Mean Platelet Volume and Platelet Count in Patients with Type 2 Diabetes Mellitus and Impaired Fasting Glucose

Bhatta, Sushama; Singh, Samir; Gautam, Santosh; Osti, Bidur Prasad

doi:10.33314/jnhrc.v16i41.1502

Cited by 5 publications

(2 citation statements)

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“…Fatty liver is related to metabolic syndrome [28]. However, a study showed no correlation between hyperglycemia and platelet count [29]. In the present study, fatty liver could not be known from primary data.…”

Section: Discussioncontrasting

confidence: 56%

Factors Associated with Significant Platelet Count Improvement in Thrombocytopenic Chronic Hepatitis C Patients Receiving Direct-Acting Antivirals

Chen

Chang

Chen

et al. 2022

Viruses

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To clarify the predictive factors of significant platelet count improvement in thrombocytopenic chronic hepatitis C (CHC) patients. CHC patients with baseline platelet counts of <150 × 103/μL receiving direct-acting antiviral (DAA) therapy with at least 12-weeks post-treatment follow-up (PTW12) were enrolled. Significant platelet count improvement was defined as a ≥10% increase in platelet counts at PTW12 from baseline. Platelet count evolution at treatment week 4, end-of-treatment, PTW12, and PTW48 was evaluated. This study included 4922 patients. Sustained virologic response after 12 weeks post-treatment was achieved in 98.7% of patients. Platelet counts from baseline, treatment week 4, and end-of-treatment to PTW12 were 108.8 ± 30.2, 121.9 ± 41.1, 123.1 ± 43.0, and 121.1 ± 40.8 × 103/μL, respectively. Overall, 2230 patients (45.3%) showed significant platelet count improvement. Multivariable analysis revealed that age (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.99–1.00, p = 0.01), diabetes mellitus (DM) (OR = 1.20, 95% CI: 1.06–1.38, p = 0.007), cirrhosis (OR = 0.66, 95% CI: 0.58–0.75, p < 0.0001), baseline platelet counts (OR = 0.99, 95% CI: 0.98–0.99, p < 0.0001), and baseline total bilirubin level (OR = 0.80, 95% CI: 0.71–0.91, p = 0.0003) were independent predictive factors of significant platelet count improvement. Subgroup analyses showed that patients with significant platelet count improvement and sustained virologic responses, regardless of advanced fibrosis, had a significant increase in platelet counts from baseline to treatment week 4, end-of-treatment, PTW12, and PTW48. Young age, presence of DM, absence of cirrhosis, reduced baseline platelet counts, and reduced baseline total bilirubin levels were associated with significant platelet count improvement after DAA therapy in thrombocytopenic CHC patients.

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Section: Discussioncontrasting

confidence: 56%

Factors Associated with Significant Platelet Count Improvement in Thrombocytopenic Chronic Hepatitis C Patients Receiving Direct-Acting Antivirals

Chen

Chang

Chen

et al. 2022

Viruses

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“…13 Furthermore, contradicting evidence suggests no connection and dependence between platelet and DN. 14 The 2004-2009 Rio de Janeiro research comprised 689 people with T2DM. The neutrophil-to-lymphocyte ratio, monocyte-to-high-density lipoprotein ratio, and monocyte count ratio were all linked to cardiovascular deaths, whereas the lymphocyte-to-monocyte ratio was safe and protective.…”

Section: Literature Reviewmentioning

confidence: 99%

Association of Hematological Parameters and Diabetic Neuropathy: A Retrospective Study

AlShareef,

Alrawaili,

Almutairi

et al. 2024

DMSO

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Background: Diabetic neuropathy (DN) is a common complication of type 2 diabetes (T2DM) and is characterized by persistent inflammation. Hematological parameters have emerged as a novel marker for detecting chronic inflammatory conditions, including diabetes. Aim: We aim to examine the association between HbA1c levels, which can indicate the presence of diabetic neuropathy, and hematological parameters to explore the possibility of using hematological parameters as a new indicator for DN in T2DM patients. Methods: This was a retrospective study of 768 (483 males and 284 females) medical records of adult T2DM patients with or without neuropathy who attending the outpatient neuromuscular clinic at King Abdul-Aziz University Hospital from January 2016 to December 2021. Results:The results showed significant increases in HbA1c levels (p=0.000), lymphocyte levels (p=0.028), and the neutrophillymphocyte ratio (NLR) (p=0.011). In the T2DM group, HBA1C levels were found to be positively correlated with age (r=0.306, p=0.000), neutrophil (NEUT) (r=0. 287, p=0.000), platelet (PLT) (r=0. 148, p=0.039), and neutrophil-lymphocyte ratio (NLR) (r=0.306193, p=0.0007), and negatively correlated with gender (r=−0.306193, p=0.0007). In the T2DMN group, HBA1C levels showed a positive correlation with hemoglobin (HB) (r=0.084, p=0.045), PLT (r=0.087, p=0.037), and PLT/mean corpuscular hemoglobin (MCH) ratio (PLT/MCH ratio) (r=0.12, p=0.004), and a negative correlation with age (r=−0.204, p=0.000), gender (r= −0.086, p=0.041), weight (WT) (r=−0.113, p=0.007), Body Surface Area (BSA) (r=−0.09, p=0.031), mean corpuscular volume (MCV) (r=−0.292, p=0.000), and MCH (r=−0.186, p=0.000). Conclusion:Our study found a significant association between HbA1c, a biomarker for diabetic neuropathy, and various hematological parameters (HB, MCV, MCH, PLT, PLT/MCH ratio) in T2DMN patients. By effectively controlling and monitoring these variables, it may be feasible to prevent or delay the progression of peripheral neuropathy in diabetic patients. However, further research is needed to validate these findings.Plain Language Summary: DN is nerve damage induced by elevated blood glucose levels in T2DM. It is a common condition that affects patients by increasing the chance of falling, causing discomfort, and decreasing their quality of life. It is one of the most ubiquitous consequences of diabetes. Symptoms include limb numbness, tingling, weakness, and severe pain and sensitivity. Longterm microvascular effects of diabetes mellitus include retinopathy, nephropathy, and neuropathy. This study was done to evaluate the effects of DN on hematological parameters. The haematological parameters study aims to identify a relationship between HbA1c and DN. The researchers determined clinical data through clinical records including age, gender, WT, BSA, and laboratory data included HbA1c, HB, MCHC, MCV, MCH, PLT, RDW, HCT, NEUT, LYMPH, NLR, PLR, and PLT/MCH ratio. Statistical analysis was applied after data collection. As a result, this retrospective study ident...

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Research Progress on Platelet and Aging-Related Diseases

李¹

2022

ACM

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Mean Platelet Volume and Platelet Count in Patients with Type 2 Diabetes Mellitus and Impaired Fasting Glucose

Cited by 5 publications

References 0 publications

Factors Associated with Significant Platelet Count Improvement in Thrombocytopenic Chronic Hepatitis C Patients Receiving Direct-Acting Antivirals

Factors Associated with Significant Platelet Count Improvement in Thrombocytopenic Chronic Hepatitis C Patients Receiving Direct-Acting Antivirals

Association of Hematological Parameters and Diabetic Neuropathy: A Retrospective Study

Research Progress on Platelet and Aging-Related Diseases

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