Mean platelet volume in patients with obstructive sleep apnea syndrome and its relationship with cardiovascular diseases

Abstract

Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for the development of cardiovascular events and hypertension. Mean platelet volume (MPV), an indicator of platelet activation and aggregation, is closely related with cardiovascular diseases (CVDs). We aimed to show the relationship between OSAS and MPV with CVD. The medical records of 205 patients who were admitted to the sleep study were evaluated. OSAS was diagnosed by polysomnography if the apnea-hypopnea index (AHI) was greater than 5. MPV was calculated from blood samples. According to AHI, individuals in whom AHI was less than 5 were recruited as the control group, those in whom AHI was 5-15 as the mild OSAS group, those in whom AHI was equal to 15-30 as the moderate OSAS group, and those in whom AHI was greater than 30 as the severe OSAS group. Of the patients, 137 (67%) were men and 68 (33%) were women; the mean age was 53.0±14.1 years. There were 35 (17%), 20 (10.2%), 42 (20.4%), and 108 (52.6%) participants in groups 1, 2, 3, and 4, respectively. There were significant differences in terms of coronary artery disease and hypertension between all groups (P<0.05). There was a significant association between the severity of OSAS and MPV in groups 3 and 4, whereas there was not any association in groups 1 and 2 (group 1=9.3±0.7, group 2=9.4±0.8, group 3=9.5±1.1, group 4=10.2±1.2; P for trend 0.03). We showed that MPV was significantly increased in patients with OSAS, which is an independent risk factor for CVD. Therefore, MPV could be used as a marker to predict CVD in OSAS.

Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome

“…Elevated cardiovascular disease incidence in OSAS might be due to impaired hypercoagulation and elevated plated activation observed in these patients. [5] In OSAS, platelets possibly become active through three mechanisms. [6] First, night hypoxemias and recurring wake ups result in sympathetic system activation characterized by epinephrine and norepinephrine increase.…”

“…In many studies, platelet activation and aggregation have been reported to increase in patients with OSAS. [5,6] Mean platelet volume (MPV) is a parameter used as an indicator of platelet activation. Larger platelets are more reactive than normal-sized ones and have higher prothrombotic potentials.…”

“…Mean platelet volume is considered as a marker of atherosclerosis. [5][6][7][8][9][10] In previous studies, MPV has been reported to increase in adult cerebrovascular and cardiovascular conditions such as hypertension, unstable angina pectoris, myocardial infarction and stroke. [9] It has been shown that elevated MPV levels could be associated with the prognoses of these diseases.…”

Association between mean platelet volume and hypertension incidence

“…29,30 These factors may contribute to the association between MPV and hypertension. When participants were stratified by platelet count, the highest MPV was significantly associated with an increased incidence of hypertension.…”

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

“…In many studies, platelet activation and aggregation have been reported to increase in patients with OSAS. 12,13 Mean platelet volume (MPV) is a parameter used as an indicator of platelet activation. Larger platelets are more reactive than normal-sized ones and have higher prothrombotic potentials.…”