variation between the normoglycemics and impaired fasting group was not very significant, the parameters still showed progressive increase with rising sugar levels significant in diabetic group.

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“…MPV, an accurate measure of platelet size, reflects the activity of platelets (4). Moreover, increased MPV is now emerging as an independent risk factor for CVD (5).…”

Section: Discussionmentioning

confidence: 99%

Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

Kaygusuz¹,

Simavlı²,

Eser³

et al. 2014

Turk J Med Sci

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Background/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods:This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population.Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion:Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

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Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease

Cited by 148 publications

References 30 publications

Association between mean platelet volume and hypertension incidence

Association between mean platelet volume and hypertension incidence

Mean platelet volume: An economical diagnostic marker of cardiovascular risk assessment in altered fasting blood glucose levels

Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

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