MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer

Komoto, Chiho; Nakamura, Tsutomu; Sakaeda, Toshiyuki; Kroetz, Deanna L.; Yamada, Tetsuya; Omatsu, H.; Koyama, Tatsuya; Okamura, Noboru; Miki, Ikuya; Tamura, Takao; Aoyama, Nobuo; Kasuga, Masato; Okumura, Katsuhiko

doi:10.2133/dmpk.21.126

Cited by 85 publications

(71 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their frequencies were similar to what we found in a previous study of healthy subjects (Komoto et al, 2006). In the postmenstrual phase, the mean serum cortisol level in subjects with 3435CT and 3435TT genotypes was 7.6 ± 3.4 µg/dL, significantly lower than in those with 3435CC (Table 2), whereas the opposite tendency was observed in serum aldosterone levels (Table 2).…”

Section: Effects Of Abcb1 Polymorphisms On Serum Hormone Levels Durinsupporting

confidence: 89%

See 1 more Smart Citation

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles

Nakamura¹,

Okamura²,

Yagi³

et al. 2009

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle was divided into three phases: premenstrual phase (14 days preceding the onset of menstruation, N = 22; menstrual phase, N = 11, and postmenstrual phase, N = 18). ABCB1 -129T>C, 1236C>T, 2677G>A/T, and 3435C>T genotypes were determined. Serum levels of cortisol, aldosterone, estradiol, progesterone, and testosterone were measured. The serum levels of estradiol in the pre-and post- menstrual phases and of progesterone in the premenstrual phase were significantly increased when compared to their serum levels in the menstrual phase (P < 0.005). In the postmenstrual phase, the mean serum cortisol level in subjects with the 3435CT and 3435TT genotype was 7.6 ± 3.4 µg/dL (mean ± SD, N = 7), which was significantly lower than in women with the 3435CC genotype (9.9 ± 1.8 µg/dL, N = 11) (P = 0.037). The opposite effect was observed in the serum aldosterone level during the postmenstrual phase (97.2 ± 23.4 and 141.2 ± 48.5 pg/mL for 3435CC and 3435CT + 3435TT, respectively; P = 0.041). These findings suggest that ABCB1 3435C>T genotype can influence serum levels of cortisol and aldosterone during the postmenstrual phase of the normal menstrual cycle.

show abstract

Section: Effects Of Abcb1 Polymorphisms On Serum Hormone Levels Durinsupporting

confidence: 89%

“…The genotypes of ABCB1 -129T>C (rs3213619), 1236C>T (rs1128503), 2677G>A/T (rs2032582), and 3435C>T (rs1045642) polymorphisms were determined using the TaqMan ® MGB probe and primer, as previously described (Komoto et al, 2006).…”

Section: Genotyping Of Abcb1 Polymorphismsmentioning

confidence: 99%

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles

Nakamura¹,

Okamura²,

Yagi³

et al. 2009

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…The absence of this allele might have been result of small population size of study group. The 2677A allele is shows higher frequency in East Asia population such as Chinese [23], Japanese [33] and Korean population [34]. As the frequency of mutant A allele in European population is very low (1-3%), in our discussion the A allele was pulled with mutant T allele in "W" allele ( Table 4).…”

Section: Discussionmentioning

confidence: 61%

Genotype Variability and Haplotype Profile of Abcb1 (Mdr1) Gene Polymorphisms in Macedonian Population

Naumovska

Nestorovska

Sterjev

et al. 2014

Prilozi

View full text Add to dashboard Cite

The aim of this study was to evaluate the most common ABCB1 (MDR1, P-glycoprotein) polymorphisms in the population of R. Macedonia and compare the allele and haplotype frequencies with the global geographic data reported from different ethnic populations. The total of 107 healthy Macedonian individuals from the general population was included. Genotypes for the ABCB1 for three polymorphisms C1236T [rs1128503], G2677A/T [rs2032582] and C3435T [rs1045642] were analyzed by Real-Time PCR. Obtained allele frequencies for these three SNPs were similar to those observed in other European Caucasians. The detected genotype frequencies were 33.6% for 1236CC, 44.9% for 1236CT and 21.5% for 1236TT in exon 12; 32.7%, 44.9% and 22.4% for 2677GG, 2677GT and 2677GT consecutively in exon 21; and 25.2% for 3435CC, 52.3% for 3435CT and 22.5% for 3435TT in exon 26.Strong LD was observed in our study among all = 0.859, r 2 = 0.711). Eight different haplotypes were identified and the most prominent was the CGC haplotype (45.3%). Our study was the first to have documented the distribution of ABCB1 alleles, genotypes and haplotypes in the population of R. Macedonia. The obtained results can help in the prediction of different response to the drugs that are P-glycoprotein substrates. Additionally, in the era of individualized medicine the determination of the P-glycoprotein genotype might be a good predictive marker for determination of the subpopulations with higher risk to certain diseases.

show abstract

“…Since concentrations of P-gp determine the extent of drug absorption, significant impact of this SNP on bioavailability of drugs is well documented (Maeda and Sugiyama 2008;Kuypers et al 2008;Zhou et al 2008;Hoffmeyer et al 2000). The CC genotype of C3435T is more common in West Africans, African Americans, Japanese and Chinese than in White Americans (Zhang et al 2008;Komoto et al 2006). Accordingly, the clinical use of drugs that are P-gp substrates in African populations may be modified (Chelule et al 2003;Lewis et al 2007;Schaeffeler et al 2001).…”

Section: Discussionmentioning

confidence: 99%

The role of Multidrug Resistance-1 (MDR1) variants in response to atorvastatin among Jordanians

et al. 2014

View full text Add to dashboard Cite

The MDR1 gene encodes for P-glycoprotein (P-gp), which is an efflux transporter at the cell membrane. The P-gp has wide substrate specificity for multiple medications including the lipid lowering drug, atorvastatin. In this study, we investigated the possible association between three common MDR1 gene polymorphisms (G2677T, C3435T, and C1236T), and the lipid lowering effect of atorvastatin among Jordanians. Lipid and lipoproteins were measured in blood samples collected from patients (n = 201) at baseline and during atorvastatin treatment. MDR1 polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Both the TT genotype of G2677T and the TT genotype of the C3435T polymorphisms were associated with lower levels of low-density lipoproteins after atorvastatin treatment. However, the effects of atorvastatin on the levels of total cholesterol, triglycerides, and high-density lipoprotein, were not correlated with any of the genotypes in both polymorphisms. Finally, the C1236T polymorphism was not associated with the lipid lowering effect of atorvastatin. In conclusion, the MDR1 gene polymorphisms G2677T, and C3435T, but not C1236T were associated with the lipid lowering effect of atorvastatin among Jordanians.

show abstract

MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer

Cited by 85 publications

References 31 publications

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles

Genotype Variability and Haplotype Profile of Abcb1 (Mdr1) Gene Polymorphisms in Macedonian Population

The role of Multidrug Resistance-1 (MDR1) variants in response to atorvastatin among Jordanians

Contact Info

Product

Resources

About