Mean platelet volume

Farag, Azza Gaber Antar; Zytoon, Ashraf Anas; Habib, Mona Salah El‐din; Elnaidany, Nada Farag; Ibrahem, Reda Abdel Latif; Salman, Samar; Mahfouz, Reda Z.

doi:10.1097/01.ewx.0000532719.31339.7c

Cited by 8 publications

(9 citation statements)

References 36 publications

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“…In this study, there was no significant difference in MPV before and after treatment, this agrees with a previous study that reported no difference in MPV between psoriasis patients and controls (8) . In contrast to our results, other studies demonstrated that MPV was significantly higher in psoriatic patients than that in controls, and was positively correlated with PASI score (9,10) . Ezgi and colleagues (7) demonstrated that MPV was significantly higher in patients with psoriasis Vulgaris, suggesting that platelets play an important role in the pathogenesis of psoriasis and may help assess treatment outcomes.…”

Section: Discussioncontrasting

confidence: 99%

Mean Platelet Volume in Psoriasis: Is it a New Prognostic Indicator?

Tawfik

Romeia

Youssef

et al. 2022

Suez Canal University Medical Journal

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Background: Psoriasis is a chronic multifactorial inflammatory autoimmune disease. It has significant impacts on health and quality of life. Platelets play a major role in the pathogenesis of psoriasis, and the activated platelets increase the migration of leukocytes to the skin, increasing the release of inflammatory cytokines. Recent studies showed that MPV (mean platelet volume) could be used as an indicator of platelet function and activation. Previous studies assessed only the value of MPV in psoriatic patients without studying its relationship with different treatment modalities. Aim: To study the changes in MPV in psoriasis patients and its association with disease severity after treatment with NB-UVB. Patents and Methods: 25 psoriatic patients were assessed for MPV and psoriasis area and severity index score (PASI) before treatment, during treatment, and after treatment with NBUVB (three times weekly for 3 months). Results: The relation between MPV and PASI was statistically insignificant before and after treatment. The PASI score was significantly decreased after treatment. Conclusion: This study demonstrated an insignificant correlation between MPV levels and PASI score of psoriatic patients before and after NBUVB phototherapy. Further studies on a larger number of patients are needed to assess the relationship between MPV and psoriasis.

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Section: Discussioncontrasting

confidence: 99%

Mean Platelet Volume in Psoriasis: Is it a New Prognostic Indicator?

Tawfik

Romeia

Youssef

et al. 2022

Suez Canal University Medical Journal

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“…The rapidly expanding evidence of research in various populations supports that the value of MPV was significantly increased in patients with psoriasis compared with that of controls [19, 36-45] (Table 1). An elevated MPV level was found in psoriasis as well as psoriatic arthritis [39, 41, 44], and there was also a higher expression of MPV in patients with arthritis [44].…”

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 90%

“…Besides, higher MPV levels were dramatically demonstrated among psoriatic patients with atherosclerosis and metabolic syndrome compared to psoriatic patients without atherosclerotic changes and metabolic syndrome [36, 37, 46]. MPV could be an early predictor to diagnose premature atherosclerosis more accurately and sensitively in psoriasis.…”

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

“…Most studies have shown that elevated MPV values are positively correlated with disease severity measured by the psoriasis area and severity index (PASI) score [36-40, 43-45]. However, the experimental data are rather controversial, and there is no general agreement about the positive relationship between MPV and disease severity.…”

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

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Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

et al. 2020

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Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis and thrombosis, and platelet dysfunction is deeply involved in the pathogenesis of psoriasis. Summary: The aim of this study is to perform a review that expounds abnormal platelet function in psoriasis and explains the important role of platelets in the pathogenic mechanism of psoriasis in order to provide new targets for comprehensive medical treatment.

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“…MPV is significantly increased in patients with psoriasis. [32][33][34][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] Studies have shown a positive relationship between MPV and psoriasis severity expressed by the psoriasis area and severity index (PASI) score. Two recent meta-analyses studied platelet-associated parameters and blood count in patients with psoriasis and healthy controls.…”

Section: Platelets In Psoriasismentioning

confidence: 99%

Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

Péč,

Jurica,

Péčová

et al. 2023

Semin Thromb Hemost

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Platelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune diseases. This review aims to highlight the role of platelets in the pathogenic mechanisms of the most frequent chronic autoimmune inflammatory diseases to identify gaps in current knowledge and to provide potential new targets for medical interventions.

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Mean platelet volume

Cited by 8 publications

References 36 publications

Mean Platelet Volume in Psoriasis: Is it a New Prognostic Indicator?

Mean Platelet Volume in Psoriasis: Is it a New Prognostic Indicator?

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

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