MDRD equation estimates of glomerular filtration rate in potential living kidney donors and renal transplant recipients with impaired graft function

Stoves, John; Lindley, Elizabeth; Barnfield, Mark C.; Burniston, Maria; Newstead, Charles G.

doi:10.1093/ndt/17.11.2036

Cited by 61 publications

(46 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macroalbuminuria was defined as an ACR of >25 mg/mmol for men and >28 mg/mmol for women, with an AER of >300 mg/day. GFR was assessed using the Modification of Diet in Renal Disease (MDRD) formula (31). Hypertension was defined as a systolic pressure of ≥140 mmHg, and/or a diastolic pressure of ≥90 mmHg.…”

Section: Methodsmentioning

confidence: 99%

Decreased expression of circulating microRNA-126 in patients with type 2 diabetic nephropathy: A potential blood-based biomarker

Al‐Κafaji

Al‐Mahroos

Al‐Muhtaresh

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Circulating microRNAs (miRNAs) have been proposed as promising biomarkers for multiple diseases. miR-126 is reported to be associated with type 2 diabetes mellitus (T2D), diabetic nephropathy (DN) and end stage renal disease. The aim of this study was to investigate the expression of circulating miR-126 and to assess its potential as a blood-based biomarker for DN in T2D patients. In 52 patients with T2D without history of DN (with noromoalbuminuria), 50 patients with T2D and DN (29 with microalbuminuria and 21 with macroalbuminuria), and 50 non-diabetic healthy controls, the expression of circulating miR-126 in peripheral whole blood was evaluated by quantitative polymerase chain reaction. The expression levels of circulating miR-126 were significantly decreased in T2D patients and further decreased in DN patients compared with those in the controls. Multivariate logistic regression analysis confirmed the independent association of lower miR-126 levels with T2D [adjusted odds ratio (OR), 0.797; 95% confidence interval (CI), 0.613-0.960] and DN (adjusted OR, 0.513; 95% CI, 0.371-0.708). miR-126 levels were associated with the degree of albuminuria and showed significantly low expression in DN patients with microalbuminuria (adjusted OR, 0.781; 95% CI; 0.698-0.952) and further lower expression in DN patients with macroalbuminuria (adjusted OR, 0.433; 95% CI, 0.299-0.701), respectively compared with T2D patients with normoalbuminuria. miR-126 levels negatively correlated with albuminuria positively with glomerular filtration rate (P<0.05), and in addition, negatively correlated with fasting glucose, glycated hemoglobin, triglyceride and LDL (P<0.05). Stepwise multiple regression analysis identified albuminuria as a significant predictor of miR-126 (P<0.001). miR-126 in peripheral blood yielded area under the receiver operating characteristic curves of 0.854 (95% CI, 0.779-0.929) and 0.959 (95% CI, 0.916-1.000) in the differentiation of DN patients from T2D patients and DN patients from non-diabetic controls respectively. These data suggest that decreased expression of circulating miR-126 is associated with the development of DN in T2D patients, and may be a promising blood-based biomarker for DN risk estimation.

show abstract

Section: Methodsmentioning

confidence: 99%

Decreased expression of circulating microRNA-126 in patients with type 2 diabetic nephropathy: A potential blood-based biomarker

Al‐Κafaji

Al‐Mahroos

Al‐Muhtaresh

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Kidney function was expressed as GFR, estimated with an equation derived from the Modification of Diet in Renal Disease (MDRD) Study, which includes age, gender, race and serum creatinine (17,18), and has been validated for use in the kidney transplant population (19,20). Serum creatinine levels at T-NEMC were calibrated to Cleveland Clinic levels (where serum creatinine used in the development of the MDRD equation was measured) by subtracting 0.2 mg/dL, the mean difference between the values obtained at T-NEMC and the Cleveland Clinic labs.…”

Section: Data Categorization and Definitionsmentioning

confidence: 99%

Anemia: A Continuing Problem Following Kidney Transplantation

Mix¹,

Kazmi²,

Khan³

et al. 2003

American Journal of Transplantation

156

115

View full text Add to dashboard Cite

Cardiovascular disease is a leading cause of death among kidney transplant recipients. Anemia, a risk factor for cardiovascular complications among patients with chronic kidney disease, has not been well characterized in kidney transplant recipients. We performed a retrospective cohort study of the prevalence of and factors associated with anemia among 240 patients who underwent kidney transplantation at our institution. The mean hematocrit (Hct) rose from 33% at 1 month after transplantation to 40% at 12 months after transplantation. The proportion of patients with Hct < 36% was 76% at transplantation and 21% and 36%, 1 year and 4 years after transplantation, respectively. Six months after transplantation, women had higher likelihood (OR = = 3.61) of Hct < 36%, while higher Hct at 3 months (OR = = 0.67 for 1% higher Hct) and diabetes (OR = = 0.14) were associated with a lower likelihood of Hct < 36%. Similar associations were seen 12 months after transplantation. Even among patients with Hct < 30%, only 36% had iron studies, 46% received iron supplementation and 40% received recombinant human erythropoietin. Awareness of factors associated with a lower Hct may prompt better anemia screening and management, potentially improving cardiovascular outcomes among kidney transplant recipients.

show abstract

“…However, graft function in these transplant recipients was evaluated by serum creatinine measurement and endogenous creatinine clearance, methods known as not very accurate in estimating glomerular filtration 23 . Poorer graft function may have affected serum Hcy levels, as suggested by regression analysis results.…”

Section: Discussionmentioning

confidence: 99%

Avaliação dos níveis séricos de homocisteína em transplantados renais com e sem hipercolesterolemia

Piovesan¹,

Veronese²,

Santos³

et al. 2007

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

MDRD equation estimates of glomerular filtration rate in potential living kidney donors and renal transplant recipients with impaired graft function

Cited by 61 publications

References 4 publications

Decreased expression of circulating microRNA-126 in patients with type 2 diabetic nephropathy: A potential blood-based biomarker

Decreased expression of circulating microRNA-126 in patients with type 2 diabetic nephropathy: A potential blood-based biomarker

Anemia: A Continuing Problem Following Kidney Transplantation

Avaliação dos níveis séricos de homocisteína em transplantados renais com e sem hipercolesterolemia

Contact Info

Product

Resources

About