MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors

Burballa, Carla; Crespo, Marta; Redondo-Pachón, Dolores; Pérez‐Sáez, María José; Mir, Marisa; Arias-Cabrales, Carlos; Francés, Albert; Fumadó, Lluís; Cecchini, L.; Pascual, Julio

doi:10.1016/j.nefroe.2017.02.012

Cited by 16 publications

(16 citation statements)

References 17 publications

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“…As reported in previous studies, a positive correlation was also found between total kidney volume and baseline eGFR 16,17 . In addition, similar positive correlation was observed between total kidney mGFR and baseline eGFR, in agreement with the results obtained by Burballa et al 18 . Total kidney volume also signi cantly correlated with total kidney mGFR similar to the report by Halleck et al 13 .…”

Section: Discussionsupporting

confidence: 93%

Comparison of CT Volumetry versus Nuclear Renography for Predicting Remaining Kidney Function After Uninephrectomy in Living Kidney Donors

Eum

Lee

et al. 2021

Preprint

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Computed tomography (CT) and nuclear renography are used to determine kidney procurement in living kidney donors (LKDs). The present study investigated which modality better predicts kidney function after donation. This study included 835 LKDs and they were divided into two subgroups based on whether the left-right dominance of kidney volume was concordant with kidney function (concordant group) or not (discordant group). The predictive value for post-donation kidney function between the two imaging modalities was compared at 1 month, 6 months, and > 1 year in total cohort, concordant, and discordant groups. Split kidney function (SKF) measured by both modalities showed significant correlation with each other at baseline. SKFs of remaining kidney measured using both modalities before donation showed significant correlation with eGFR (estimated glomerular filtration rate) after donation in the total cohort group and two subgroups, respectively. CT volumetry was superior to nuclear renography for predicting post-donation kidney function in the total cohort group and both subgroups. In the discordant subgroup, a higher tendency of kidney function recovery was observed when kidney procurement was determined based on CT volumetry. In conclusion, CT volumetry is preferred when determining procurement strategy especially when discordance is found between the two imaging modalities.

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Section: Discussionsupporting

confidence: 93%

Comparison of CT Volumetry versus Nuclear Renography for Predicting Remaining Kidney Function After Uninephrectomy in Living Kidney Donors

Eum

Lee

et al. 2021

Preprint

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“…The most recent international guideline on living kidney donor evaluation and care recommends using serum creatinine‐based estimating equations and then to “confirm” GFR via direct measurement techniques, creatinine clearance, combined serum creatinine‐cystatin C equations, or simply repeating serum creatinine‐based GFR estimation . We used the CKD‐EPI equation, which may underestimate measured GFR but has been shown to be more accurate than the MDRD equation in living kidney donors . In an earlier study that included much higher proportions of racial and ethnic minorities than our cohort, however, MDRD was found to perform better than CKD‐EPI .…”

Section: Discussionmentioning

confidence: 92%

Baseline living‐donor kidney volume and function associate with 1‐year post‐nephrectomy kidney function

