Mean platelet volume as a novel predictor of systemic inflammatory response in cirrhotic patients with culture-negative neutrocytic ascites

Galvez-Martínez, Marisol; Servín-Caamaño, A.; Pérez-Torres, Eduardo; Salas-Gordillo, F.; Rivera-Gutiérrez, Xaira; Tijera, Fátima Higuera-de la

doi:10.4254/wjh.v7.i7.1001

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…The studies also suggest that the MPV increases more in cirrhotic patients with infections especially SBP and that it is affected by the severity of the systemic inflammatory response syndrome (SIRS) associated with these infections. MPV can be the earliest laboratory tests that can provide a rapid diagnostic tool for AFI even before you perform ascetic fluid sampling and examination [8].…”

Section: Introductionmentioning

confidence: 99%

The role of mean platelet volume in the diagnosis of spontaneous bacterial peritonitis

Abdelkader

Jouda

2019

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aim: Spontaneous bacterial peritonitis is a serious condition that needs rapid diagnosis and rapid management due to its serious sequelae. SBP is diagnosed when the polymorphonuclear cells count in the ascetic fluid exceeds 250 cell/µL. Mean platelet volume (MPV) was found to be significantly larger in the cirrhotic patients with ascetic fluid infection than cirrhotic patients without ascetic fluid infection. In our study we aimed to assess the role and clinical performance of MPV as a diagnostic marker of SBP. Patients and Methods: This cross sectional study was performed on 124 cirrhotic patients with ascites. They were classified into two groups according to ascetic fluid PMN count into two groups. Group I: 38 patients with ascetic fluid infection, PMN >250 cell/µL and group II: 86 patients without ascetic fluid infection, PMN count <250 cells/µL. Results: The MPV was significantly higher among patients with ascetic fluid infection (11.1±1.2 vs 9.4±1.1 p<0.001). Blotting the ROC curve, MPV was proved to diagnose SBP at a cut off value of 10.45 fL with sensitivity and specificity of 74.4% and 78.9% respectively. Conclusion: MPV is a useful diagnostic marker that can predict the presence of SBP in cirrhotic patients with ascites.

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Section: Introductionmentioning

confidence: 99%

The role of mean platelet volume in the diagnosis of spontaneous bacterial peritonitis

Abdelkader

Jouda

2019

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Section: Mpv and Brucellosismentioning

confidence: 99%

“…MPV levels have been found higher in cirrhotic patients with AFI than in those without bacterial infection or in healthy controls [16,28]. And also, MPV has been described as a diagnostic predictor for AFI and a novel and useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI [16,28]. Whereas no significant relation between MPV and Dengue fever has been demonstrated, increased MPV values in malaria have been defined as a useful predictive marker for severity of infection [12,29].…”

Section: Mpv and Brucellosismentioning

confidence: 99%

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

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Mean platelet volume (MPV), a parameter of complete blood count analysis, measures the average size of platelets. The alterations of MPV levels have been described as a diagnostic or prognostic predictor in patients with infectious diseases including sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis, ascites fluid infection, hepatitis B or hepatitis C in recent studies. Although some matters still remain unclear, it can be said that MPV, especially in a scoring system, may be a cost-effective and useful marker for monitoring and predicting outcomes in patients with some infectious diseases in the future.

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“…While no Child-A case was identified, there were more Child C cases than Child-B cases. According to the study fulfilled by Galvez-Martinez et al [11] they detected no clear difference in ages between the SAI+ and SAI-groups, but they showed significant elevation for the female sex among all cases. Additionally, as in our study, the highest rate was found for culture negative neutrocytic ascites.…”

Section: Discussionmentioning

confidence: 87%

The relationship between the mean platelet volume and the development of spontaneous ascites fluid infection in patients with decompensated cirrhosis

Böyük¹

2020

South Clin Ist Euras

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Spontaneous ascitic fluid infection (SAI) is one of the frequent and important complication of decompensated cirrhosis with high mortality. Mean platelet volume (MPV) is a parameter that shows the activity, stimulation and production of platelets. Changes in MPV are important indicators of platelet production, and are also an indicator of the severity of many diseases, such as sepsis, thrombosis, or even respiratory distress syndrome. In our study, we aimed to analyze the relationship between spontaneous ascites infection and mean platelet volume.Methods: 98 cirrhosis patients (42 females, 56 males) with various etiologies were participated to the study. The patients were divided into two groups as SAI positive group including patients with ascitic culture positive and/or ascites polymorphonuclear leukocyte count (PMNL) >250 mm 3 and SAI negative group including patients with no bacterial reproduction in their ascites fluid culture and ascites PMNL count <250 mm 3 .Results: There were 52 patients as 19 females and 33 males, in SAI positive group and 46 patients as 23 females and 23 males, in SAI negative group. In spontaneous ascites infectionpositive group, spontaneous ascites infection mean platelet volume (p<0.001) and leukocyte count (WBC) (p<0.001) were detected to be significantly different statistically compared to the negative group. There was no statistically significant difference between the mean platelet volume (p=0.795) and platelet distribution percentage (p=0.775) in SAI positive patients (p>0.05). Conclusion:Mean platelet volume in patients with spontaneous ascites infection who have developed, decompensated cirrhosis significantly increases. It is possible to use this test which is cheap, non-invasive and fast in the early diagnosis and treatment to follow-up of spontaneous ascites infection.

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Mean platelet volume as a novel predictor of systemic inflammatory response in cirrhotic patients with culture-negative neutrocytic ascites

Abstract: Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA.

Cited by 10 publications

References 27 publications

The role of mean platelet volume in the diagnosis of spontaneous bacterial peritonitis

The role of mean platelet volume in the diagnosis of spontaneous bacterial peritonitis

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

The relationship between the mean platelet volume and the development of spontaneous ascites fluid infection in patients with decompensated cirrhosis

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