MDSC; the Most Important Cell You Have Never Heard Of

Tesi, Raymond J.

doi:10.1016/j.tips.2018.10.008

Cited by 203 publications

(156 citation statements)

References 11 publications

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“…Another immunosuppressive effect is mediated by IL-6 secreted from tumor cells, CAFs, and other tumor stromal cells which leads to MDSC recruitment to the tumor microenvironment [89,90]. Importantly, accumulation of MDSCs promotes and fuels chronic inflammation and immunosuppression through promotion of Treg and CAF differentiation and by their differentiation into TAMs [91].…”

Section: Cytokines In the Tumor Microenvironment And Their Effects Onmentioning

confidence: 99%

“…More recently, the role of autophagy in EMT has begun to be established, and controversies exist in the literature regarding the role of autophagy inhibition on EMT; while several studies implicate autophagy in the promotion of EMT, [92]. The immunological profile of cancer-related chronic inflammation thus includes both inflammatory and immunosuppressive cytokines such as IL-1β, IL-6, TGFβ, IL-10, and TNF [91], and their effects primarily induce the activation and maintenance of the JAK2/STAT3, RAS/MAPKs, NF-κB, Wnt, and PI3K/Akt pathways [93][94][95][96][97]. High levels of these cytokines have been found in serum from patients and mouse models from different types of cancers such as breast [98][99][100][101][102][103], colorectal [104], NSCLC [105,106] and head and neck cancer [107][108][109], ovarian cancer, and several hematological malignancies [100], and their increase has been found to correlate with malignancy and a bad prognosis.…”

Section: Autophagy and Its Effects On Epithelial To Mesenchymal Transmentioning

confidence: 99%

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Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive

Rojas-Sánchez

Cotzomi-Ortega

Pazos-Salazar

et al. 2019

Biology

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The manipulation of autophagy for cancer therapy has gained recent interest in clinical settings. Although inhibition of autophagy is currently being used in clinical trials for the treatment of several malignancies, autophagy has been shown to have diverse implications for normal cell homeostasis, cancer cell survival, and signaling to cells in the tumor microenvironment. Among these implications and of relevance for cancer therapy, the autophagic process is known to be involved in the regulation of protein secretion, in tumor cell immunogenicity, and in the regulation of epithelial-to-mesenchymal transition (EMT), a critical step in the process of cancer cell invasion. In this work, we have reviewed recent evidence linking autophagy to the regulation of EMT in cancer and normal epithelial cells, and have discussed important implications for the manipulation of autophagy during cancer therapy.

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Section: Cytokines In the Tumor Microenvironment And Their Effects Onmentioning

confidence: 99%

Section: Autophagy and Its Effects On Epithelial To Mesenchymal Transmentioning

confidence: 99%

Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive

Rojas-Sánchez

Cotzomi-Ortega

Pazos-Salazar

et al. 2019

Biology

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“…The MDSCs are one of the cornerstones of the immunosuppressive shield and prevent the cancer from the patient’s immune system and immunotherapy. They are even vividly called the “queen bee” in the TIME [ 110 ]. As early as the late 1990s, it was found that a class of immune suppressive myeloid cells (CD11b + Gr-1 + ) in spleens of mice, and the phenotypically similar but functionally different from neutrophils and monocytes [ 111 , 112 ].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Zhang

Liu

Liao

2020

J Exp Clin Cancer Res

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Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.

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“…The differentiation of M-MDSCs into macrophages and DCs is influenced by the tumor microenvironment (TME) [ 4 , 5 ]. Considerable evidence shows that MDSCs negatively regulate the immune response in cancer [ 6 , 7 ] and other diseases such as aging [ 8 ] and inflammation [ 9 ]. MDSCs can play an immunosuppressive role through a variety of pathways and mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Connections between Metabolism and Epigenetic Modification in MDSCs

Dai

Wang

et al. 2020

IJMS

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Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells in the tumor microenvironment (TME). During the differentiation and development of MDSCs from myeloid progenitor cells, their functions are also affected by a series of regulatory factors in the TME, such as metabolic reprogramming, epigenetic modification, and cell signaling pathways. Additionally, there is a crosstalk between these regulatory factors. This review mainly introduces the metabolism (especially glucose metabolism) and significant epigenetic modification of MDSCs in the TME, and briefly introduces the connections between metabolism and epigenetic modification in MDSCs, in order to determine the further impact on the immunosuppressive effect of MDSCs, so as to serve as a more effective target for tumor therapy.

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MDSC; the Most Important Cell You Have Never Heard Of

Cited by 203 publications

References 11 publications

Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive

Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Connections between Metabolism and Epigenetic Modification in MDSCs

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