Hall

Shaaban

Wei

et al. 2019

Clinical Transplantation

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Living donors may develop kidney dysfunction more often than equally healthy populations. The purpose of this study was to determine whether computed tomography‐assessed remaining kidney volume indexed to body surface area (RKV/BSA) was associated with 1‐year post‐nephrectomy renal function independent of baseline renal function. Using multivariable regression, we modeled 1‐year estimated glomerular filtration rate (eGFR) and eGFR <60 mL /min/1.73 m2 and considered pre‐determined baseline eGFR subgroups in 151 consecutive donors. Mean ± SD baseline age, eGFR, RKV, BSA, and RKV/BSA were 38 ± 11 years, 97 ± 16 mL/min/1.73 m2, 153 ± 29 mL, 1.9 ± 0.2 m2, and 80.0 ± 12.8 ml/m2, respectively; 50% were female and 94% were white. Mean baseline eGFR was greater with increasing RKV/BSA tertiles (92 ± 14, 97 ± 16, 107 ± 16 mL/min/1.73 m2; P < 0.001). Post‐nephrectomy eGFR remained separated by RKV/BSA tertiles. At baseline, each SD greater RKV/BSA and eGFR was independently associated with higher adjusted 1‐year eGFR by 2.4 and 9.2 mL/min/1.73 m2. Each SD greater age associated with 2.2 mL/min/1.73 m2 lower adjusted 1‐year eGFR. Adjusted odds of 1‐year eGFR <60 increased significantly for donors with RKV/BSA <80 mL/m2. With baseline eGFR <90, probability of 1‐year eGFR <60 increased to >80% with decreasing RKV/BSA values below 80 mL/m2. Those with baseline eGFR >100 rarely developed 1‐year eGFR <60 if RKV/BSA remained >60 mL/m2. RKV/BSA independently associated with 1‐year eGFR <60, especially with lower baseline eGFRs. Additional studies should evaluate the predictive utility of this measure and its potential role in donor evaluations and informed consent.

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“…Murata et al (15) reported that the creatinine-based eGFR/CKD-EPI demonstrated less bias than the eGFR/ MDRD in potential LKT donors (−8% vs. −18%). Burballa et al (16) and Gaillard et al (17) compared the values of the creatinine-based eGFR/CKD-EPI, eGFR/MDRD, and mGFR with isotopes in preoperative LKT donors and concluded that the eGFR/CKD-EPI correlated better with mGFR than did the eGFR/MDRD. Horio et al (18) compared the accuracy of the eGFR/Jm-CKD-EPI and eGFR/ Jm-MDRD with the measured inulin GFR in a health checkup population in Japan.…”

Section: Discussionmentioning

confidence: 99%

The Modified Chronic Kidney Disease Epidemiology Collaboration Equation for the Estimated Glomerular Filtration Rate Is Better Associated with Comorbidities than Other Equations in Living Kidney Donors in Japan

et al. 2021

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Objective We studied three types of estimated glomerular filtration rate (eGFR) equations and evaluated which type was strongly associated with comorbidities in living kidney transplantation (LKT) donors. Methods We compared the Japanese modified estimated glomerular filtration (eGFR), Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration equations (Jm-eGFR, Jm-MDRD, and Jm-CKD-EPI, respectively) for Japanese LKT donors with respect to their relationships with obesity, hypertension, diabetes, cardiovascular disease, and stroke. Results Of the 8,176 enrolled Japanese LKT donors, the eGFR calculated using Jm-CKD-EPI (eGFR/Jm-CKD-EPI) detected significant differences in 4 of 5 comorbidities between the comorbidity-positive and comorbidity-negative groups, whereas the eGFR calculated using Jm-MDRD (eGFR/Jm-MDRD) and Jm-eGFR (eGFR/Jm-eGFR) detected only 3 and 1 comorbidities, respectively. The area under the receiver operating characteristic curve of Jm-CKD-EPI was larger than those of Jm-eGFR and Jm-MDRD for all five comorbidities. Conclusion We found that the eGFR/Jm-CKD-EPI correlated better with comorbidities than the eGFR/Jm-eGFR and eGFR/Jm-MDRD in Japanese LKT donors. We recommend using the eGFR/Jm-CKD-EPI for the initial assessment of the renal function in LKT donor candidates when evaluating the presence of associated comorbidities.

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MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors

Cited by 16 publications

References 17 publications

Comparison of CT Volumetry versus Nuclear Renography for Predicting Remaining Kidney Function After Uninephrectomy in Living Kidney Donors

Comparison of CT Volumetry versus Nuclear Renography for Predicting Remaining Kidney Function After Uninephrectomy in Living Kidney Donors

Baseline living‐donor kidney volume and function associate with 1‐year post‐nephrectomy kidney function

The Modified Chronic Kidney Disease Epidemiology Collaboration Equation for the Estimated Glomerular Filtration Rate Is Better Associated with Comorbidities than Other Equations in Living Kidney Donors in Japan

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