Mean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney disease

Solak, Yalçın; Yılmaz, Mahmut İlker; Sağlam, Mutlu; Demirbaş, Şeref; Verim, Samet; Ünal, Hilmi Umut; Gaipov, Abduzhappar; Oğuz, Yusuf; Kayrak, Mehmet; Çağlar, Kayser; Vural, Abdülgaffar; Türk, Süleyman; Covic, Adrian; Kanbay, Mehmet

doi:10.1111/nep.12130

Cited by 53 publications

(47 citation statements)

References 22 publications

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“…Patients with high MCV commonly develop hyperhomocysteinemia [25], which is known to augment cardiovascular risk [26][27][28]. Moreover, high MCV is an independent prognosticator of impaired endothelial function measured via flow-mediated dilatation [8], which may be explained by disrupted erythrocyte antioxidative potential in macrocytes and an associated imbalance in global redox homeostasis of the organism [8]. Finally, macrocytosis may reflect a malnutrition, as associations between high MCV, and lower LDL cholesterol levels and lower BMI were reported [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…High MCV (macrocytosis) is known to be elevated in various conditions, regardless of concomitant anemia [7]. Several studies have addressed associations between high MCV and increased mortality, independently of anemia, in different pathologies, such as chronic kidney disease [8], acute heart failure [9], and in patients after PCI [10]. To the best of our knowledge, a prognostic value of high MCV among patients admitted due to AMI has not yet been analyzed.…”

Section: Introductionmentioning

confidence: 99%

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Could an analysis of mean corpuscular volume help to improve risk stratification in non-anemic patients with acute myocardial infarction?

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Could an analysis of mean corpuscular volume help to improve risk stratification in non-anemic patients with acute myocardial infarction?

et al. 2015

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“…hematological biomarkers, acute mortality, linear and quadratic models, concentration levels, death risk levels (> 95 fL), whereas MCH, MCHC, and PLT have no impact on the excess acute mortality in ED patients. For example, RDW following the adjusted hazard ratios (HRs) for all-cause mortality were strongly associated with an increased risk of death in middle-aged and older (11,827) adults, i.e. for every 1% increment in RDW, all-cause mortality risk increased by 22% (HR = 1.22, 95%CI: 1.15-1.30, P < 0.001) [1].…”

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confidence: 99%

Selected hematological biomarkers to predict acute mortality in emergency department patients: Recent Polish hospital statistics

Brzeźniakiewicz‐Janus

Lancé

Tukiendorf

et al. 2020

Preprint

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Background Complete blood count (CBC): red cell distribution width (RDW), mean platelet volume (MPV), mean corpuscular volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), or platelet (PLT) count are referred as predictors of adverse clinical outcomes in patients. The aim of the research was to identify potential factors of acute mortality in Polish ED patients by using selected hematological biomarkers and routine statistical tools. Methods The study presents statistical results on patients who were recently discharged from inpatient facilities within one month prior to the index emergency department (ED) visit. In total, the analysis comprised 14,904 patients with the first RDW, MPV, MCV, MCH, MCHC, or PLT biomarkers’ measurements recorded in the Emergency Department within the years 2016–2019 with a subsequent one month of all-cause mortality observation. The patients were classified with the codes of the International Statistical Classification of Diseases and Related Health Problems after 10th Revision (ICD10). Results Based on the analysis of RDW, MPV, MCV, MCH, MCHC, and PLT on acute deaths in patients, we establish strong linear and quadratic relationships between the risk factors under study and the clinical response (P < 0.05), however, with different mortality courses and threats. In our statistical analysis, (1) gradient linear relationships were found for RDW and MPV along an entire range of the analyzed biomarkers’ measurements, (2) following the quadratic modeling, an increasing risk of death above 95 fL was determined for MCV, and (3) no relation to excess death in ED patients was calculated for MCH, MCHC and PLT. Conclusion The study shows that there are likely relationships between blood counts and expected patient mortality at some time interval from measurements. Up to 1 month of observation since the first measurement of an hematological biomarker, RDW and MPV stand for a strong relationship with acute mortality of patients, whereas MCV, MCH, MCHC, and PLT give the U-shaped association, RDW and MPV can be established as the stronger predictors of early deaths of patients, MCV only in the highest levels (> 95 fL), whereas MCH, MCHC, and PLT have no impact on the excess acute mortality in ED patients.

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“…32,33 RDW may reflect early signs of anemia and also correlated with inflammatory parameters. 34,35 In this study, RDW and NLR were more reliable predictors of systemic recurrence than for lymphonodal recurrence. Also, low…”

Section: Discussionmentioning

confidence: 54%

“…Low Hb levels leads to reduced tumor tissue oxygenation, impairing chemoradiotherapy sensitivity and reducing the therapeutic effect . RDW may reflect early signs of anemia and also correlated with inflammatory parameters . In this study, RDW and NLR were more reliable predictors of systemic recurrence than for lymphonodal recurrence.…”

Section: Discussionmentioning

confidence: 54%

The value of cellular components of blood in the setting of trimodal therapy for esophageal cancer

Tustumi

Takeda

Viyuela

et al. 2019

Journal of Surgical Oncology

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Background Inflammation status plays an important role in the natural history of malignancy. Consequently, hematological markers of systemic inflammation may predict prognosis in neoplasms. This study evaluated the value of cellular blood components changes during neoadjuvant chemoradiotherapy followed by esophagectomy for cancer in predicting prognosis. Methods A cohort of 149 patients was analyzed. Cellular components of blood were assessed before neoadjuvant therapy (A); before surgery (B); and 3 to 5 months after surgery (C); for the following outcomes: pathological response, overall survival (OS), and disease‐free survival (DFS). Univariate and multivariate Cox regression models were applied to evaluate the independent prognostic significance of blood count variables. Results Low hematocrit (Ht) (C) (HR, 0.85; 95% CI, 0.79‐0.92) and high neutrophil‐to‐lymphocyte ratio (NLR) (C) (HR, 1.07; 95% CI, 1.07‐1.10) were related to poor OS. Low Hb (C) (HR, 0.72; 95% CI, 0.58‐0.88), red cell distribution width (RDW) (C‐A) (HR, 1.16; 95% CI, 1.02‐1.31), and NLR (C‐A) (1.06; 95% CI, 1.03‐1.09) were related to poor DFS. RDW (B‐A) (HR, 1.15; 95% CI, 1.08‐1.22), RDW (C) (HR, 1.12; 95% CI, 1.04‐1.2), NLR (C) (HR, 1.12; 95% CI, 1.08‐1.17) were related to systemic recurrence. Conclusion Variables of routine blood count are easily assessable and their changes throughout trimodal therapy for esophageal carcinoma provide important information for cancer patient's prognosis.

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Mean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney disease

Abstract: This is the first study in the literature showing an independent association of MCV and FMD. Our results also determined MCV as an independent predictor of composite CV events independent of anaemia, inflammation, diabetes and eGFR in patients with CKD.

Cited by 53 publications

References 22 publications

Could an analysis of mean corpuscular volume help to improve risk stratification in non-anemic patients with acute myocardial infarction?

Could an analysis of mean corpuscular volume help to improve risk stratification in non-anemic patients with acute myocardial infarction?

Selected hematological biomarkers to predict acute mortality in emergency department patients: Recent Polish hospital statistics

The value of cellular components of blood in the setting of trimodal therapy for esophageal cancer

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