Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris

Yang, Alexander; Pizzulli, Luciano; Lüderitz, Berndt

doi:10.1016/j.thromres.2005.04.004

Cited by 99 publications

(90 citation statements)

References 49 publications

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“…We found a significant inverse correlation between platelet count and mean platelet volume, in agreePlatelet indices in the general population haematologica | 2011; 96 (8) 1185 [20][21][22] or platelet distribution width. This finding could be explained by the possibility that, in order to maintain constant platelet functional mass, 23 platelet count would be decreased in the presence of bigger platelets.…”

Section: Discussionsupporting

confidence: 82%

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

152

100

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The online version of this article has a Supplementary Appendix. BackgroundThe understanding of non-genetic regulation of platelet indices -platelet count, plateletcrit, mean platelet volume, and platelet distribution width -is limited. The association of these platelet indices with a number of biochemical, environmental and clinical variables was studied in a large cohort of the general population. Design and MethodsMen and women (n=18,097, 52% women, 56±12 years) were randomly recruited from various villages in Molise (Italy) in the framework of the population-based cohort study "Moli-sani". Hemochromocytometric analyses were performed using an automatic analyzer (Beckman Coulter, IL, Milan, Italy). Associations of platelet indices with dependent variables were investigated by multivariable linear regression analysis. ResultsFull models including age, sex, body mass index, blood pressure, smoking, menopause, white and red blood cell counts, mean corpuscular volume, D-dimers, C-reactive protein, high-density lipoproteins, low-density lipoproteins, triglycerides, glucose, and drug use explained 16%, 21%, 1.9% and 4.7% of platelet count, plateletcrit, mean platelet volume and platelet distribution width variability, respectively; variables that appeared to be most strongly associated were white blood cell count, age, and sex. Platelet count, mean platelet volume and plateletcrit were positively associated with white blood cell count, while platelet distribution width was negatively associated with white blood cell count. Platelet count and plateletcrit were also positively associated with C-reactive protein and D-dimers (P<0.0001). Each of the other variables, although associated with platelet indices in a statistically significant manner, only explained less than 0.5% of their variability. Platelet indices varied across Molise villages, independently of any other platelet count determinant or characteristics of the villages. ConclusionsThe association of platelet indices with white blood cell count, C-reactive protein and Ddimers in a general population underline the relation between platelets and inflammation.Key words: platelet, inflammation, C-reactive protein, white blood cells, age, gender. Citation: Santimone I, Di Castelnuovo A, De Curtis A, Spinelli M, Cugino D, Gianfagna F, Zito F, Donati MB, Cerletti C, de Gaetano G and Iacoviello L on behalf of the Moli-sani ProjectInvestigators.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica 2011;96(8):1180-1188. doi:10.3324/haematol.2011 This is an open-access paper.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

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Section: Discussionsupporting

confidence: 82%

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

152

100

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“…In the study of Huczek et al (2005), MPVs measured during acute MI had an highly significant relationship with increased mortality in following six months and increased number of no-reflow cases during primary PTCA. Also other researches showed significant associations between MPV values measured during acute STEMI and long term prognosis (Yang et al, 2006). In our study, on the other hand, there was no significant relationship between MPV and MACE rates despite a mild elevation in MPV values.…”

Section: Discussioncontrasting

confidence: 57%

Relationship between cardiovascular evaluation data on admission and secondary adverse cardiac event rate after acute coronary syndrome

