Mean Platelet Volume and Vitamin D Level

Cüre, Medine Cumhur; Yüce, Süleyman; Yazici, Tarkan; Karakoyun, İnanç; Efe, Hasan

doi:10.3343/alm.2014.34.2.98

Cited by 58 publications

(50 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the VD levels had no relationship with systolic and diastolic BP and HR. In our country, the VD levels are frequently lower than in many other countries [13,14]; therefore, subjects in both the PCOS and control groups had in general low VD levels. Although the BP in the PCOS group was higher than in the control group, it was classified as being at a high-normal level.…”

Section: Discussionmentioning

confidence: 99%

“…A VD deficiency leads to hypertension through many mechanisms, including an activated renin-angiotensin system, impaired glycemic control and hyperinsulinemia, and elevated inflammatory cytokines [14]. Previous studies conducted on PCOS subjects have reported the correlation between the decreased VD levels and both IR and increased LH [16].…”

Section: Discussionmentioning

confidence: 99%

“…The defect in calcium metabolism and the production of proinflammatory cytokines during a VD deficiency are blamed for the development of many diseases. A VD deficiency has been reported to play a role in the development of diabetes, cancer, hypertension, and atherosclerosis [14,15]. Some studies have also reported low VD levels in POCS patients [16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

Self Cite

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. It affects nearly 5-10% of young women. It is characterized by the presence of hirsutism, acne, anovulation, hyperandrogenism, polycystic ovaries, and infertility [1]. Many mechanisms have been reported to be responsible for the pathophysiology of PCOS. The condition is thought to be determined by complex interactions between the hypothalamic-pituitary-ovarian or hypothalamic-pituitary-adrenal axis functions and metabolic disorders, such as obesity, insulin resistance (IR), and compensatory hyperinsulinemia [2]. PCOS increases the prevalence of hyperglycemia, hypertension, and dyslipidemia [3], increasing thus the risk of developing cardiovascular diseases [4].Nesfatin-1 (N1) is derived from nucleobindin 2 (NUCB2), which is encoded by the NUCB2 gene. It is a newly identified peptide that has 82 amino acids [5]. It is released from several tissues including forebrain, hindbrain, brainstem, spinal cord, adipose tissues [6]. It has an anorexigenic effect and plays an important role in hypothalamic pathways such as regulating food intake, energy homeostasis, water intake, and body temperature [7,8]. In addition, it exerts cardiovascular and hypertensive effects [9]. It is closely related to glucose, insulin metabolism, and IR [5,10]. Several studies have demonstrated N1 to be associated with body mass index (BMI), IR, inflammatory stimulation in diabetes, hypertension, and PCOS [9][10][11]. It may also affect the control of the reproduction system, e.g. puberty onset and gonadotropin secretion [12]. ABSTRACTObesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR). This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram. The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone. Elevated N1 and decreased VD levels may...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

Self Cite

View full text Add to dashboard Cite

show abstract

“…We found only one study which was conducted on adults that investigated the relationship vitamin D and MPV values. In that study, they found that low levels of vitamin D (β=-0.109, p=0.019) were independently associated with increased MPV (17). Finally, the authors suggested a strong association between a low vitamin D level and a high MPV, and stated that vitamin D deficiency may be associated with increased MPV.…”

Section: Mean ± Sds (Min-max) Mean ± Sds (Min-max) Mean ± Sds (Min-max)mentioning

confidence: 79%

Mean Platelet Volume and Vitamin D Deficiency

Bala¹,

Doğan²,

Kaba³

et al. 2016

jpr

View full text Add to dashboard Cite

86 ABS TRACT Materials and Methods:This was a retrospective study. The children followed-up at the pediatrics endocrinology polyclinic and diagnosed as nutritional rickets were included in this study. The patient group was created, and by screening the files of 478 case files, those compatible with the patient group for age and gender, were taken as the control group. Results: A total of 684 children and adolescents cases between the ages 0.1-18 years were included in the study. The cases were divided into 3 groups according to the vitamin D levels. Those with vitamin D levels of less than 15 ng/mL were classified as the vitamin D deficiency group, those between 15-20 ng/mL were classified as the insufficiency group, and those between 20-100 ng/mL were classified as the normal Vitamin D level group. There was no statistically significant difference between the groups in terms of age and gender. There was no significant difference observed between the groups in terms of the MPV levels. There was no statistically significant correlation determined in the correlation analysis between the vitamin D level and the MPV (p>0.05). In the multiple regression analysis, it was observed that vitamin D had no statistically significant effect on MPV. In the performed partial correlation analysis, when hemoglobin, hematocrit, calcium, phosphorus and parathyroid hormone were selected as controlling factors, again, there was no statistically significant correlation observed between the MPV and the vitamin D (r=-0.19, p>0.05). Conclusion:In the pathophysiology of the cardiac dysfunctions appearing as a result of vitamin D deficiency, we wished to emphasize that the hypothesis of the probable effect of vitamin D on MPV should be questioned in more detail.

