Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test

Li, Zhanzhan; Zhou, Qin; Li, Yanyan; Yan, Shipeng; Fu, Jun; Huang, Xinqiong; Shen, Liangfang

doi:10.18632/oncotarget.14922

Cited by 16 publications

(21 citation statements)

References 31 publications

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“…specificity, and AUC, a value of 1.0 was considered as the highest diagnostic accuracy and AUC < 0.5 indicated a poor diagnostic accuracy. [17][18][19] The heterogeneity within studies was assessed by using the Q test and I 2 statistic. I 2 > 50% and/or P < 0.05 indicated significant heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

“…We used the bivariate mixed‐effect model to pool the following index and their 95% confidence internals (CIs): sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and symmetric receiver operator characteristic (AUC) . For sensitivity, specificity, and AUC, a value of 1.0 was considered as the highest diagnostic accuracy and AUC < 0.5 indicated a poor diagnostic accuracy . The heterogeneity within studies was assessed by using the Q test and I 2 statistic.…”

Section: Methodsmentioning

confidence: 99%

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Assessment on clinical value of prostate health index in the diagnosis of prostate cancer

Zhang

et al. 2019

Cancer Medicine

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In this study, we performed a comprehensive estimation and assessment for the clinical value of prostate health index (PHI) in diagnosing prostate cancer. Using the bivariate mixed‐effect model, we calculated the following parameters and their 95% confidence internals (CIs), including sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and symmetric receiver operator characteristic. Twenty eligible studies with a total number of 5543 subjects were included in the final analysis. The estimated sensitivity was 0.75 (95% CI: 0.70‐0.79) and the specificity was 0.69 (95% CI: 0.58‐0.83). The pooled area under the curve was 0.78 (95% CI: 0.74‐0.81). The combined positive likelihood ratio was 2.45 (95% CI: 2.19‐2.73) and the negative likelihood ratio was 0.36 (95% CI: 0.31‐0.43). The diagnostic odds ratio was 6.73 (95% CI: 5.38‐8.44). The posttest probability was 40% under the present positive likelihood ratio of 2.45. It seems there was no significant difference between Asian population and Caucasian population population in sensitivity and specificity. But the overlap of AUC 95% CI indicated that the diagnostic accuracy of PHI was slightly higher in the Asian population population setting than that in the Caucasian population population population (0.83 vs 0.76). Similarly, there was also overlap in AUC 95% CI, which suggested that sample size may be one of heterogeneity source. The PHI has a moderate diagnostic accuracy for detecting prostate cancer. The discrimination ability of PHI is slightly prior to free/total prostate‐specific antigen. It seems that ethnicity has an influence on the clinical value of PHI in the diagnostic of prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Assessment on clinical value of prostate health index in the diagnosis of prostate cancer

Zhang

et al. 2019

Cancer Medicine

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“…Firstly, the threshold effect was evaluated by Spearman correlation coefficient, significant value of which means the existence of the threshold effect. [14][15][16] Heterogeneity was evaluated by chi-square and I 2 statistic, with the significance level at P < 0.05 or I 2 > 50%. 17 Sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the 95% confidence intervals (CIs) were pooled using a bivariate random-effect model.…”

Section: Discussionmentioning

confidence: 99%

“…Statistical analyses were performed on Stata 13 (StataCorp LP, College Station, TX, USA), and the quality was assessed on Review Manager 5 (Nordic Cochrane Centre, Cochrane Collaboration, 2014). Firstly, the threshold effect was evaluated by Spearman correlation coefficient, significant value of which means the existence of the threshold effect . Heterogeneity was evaluated by chi‐square and I 2 statistic, with the significance level at P < 0.05 or I 2 > 50% .…”

Section: Methodsmentioning

confidence: 99%

Positron emission tomography/computed tomography outperforms MRI in the diagnosis of local recurrence and residue of nasopharyngeal carcinoma: An update evidence from 44 studies

et al. 2018

Cancer Medicine

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Studies on nasopharyngeal carcinoma (NPC) in five electronic databases were systematically searched online from the inception to June 5, 2018. Quality of the included studies was assessed using the updated Quality Assessment of Diagnostic Accuracy Studies 2. Data of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the 95% confidence intervals were pooled using a bivariate random‐effect model. Forty‐four studies with 61 groups of data and totally 3369 patients were included in the qualitative and quantitative synthesis analysis. The overall estimated sensitivity and specificity of positron emission tomography/computed tomography/magnetic resonance imaging (PET‐CT/MRI) for local recurrent/residual NPC were 0.90 and 0.85, respectively. The pooled area under the curve of (AUC) of PET‐CT/MRI in the summary receiver operator characteristic curve was 0.94. Subgroup analysis showed MRI vs PET‐CT had lower sensitivity (0.83 vs 0.92) and specificity (0.78 vs 0.89). The AUCs of MRI and PET‐CT were 0.87 and 0.96, respectively. No‐cross of 95% CI was found in MRI vs PET/CT (0.87‐0.90 vs 0.94‐0.98). Meta‐regression showed PET/CT vs MRI was a potential source of heterogeneity. PET/CT and MRI both showed quite high overall ability in diagnosing local recurrent/residual NPC, but the subgroup analysis indicated PET‐CT was superior over MRI in diagnosis of local recurrence and residue of NPC after radiotherapy. The examination methods affected the heterogeneity within studies.

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“…The local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC [8,9]. As a complex heterogeneous group, the tumor has extensive information interaction with the surrounding environment [10][11][12]. Most tumor cells can form cell clusters (multicellular spheroids, MCS) under the condition of three-dimensional, its biological characteristics and the responses to the rays and cytotoxic drugs were significantly different from ordinary monolayer culture cells, but was close to cells in the body.…”

Section: Introductionmentioning

confidence: 99%

Role of MAP2K6 in sensitivity to radiotherapy of human nasopharyngeal carcinoma CNE cells

Fu¹,

Li²,

Li³

2018

biomedicalresearch

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Background: Radiation therapy is one of the main treatment of nasopharyngeal carcinoma. This study explored the influence of mitogen-activated protein kinase kinase 6 (MAP2K6) on nasopharyngeal carcinoma radiotherapy sensitivity and its possible mechanism. Methods: Human NPC sensitivity and resistant cell line CNE multicellular spheroids (MCS) were constructed with three dimensional cell culture methods. Cell counting using blood cell counter was employed to detect the radio-sensitivity of CNE MCS before and after blocking MAP2K6 function; the MAP2K6 expression of CNE MCS and cell apoptosis was detected by flow cytometry. Results: The expression of MAP2K6 increased by elevation of irradiation dose.

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Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test

Cited by 16 publications

References 31 publications

Assessment on clinical value of prostate health index in the diagnosis of prostate cancer

Assessment on clinical value of prostate health index in the diagnosis of prostate cancer

Positron emission tomography/computed tomography outperforms MRI in the diagnosis of local recurrence and residue of nasopharyngeal carcinoma: An update evidence from 44 studies

Role of MAP2K6 in sensitivity to radiotherapy of human nasopharyngeal carcinoma CNE cells

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