Civan¹,

Özcan²,

Zıyrek³

et al. 2014

jecm

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Article HistoryReceived 30 / 10 / 2013 Accepted 08 / 06 / 2014The current study aimed to investigate the relationship of clinical data with mean platelet volume (MPV) and QT dispersion values on admission of acute coronary syndrome (ACS) patients to the adverse cardiac event rate in a follow-up period of 20 months after discharge. For this purpose demographic and clinical data with corrected QT dispersion on admission and MPV values of 97 consequtive patients with ACS were recorded, retrospectively. Their history of major adverse cardiac event (MACE) in a 20 months period after ACS was obtained from the hospital records, interviews with the attending physicians and telephone calls to patients. Demographic and clinical data with corrected QT dispersion on admission, and MPV values were compared between groups with and without MACE in terms of statistical significance. In our study, diabetesmellitus, left ventricular ejection fraction (EF) and wall motion score index (WMSI), corrected QT dispersion, total cholesterol, LDL, CK-MB and troponin levels were found significantly related to the secondary MACE rate (p values; 0.046, 0.0001, 0.0001, 0.032, 0.024, 0.002 and 0.0001, respectively). No significant relation was detected between groups with and without MACE in terms of conservative medical follow-up and revascularization history (p=0.774). In the comparison of mean MPV values, there was no statistically significant difference between MPV values of patients with MACE (10.4±1.8 fl) and without MACE (10.3±2 fl) (p=0.799). In addition, the subgroup analysis on acute ST-elevation myocardial infarction cases in our study group did not state a significant relationship between MPV values below/above 10.3 fl and MACE rates (p=0.774). Finally, this retrospective study showed that corrected QT dispersion, diabetes, contractile reserve of left ventricule, total and LDL-cholesterol and peak cardiac enzyme values assessed during ACS might predict MACE.

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“…Platelets play a pivotal role in atherothrombosis, the major cause of most unstable coronary syndromes and increased MPV levels have been shown as an indicator in myocardial infarcts [4,[11][12][13], congestive heart disease [13], cerebrovascular diseases [14], obesity [15] and hypertensive patients [16,17]. There is a previous study that suggested a relationship between high MPV levels and an increase in the frequency of restenosis in patients who received coronary angioplasty [18]. Another study has also shown a relationship between increased MPV and increased CAD incidence in chronic hemodialysis patients [19].…”

Section: Discussionmentioning

confidence: 99%

Increased mean platelet volume in type 2 diabetes mellitus

Yenigun¹

2014

Diclemedj

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Diyabetik hastalarda vasküler komplikasyonların gelişiminde trombositler önemli rol oynamaktadır. Büyük trombositler küçüklere oranla daha aktif olup, ortalama trombosit hacmi (MPV) trombosit aktivitesini göstermede kullanılan bir belirteçdir. Biz bu çalışmamızda MPV'nin tip 2 diyabetes mellituslu hastalarda ve diyabetin mikrovasküler ve makrovasküler komplikasyonlardaki ilişkisi araştırmayı amaçladık. Yöntemler: Çalışmaya Dışkapı Eğitim ve Araştırma Hastanesi Dahiliye polikliniğinde takipli olan 48 tip 2 diyabetli ve 30 sağlıklı hasta dahil edilmiştir. Tüm hastalarda tam kan sayımı, açlık kan şekeri ve lipid parametreleri çalışıldı. Diyabetik hastalarda diyabet süresi, HbA1c düzeyi, mikrovasküler ve makrovasküler komplikasyon varlığı araştırıldı. Ortalama trombosit hacmi diyabetik ve sağlıklı kontrol grubu arasında ve diyabetik kolda komplikasyon olan olmayan grup arasında karşılaştırıldı. Bulgular: Diyabetik hastalarda MPV, non-diyabetik sağlıklılarla karşılaştırıldığında anlamlı yüksek saptandı. En az bir mikrovasküler komplikasyonu olan hastalarda olmayanlara göre MPV belirgin yüksek saptandı. Makrovasküler komplikasyonu olan hastalarda MPV olmayan hastalara göre yüksek bulundu. Sonuç: Hem diyabetiklerde hem de mikro-makrovasküler komplikasyonları olan diyabetik hastalarda MPV yüksek bulunmuştur.

show abstract

Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris

Cited by 99 publications

References 49 publications

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Relationship between cardiovascular evaluation data on admission and secondary adverse cardiac event rate after acute coronary syndrome

Increased mean platelet volume in type 2 diabetes mellitus

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