ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells

Pintova, Sofya; Planutis, Kestutis; Planutiene, Marina; Holcombe, Randall F.

doi:10.21873/anticanres.11495

Cited by 13 publications

(5 citation statements)

References 19 publications

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“…Growing evidence indicates that dietary factors along with alteration in the gutactivator protein 1 microbiota can affect WNT-signaling. Genistein, a soy-derived isoflavone, for which clinical trial phase 1 and 2 has been completed in CRC, inactivates WNT-signaling by GSK3-β targeting [ 202 , 203 , 213 ]. Fisetin (3,7,3′,4′-tetrahydroxyflavone) is a dietary flavonoid that inhibits GSK3-β and activates β-catenin in melanoma cells [ 180 ].…”

Section: Wnt-targeted Therapiesmentioning

confidence: 99%

WNT Signaling in Melanoma

Gajos-Michniewicz

Czyż

2020

IJMS

144

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WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical pathway), the latter can be further divided into WNT/planar cell polarity (PCP) and calcium pathways. WNT ligands are considered as unique directional growth factors that contribute to both cell proliferation and polarity. Origin of cancer can be diverse and therefore tissue-specific differences can be found in WNT-signaling between cancers, including specific mutations contributing to cancer development. This review focuses on the role of the WNT-signaling pathway in melanoma. The current view on the role of WNT-signaling in cancer immunity as well as a short summary of WNT pathway-related drugs under investigation are also provided.

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Section: Wnt-targeted Therapiesmentioning

confidence: 99%

WNT Signaling in Melanoma

Gajos-Michniewicz

Czyż

2020

IJMS

144

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“…It has been shown that genistein can suppress cell growth in colon cancer by decreasing the activity of the PI3K/Akt pathway [ 46 , 47 ]. Genistein has also been implicated in epigenetic regulation of Wnt pathway genes [ 48 ] and reduced colonic tumor growth [ 48 ], as well as inactivating Wnt-signaling by targeting GSK3-β [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…The reference genome and gene annotations of Xenopus laevis were downloaded from Xenbase ( xenbase.org , v10.1). RNA-Seq reads were aligned to the reference genome (v10.1, xenbase.org ) using STAR (2.5.2b, [ 49 ]). The total number of uniquely mapped reads was 13–19 million reads per sample (56 % of sequenced reads).…”

Section: Methods Detailsmentioning

confidence: 99%

Interactions between genistein and Wnt pathway in colon adenocarcinoma and early embryos

Azbazdar,

Sosa,

Monka

et al. 2024

Heliyon

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“…However, it has exhibited contradictory performance in previous studies on colon cancer and the Wnt/β-catenin signaling pathway. Cellular-level experiments using RKO and DLD1 cell lines revealed that genistein alone cannot inhibit Wnt signaling ( 55 ), whereas another report demonstrated that genistein, as an inhibitor of the Wnt/β-catenin signaling pathway, can prevent the development of early colon cancer in animals ( 56 ).…”

Section: Wnt/β-catenin Signaling Pathwaymentioning

confidence: 99%

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways

et al. 2022

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Colorectal cancer (CRC) is a common type of malignant digestive tract tumor with a high incidence rate worldwide. Currently, the clinical treatment of CRC predominantly include surgical resection, postoperative chemotherapy, and radiotherapy. However, these treatments contain severe limitations such as drug side effects, the risk of recurrence and drug resistance. Some natural compounds found in plants, fungi, marine animals, and bacteria have been shown to inhibit the occurrence and development of CRC. Although the explicit molecular mechanisms underlying the therapeutic effects of these compounds on CRC are not clear, classical signaling transduction pathways such as NF-kB and Wnt/β-catenin are extensively regulated. In this review, we have summarized the specific mechanisms regulating the inhibition and development of CRC by various types of natural compounds through nine signaling pathways, and explored the potential therapeutic values of these natural compounds in the clinical treatment of CRC.

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ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells

Abstract: ME-143 alone and in combination with 5FU and oxaliplatin effectively inhibits the WNT/β-catenin pathway in colorectal cancer cells of diverse genetic background. β-Catenin is directly involved in the mechanism of inhibition, and clinical studies are warranted.

Cited by 13 publications

References 19 publications

WNT Signaling in Melanoma

WNT Signaling in Melanoma

Interactions between genistein and Wnt pathway in colon adenocarcinoma and early embryos

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways

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