Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Zhou, Zhongwei; Chen, Hongmei; Sun, Mingzhong; Ju, Huixiang

doi:10.1155/2018/1985026

Cited by 26 publications

(21 citation statements)

References 42 publications

(39 reference statements)

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“…MPV values of GDM patients were found to be significantly increased compared to healthy pregnant women, while the other platelet parameters were the same [17]. Other studies showed that neither PC nor MPV values were different between GDM and control group similar to our study results [18][19][20]. Zou and et al studied a systematic review and meta-analysis which included 1361 patients with GDM and 1911 healthy pregnant women.…”

Section: Discussionsupporting

confidence: 86%

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Mpv for Predicting Gestational Diabetes Mellitus

Karaca¹,

Yaşar²,

Ilıman³

et al. 2019

JDMC

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Objective: In this study we aimed to compare blood count parameters such as; mean platelet volume (MPV), platelet count (PC), and platelet distribution width (PDW), white blood count (WBC), hemoglobin (HMG), hematocrit (HCT), lymphocyte (LYM ), neutrophil (NEU), PC/MPV, PC/LYM, PC/WBC, NEU/LYM rates; between healthy pregnant women and pregnant women with Gestational Diabetes Mellitus (GDM) whether these parameters have a predictive value of GDM. Methods: A retrospective case control study was performed and a total of 202 pregnant women including 78 pregnant women with GDM (38.6%) and 124 healthy pregnant women (61.4%; the control group) were fallen under the study. Prior medical histories had no particularity. Results: The result of compared parameters between GDM and Control Groups; there was no significant difference between any variables except age (p=0.024; p<0.05). Conclusion: If blood samples are evaluated under healthy conditions ( rapidly collection, transfer and studying) we concluded that blood count parameters would not be useful for predicting the diagnosis of GDM.

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Section: Discussionsupporting

confidence: 86%

“…However; due to not only the using of the varied diagnostic criteria but also the heterogeneity of the patient groups that included in the studies; there was a potential bias. Consequently; outcomes were not clear in this meta-analysis [18] .…”

Section: Discussionmentioning

confidence: 80%

Mpv for Predicting Gestational Diabetes Mellitus

Karaca¹,

Yaşar²,

Ilıman³

et al. 2019

JDMC

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“…[22] Platelet indices including MPV, PDW, PCT and indices such as PLR and NLR have been shown to be affected in GDM patients. [8][9][10][11][12] However, the results are contradictory as there are numerous studies that reported no difference in these parameters. [10,[14][15][16][17] Similarly, there are contradictory results with respect to WBC and red blood cells.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Some investigators focused on the inflammatory markers as there is chronic low-grade inflammation that triggers vascular injury and dysfunction and subsequent platelet activation in GDM. [6,7] Recently because, systemic inflammatory response markers that are components of complete blood count test (CBC) including neutrophilto-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), [8][9][10] platelet indices including platelet count, mean platelet volume (MPV) platelet distribution width (PDW), plateletcrit (PCT), [11,12] white blood cells, red blood cells [13] are suggested to differ in GDM patients in different studies. However, in some other studies these results could not be confirmed.…”

Section: Introductionmentioning

confidence: 99%

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Aytan

Babuş

Sakarya

et al. 2020

Journal of Contemporary Medicine

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To assess the role of simple complete blood count (CBC) in prediction of gestational diabetes (GDM). Material and Method: Pregnant women screened for GDM in 24-28 gestational weeks with a 75g-OGTT between January 2018-January 2020 were retrospectively investigated. Patients with a known systemic disease, using aspirin, low-molecular-weight heparin and steroids were excluded. A total of 359 patients (81 with GDM and 278 controls) were enrolled. The assessed parameters in CBC were hemoglobin, hematocrit, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cells (including neutrophils, lymphocytes, monocytes, eosinophils, basophils), platelets, platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), nucleated red blood cell (NRBC), NRBC percentage, plateletcrit (PCT), platelet large cell ratio (P-LCR), immature granulocytes (IG) and IG percentage. Platelet mass index (PMI), neutrophil-tolymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) were calculated. These parameters were compared between GDM patients and controls. Regression analysis was performed with the parameters that were significantly correlated with GDM. ROC curve analysis was done in order to find cutoff values. Results: RBC, WBC (all subtypes including immature granulocytes), platelet indices including PMI, NLR and PLR were all similar. Only RDW and NRBC were found to be significantly increased in GDM patients and came out to be independent predictors of GDM with maternal age and screening week. Conclusion: These findings suggest that women with GDM may be accompanied with increased RDW and NRBC levels which seem to be independent predictors of this disease and these parameters may be used to monitor and evaluate the development of GDM.

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“…Accordingly, we hypothesize that there is a relationship between platelet indices and PDPH. MPV, which reflects platelet size and production rate in bone marrow, is a commonly used parameter to evaluate platelet activity and function [20,[39][40][41]. MPV has been studied in the context of many pathological conditions, including cardiovascular, respiratory, inflammatory, and neoplastic diseases, and has been reported to be an important marker in some of these diseases [24][25][26][27][42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Can Platelet Count and Mean Platelet Volume be Used as Markers of Postdural Puncture Headache in Obstetric Patients?

Uzundere

Kaçar

Kaya

2020

Pain Research and Management

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Objective. In this study, considering the importance of platelet function in inflammatory processes, we explored whether there are relationships of platelet indices with postdural puncture headache (PDPH) and pain developing after use of spinal needles and whether patient characteristics contribute to the development of PDPH. Methods. This prospective, observational study included 76 patients (Group 1) with PDPH and 93 patients (Group 2) without PDPH. The postoperative hemoglobin, hematocrit, platelet count (PC), and mean platelet volume (MPV) values were recorded, along with age, blood type, Rh factor, gravida, parity, and gestational age. In addition, the time of the onset of pain was recorded in patients who complained of a postspinal headache. Results. Hemoglobin and hematocrit values in Group 1 were significantly lower than in Group 2 (both, p=0.024). The PC of Group 1 was significantly higher than that of Group 2 (p<0.001), whereas the MPV was significantly lower (p<0.001). The area under the curve (AUC) values were significant for hemoglobin, hematocrit, PC, and MPV (p=0.022, p=0.024, p<0.001, and p<0.001, resp.). For MPV, the AUC value was 0.293, sensitivity was 1%, and specificity was 99%. The highest likelihood ratio (LR+) value was 1.22 at a cut-off value of 13.3 fL. For the PC, the AUC value was 0.666, the sensitivity was 9%, and the specificity was 99%, while the highest LR + value was 8.56 at a cut-off value of 352 × 109/L. There was no significant relationship between the parameters examined and the onset of pain. Conclusion. In this study, the PC was higher and MPV was lower in obstetric patients with PDPH compared with the control group. However, we also found that these two values cannot be used as markers of PDPH.

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Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cited by 26 publications

References 42 publications

Mpv for Predicting Gestational Diabetes Mellitus

Mpv for Predicting Gestational Diabetes Mellitus

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Can Platelet Count and Mean Platelet Volume be Used as Markers of Postdural Puncture Headache in Obstetric Patients?

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