Mean daily intake of N-nitrosodimethylamine from foods and beverages in France in 1987–1992

Biaudet, Hugues; Mavelle, T.; Debry, G

doi:10.1016/0278-6915(94)90039-6

Cited by 47 publications

(19 citation statements)

References 8 publications

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“…So the chances of NDMA reaching human biological system are very high. [19] In the present study, the effect of Operculina turpethum and its isolated Stigma-5,22dien-3-O-β-D-glucopyranoside on the hematological and serological parameters of mice bearing cancer was evaluated.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of operculina turpethum and its isolated stigma-5,22dien-3-o-β-D-glucopyranoside on the hematological parameters of male mice exposed to n-nitrosodimethylamine, a potent carcinogen

Sharma¹,

Singh²

2014

Toxicol Int

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Objectives:Enormous propensity of plants to synthesize a variety of structurally diverse bioactive compounds, has made the plant kingdom a potential source of chemical constituents with various therapeutic values, including antitumor and cytotoxic activities. Blood is a good indicator to determine the physiological and pathological status of man and animal. The objective of the present study is to determine the effect of Operculina turpethum root extract and its isolated glycoside treatment on the hematological parameters in the mice with N-Nitrosodimethylamine (NDMA) induced cancer.Materials and Methods:The body weights of the animals were recorded before and after the experiment. Non-coagulated blood was tested for total erythrocyte count, total leukocyte count, hemoglobin, differential leukocyte count (DLC) and for other blood indices.Results:A significant (P < 0.01), (P < 0.001) recovery of the red blood cell and white blood cell counts, packed cell volume and hemoglobin content in the host after 21 day treatment was shown.Conclusion:These results show that the extract of Operculina turpethum is relatively safe following oral administration and have possible stimulatory effect on red blood cell production and there was dose dependent therapeutic effect.

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Section: Introductionmentioning

confidence: 99%

Ameliorative effects of operculina turpethum and its isolated stigma-5,22dien-3-o-β-D-glucopyranoside on the hematological parameters of male mice exposed to n-nitrosodimethylamine, a potent carcinogen

Sharma¹,

Singh²

2014

Toxicol Int

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“…Main contributions are food products, namely bacon/ham, cheese and poultry. Average concentrations of NDMA are in the order of 1 μg/kg for meat products (Biaudet et al 1994), which can be used to estimate exposure based on consumption. Munoz has summarised reported values from various sources including detailed assessment of food types extensively (Munoz 2005).…”

Section: Exposure To Ndma Through Food Drinks and Smokingmentioning

confidence: 99%

“…8 Table 4 Estimation of daily intake of NDMA in various countries (adapted from (Biaudet et al 1994, Tricker et al 1991 Drinks can contribute significantly to NDMA intake. For example, Gloria et al (Glória et al 1997b) found NDMA in beer at concentrations of 0.05 to 0.55 μg/kg, originating from the fermentation process.…”

Section: Exposure To Ndma Through Food Drinks and Smokingmentioning

confidence: 99%

Chapter 7 Micropollutants in Water Recycling: A Case Study of N-Nitrosodimethylamine (NDMA) Exposure from Water versus Food

Schäfer

Mitch

Walewijk

et al. 2010

Sustainable Water for the Future: Water Recycling Versus Desalination

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One of the most concerning xenobiotics currently under discussion by regulators and treatment experts is N-Nitrosodimethylamine (NDMA). NDMA is a carcinogen known to induce cancer in a variety of animals, causing DNA damage at low doses. Human exposure occurs through cigarettes, food, personal care products and drinking water, in addition to endogenous formation in the stomach.The daily tolerable limit for intake has been identified to be 4.0 -9.3 ng/kg.day (Fitzgerald and Robinson 2007). Water at the WHO proposed guideline value of 100 ng/L would contribute about 2.9 ng/kg.day of this intake, while intake from food varies from 5.7 -44.2 ng/kg.day. Smoking and workplace are additional exposure routes. This outlines that the exposure is often higher than tolerable limits. In the food and drinks industry this has in recent decades resulted in improved manufacturing processes.Awareness of NDMA in drinking water is a relatively recent issue. NDMA stems from precursors in raw water and can be generated during treatment. Generally removal of precursors is more achievable than the removal of NDMA itself. For example, the potent NDMA precursor dimethylamine is rapidly removed in biological pre-treatment, while many other precursor amines are more persistent. These precursor amines include some ion exchange resins and coagulants, used in water treatment processes, which have been shown to generate NDMA during chlorination. Ozonation has also been shown to produce NDMA in treatment. UV oxidation is the preferred method for removal of NDMA in water treatment, although reverse osmosis membranes are possible alternatives if effective retention can be achieved.

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“…Distributions of NDMA concentrations in meat, fish, dairy, cereal and vegetables were based on the results of a French study conducted from 1987 to 1992 (Biaudet et al 1994) and a German study conducted from 1989 to 1990 (Tricker et al 1991). Several studies identified dietary sources of nitrites and nitrates (Walker 1990;NRC 1995).…”

Section: Ndma Concentrations In Foodsmentioning

confidence: 99%

Estimation of the total daily oral intake of NDMA attributable to drinking water

Fristachi

Rice

2007

Journal of Water and Health

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Disinfection with chlorine and chloramine leads to the formation of many disinfection by-products including N-Nitrosodimethylamine (NDMA). Because NDMA is a probable human carcinogen, public health officials are concerned with its occurrence in drinking water. The goal of this study was to estimate NDMA concentrations from exogenous (i.e., drinking water and food) and endogenous (i.e., formed in the human body) sources, calculate average daily doses for ingestion route exposures and estimate the proportional oral intake (POI) of NDMA attributable to the consumption of drinking water relative to other ingestion sources of NDMA. The POI is predicted to be 0.02% relative to exogenous and endogenous NDMA sources combined. When only exogenous sources are considered, the POI was predicted to be 2.7%. The exclusion of endogenously formed NDMA causes the POI to increase dramatically, reflecting its importance as a potentially major source of exposure and uncertainty in the model. Although concentrations of NDMA in foods are small and human exposure to NDMA from foods is quite low, the contribution from food is predicted to be high relative to that of drinking water. The mean concentration of NDMA in drinking water would need to increase from 2.1 £ 10 23 mg/L to 0.10 mg/L, a 47-fold increase, for the POI to reach 1%, relative to all sources of NDMA considered in our model, suggesting that drinking water consumption is most likely a minor source of NDMA exposure.

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Mean daily intake of N-nitrosodimethylamine from foods and beverages in France in 1987–1992

Cited by 47 publications

References 8 publications

Ameliorative effects of operculina turpethum and its isolated stigma-5,22dien-3-o-β-D-glucopyranoside on the hematological parameters of male mice exposed to n-nitrosodimethylamine, a potent carcinogen

Ameliorative effects of operculina turpethum and its isolated stigma-5,22dien-3-o-β-D-glucopyranoside on the hematological parameters of male mice exposed to n-nitrosodimethylamine, a potent carcinogen

Chapter 7 Micropollutants in Water Recycling: A Case Study of N-Nitrosodimethylamine (NDMA) Exposure from Water versus Food

Estimation of the total daily oral intake of NDMA attributable to drinking water

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