Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects

Kerins, Carolyn A.; Carlson, David S.; McIntosh, J. E. A.; Bellinger, Larry L.

doi:10.1016/s0091-3057(03)00072-8

Cited by 43 publications

(70 citation statements)

References 30 publications

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“…It has been suggested that food intake could be an important indicator for TMJ inflammation/pain (Harper et al, 2000;Kerins et al, 2003). Our results also showed that food intake decreased with the decreased head withdrawal threshold after induction of TMJ inflammation, further supporting that food intake can be a proper indicator for TMJ inflammation/pain.…”

Section: Food Intake As An Indicator For Tmj Painsupporting

confidence: 77%

“…Food intake is negatively associated with TMJ inflammation/pain and can be used as an indicator for TMJ inflammation/pain (Harper et al, 2000;Kerins et al, 2003). We measured the food intake with minor modifications in that the rats were initially fasted over a period of time and then the amount of food eaten by rats was measured for a limited time.…”

Section: Methodsmentioning

confidence: 99%

“…In our experiments there was a period of time for fasting to cause the rats to become hungry before the measurement of food intake and food eaten during the period of 2 h, which was counted as food intake. Several studies have already demonstrated that food intake in 24 h is not changed, but the duration of the meal is extended in rats with TMJ inflammation (Harper et al, 2000;Kerins et al, 2003). Therefore, our food intake measurement in a limited time period might better reflect the severity of TMJ inflammation and pain.…”

Section: Food Intake As An Indicator For Tmj Painmentioning

confidence: 97%

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17- -Estradiol Enhanced Allodynia of Inflammatory Temporomandibular Joint through Upregulation of Hippocampal TRPV1 in Ovariectomized Rats

Wu¹,

Bi²,

Kou³

et al. 2010

Journal of Neuroscience

105

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Temporomandibular disorders (TMDs) predominantly affect reproductive female patients, with pain the most frequent complaint. Although estrogens are believed to play important roles in TMD pain, the mechanism underlying modulation of TMD pain by estrogens remains largely unknown. Accumulating evidence implies that the hippocampus is involved in sexual dimorphism of pain sensitivity. In this study, we investigated the hippocampal TRPV1 (transient receptor potential vanilloid 1) expression in ovariectomized rats that received 17-␤-estradiol substitution and found that 17-␤-estradiol enhanced the mechanical allodynia of inflamed temporomandibular joint (TMJ) induced by complete Freund's adjuvant. Real-time PCR and immunoblotting demonstrated that TMJ inflammation significantly induced hippocampal TRPV1 expression compared with the control group but failed to induce it in the ovariectomized rats that received no estradiol replacement. In addition, estradiol potentiated TMJ inflammation-induced hippocampal TRPV1 expression in a dose-dependent manner in the ovariectomized rats. In contrast, TRPV1 transcription in amygdala, prefrontal cortex, and thalamus was not affected by TMJ inflammation and estradiol. Immunostaining showed TRPV1 localized in the processes and cytoplasm of pyramidal neurons in CA1-CA3 regions of the hippocampus. Moreover, intrahippocampal injection of TRPV1 antagonists capsazepine and 5Ј-iodoresiniferatoxin into the CA1 region of the hippocampus significantly attenuated allodynia of inflamed TMJ in both nonovariectomized and ovariectomized rats that received estradiol replacement. Our results suggested that hippocampal TRPV1 can modulate central pain processing and estradiol may contribute to the sexual dimorphism of TMD pain sensitivity through upregulation of TRPV1 expression in the hippocampus.

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Section: Food Intake As An Indicator For Tmj Painsupporting

confidence: 77%

Section: Methodsmentioning

confidence: 99%

Section: Food Intake As An Indicator For Tmj Painmentioning

confidence: 97%

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17- -Estradiol Enhanced Allodynia of Inflammatory Temporomandibular Joint through Upregulation of Hippocampal TRPV1 in Ovariectomized Rats

Wu¹,

Bi²,

Kou³

et al. 2010

Journal of Neuroscience

105

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“…To assess welfare, we measured aggression (a common outcome of cage-cleaning in mice as mentioned above) versus 'play', checked for stomach ulceration, and measured chromodacryorrhoea. Chromodacryorrhoea ('red/bloody tears') is a dark red stress-related secretion from the Harderian gland, which appears around the eyes and nose in response to restraint (Harkness & Ridgway 1980), joint pain (Kerins et al 2003), morphine withdrawal (Hepburn et al 1997, Rohde & Basbaum 1998), bright light (Hugo et al 1987, and even mild disturbances (Mason et al 2004). Finally, we examined how the different cleaning rates affected handleability, primarily as a practical consideration.…”

mentioning

confidence: 99%

Long-term effects of cage-cleaning frequency and bedding type on laboratory rat health, welfare, and handleability: a cross-laboratory study

et al. 2006

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SummaryCage-cleaning is necessary for a hygienic environment, but since rats communicate using scent, they might suffer if their cages are cleaned too frequently. Male rats (Sprague-Dawley and Wistar) were kept for five months across four animal units. Their cages were cleaned twice-weekly, weekly, or every two weeks, and contained either aspen woodchips or absorbent paper bedding. Aggression, injuries and general health, weight gain, chromodacryorrhoea (a stress-related Harderian gland secretion), handleability, and lung pathology were monitored, as was in-cage ammonia. Cleaning frequency had no clear impact on rat welfare, although frequent cleaning decreased ammonia concentrations and handleability, and non-aggressive skirmishing was highest in weekly cleaned rats. Surprisingly, bedding type did not affect ammonia, but all ammonia readings were unexpectedly low. However, rats kept on aspen had greater sneezing rates and lung pathology than those on paper bedding, but also had higher body weights. The results raise concerns about aspen bedding, which is relatively inert compared with other wood beddings, but nevertheless more harmful than paper. Animal unit significantly affected eight of the 11 variables tested, having interactive effects on five of them. The study also demonstrates the interactive effects of different animal units, casting doubt on the feasibility of standardization. We explored multiple variables of interest, so all findings require confirmation through further work. Nevertheless, cage-cleaning rates seem to affect socially housed male rats little, while bedding type has important effects on rat health.

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“…It has previously been shown that TMJ-injected CFA can increase IL-1β (Kerins, Carlson, McIntosh & Bellinger, 2003) . Therefore, the cytokines IL-1 were quantitated from this homogenate using ELISA kits according to the manufacturer's directions (R&D Systems, Minneapolis, MN).…”

Section: Cytokine Assaymentioning

confidence: 94%

Cross-Linked Gelatin Microcapsules for Drug Delivery in a Arthritic TMJ

Kramer¹,

Windsor²,

Carson³

et al. 2012

Recent Advances in Arthroplasty

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Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects

Cited by 43 publications

References 30 publications

17- -Estradiol Enhanced Allodynia of Inflammatory Temporomandibular Joint through Upregulation of Hippocampal TRPV1 in Ovariectomized Rats

17- -Estradiol Enhanced Allodynia of Inflammatory Temporomandibular Joint through Upregulation of Hippocampal TRPV1 in Ovariectomized Rats

Long-term effects of cage-cleaning frequency and bedding type on laboratory rat health, welfare, and handleability: a cross-laboratory study

Cross-Linked Gelatin Microcapsules for Drug Delivery in a Arthritic TMJ

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