show abstract

“…In a transgenic mouse model, the selective elimination of vit D receptors from endothelial cells provides evidence of the importance of vit D in regulating endothelium-dependent vasoreactivity, regulating arterial blood pressure, and alteration of the arterial ECM (25). Furthermore, low levels of vit D have been linked to inflammation, increases in oxidative stress, profibrotic vascular effects, increased vascular stiffness, and decreased vasoreactivity (4,7,17,19). However, modest supplementation of vit D in healthy neonates has also been correlated with negative impacts vascular remodeling.…”

Section: Discussionmentioning

confidence: 99%

Intrauterine endotoxin-induced impairs pulmonary vascular function and right ventricular performance in infant rats and improvement with early vitamin D therapy

Mandell

Powers

Harral

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

-High pulmonary vascular resistance (PVR), proximal pulmonary artery (PA) impedance, and right ventricular (RV) afterload due to remodeling contribute to the pathogenesis and severity of pulmonary hypertension (PH). Intra-amniotic exposure to endotoxin (ETX) causes sustained PH and high mortality in rat pups at birth, which are associated with impaired vascular growth and RV hypertrophy in survivors. Treatment of ETX-exposed pups with antenatal vitamin D (vit D) improves survival and lung growth, but the effects of ETX exposure on RV-PA coupling in the neonatal lung are unknown. We hypothesized that intrauterine ETX impairs RV-PA coupling through sustained abnormalities of PA stiffening and RV performance that are attenuated with vit D therapy. Fetal rats were exposed to intraamniotic injections of ETX, ETXϩvit D, or saline at 20 days gestation (term ϭ 22 days). At postnatal day 14, pups had pressure-volume measurements of the RV and isolated proximal PA, respectively. Lung homogenates were assayed for extracellular matrix (ECM) composition by Western blot. We found that ETX lungs contain decreased ␣-elastin, lysyl oxidase, collagen I, and collagen III proteins (P Ͻ 0.05) compared control and ETXϩvit D lungs. ETX-exposed animals have increased RV mechanical stroke work (P Ͻ 0.05 vs. control and ETXϩvit D) and elastic potential energy (P Ͻ 0.05 vs. control and ETXϩvit D). Mechanical stiffness and ECM remodeling are increased in the PA (P Ͻ 0.05 vs. control and ETXϩvit D). We conclude that intrauterine exposure of fetal rats to ETX during late gestation causes persistent impairment of RV-PA coupling throughout infancy that can be prevented with early vit D treatment.chorioamnionitis; bronchopulmonary dysplasia; extracellular matrix; vascular remodeling; arterial stiffening CHANGES IN HEMODYNAMIC COMPONENTS, such as pulmonary vascular resistance (PVR), proximal pulmonary artery (PA) impedance, and right ventricular (RV) afterload, to the pathogenesis of pulmonary hypertension (PH) as bronchopulmonary dysplasia (BPD) in the neonate are not well defined and could offer insight into the mechanisms of the disease and treatment. PVR, a measure of heart workload, is a long established measure of pulmonary hypertension progression (1,2,15,16,31). PVR measures the resistance to flow and clinically describes the degree of vasoconstriction or angiogenic development of the distal vasculature. More recently, proximal PA stiffness has increasing interest as an important indicator of disease progression (20,32,35,36). Proximal PA stiffness through extracellular matrix (ECM) remodeling increases impedance that increase RV afterload (9,14). Both PVR and impedance components contribute to the pathogenesis and RV dysfunction in PH (35) but are poorly understood in the setting of BPD. Furthermore, neonatal complications of BPD have been clinically associated with global RV structural and functional differences in adult life (21), motivating the need to understand RV-PA function in the neonate.Chorioamnionitis, a disease characterized...

show abstract

Mean Platelet Volume and Vitamin D Level

Cited by 58 publications

References 40 publications

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Mean Platelet Volume and Vitamin D Deficiency

Intrauterine endotoxin-induced impairs pulmonary vascular function and right ventricular performance in infant rats and improvement with early vitamin D therapy

Contact Info

Product

Resources

About