MDR ST2179-CTX-M-15 <i>Escherichia coli</i> co-producing RmtD and AAC(6′)-Ib-cr in a horse with extraintestinal infection, Brazil

Leigue, Lucianne; Warth, José Francisco Ghignatti; Melo, Luana C.; Silva, Ketrin C.; Moura, Rodrigo Assunção; Barbato, Leandro; Silva, Lais C; Santos, Ana Maria Ribeiro dos; Silva, Rosa Maria; Lincopán, Nilton

doi:10.1093/jac/dku520

Cited by 15 publications

(10 citation statements)

References 12 publications

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“…The RmtD variant has been found less frequently. Other than the report from Yang et al (123), another recent report has been published from Brazil, on one E. coli isolate from a diseased horse producing RmtD and harboring the bla CTX-M-15 and aac(6′)-Ib-cr genes (125). The RmtE methylase was reported for the first time from commensal E. coli isolates from healthy calves in the United States (126).…”

Section: Resistance To Aminoglycosides By Target Modificationsmentioning

confidence: 97%

Antimicrobial Resistance inEscherichia coli

Poirel

Madec

Lupo

et al. 2018

Antimicrobial Resistance in Bacteria From Livestock and Companion Animals

107

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Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic mechanisms in E. coli correspond to the acquisition of genes coding for extended-spectrum β-lactamases (conferring resistance to broad-spectrum cephalosporins), carbapenemases (conferring resistance to carbapenems), 16S rRNA methylases (conferring pan-resistance to aminoglycosides), plasmid-mediated quinolone resistance (PMQR) genes (conferring resistance to [fluoro]quinolones), and mcr genes (conferring resistance to polymyxins). Although the spread of carbapenemase genes has been mainly recognized in the human sector but poorly recognized in animals, colistin resistance in E. coli seems rather to be related to the use of colistin in veterinary medicine on a global scale. For the other resistance traits, their cross-transfer between the human and animal sectors still remains controversial even though genomic investigations indicate that extended-spectrum β-lactamase producers encountered in animals are distinct from those affecting humans. In addition, E. coli of animal origin often also show resistances to other-mostly older-antimicrobial agents, including tetracyclines, phenicols, sulfonamides, trimethoprim, and fosfomycin. Plasmids, especially multiresistance plasmids, but also other mobile genetic elements, such as transposons and gene cassettes in class 1 and class 2 integrons, seem to play a major role in the dissemination of resistance genes. Of note, coselection and persistence of resistances to critically important antimicrobial agents in human medicine also occurs through the massive use of antimicrobial agents in veterinary medicine, such as tetracyclines or sulfonamides, as long as all those determinants are located on the same genetic elements.

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Section: Resistance To Aminoglycosides By Target Modificationsmentioning

confidence: 97%

Antimicrobial Resistance inEscherichia coli

Poirel

Madec

Lupo

et al. 2018

Antimicrobial Resistance in Bacteria From Livestock and Companion Animals

107

View full text Add to dashboard Cite

show abstract

“…The RmtD variant has been found less frequently. Other than the report from Yang et al (123), another recent report has been published from Brazil, on one E. coli isolate from a diseased horse producing RmtD and harboring the bla CTX-M- 15 and aac(6′)-Ib-cr genes (125). The RmtE methylase was reported for the first time from commensal E. coli isolates from healthy calves in the United States (126).…”

Section: Resistance To Aminoglycosides By Target Modificationsmentioning

confidence: 98%

Antimicrobial Resistance inEscherichia coli

et al. 2018

View full text Add to dashboard Cite

Multidrug resistance in has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic mechanisms in correspond to the acquisition of genes coding for extended-spectrum β-lactamases (conferring resistance to broad-spectrum cephalosporins), carbapenemases (conferring resistance to carbapenems), 16S rRNA methylases (conferring pan-resistance to aminoglycosides), plasmid-mediated quinolone resistance (PMQR) genes (conferring resistance to [fluoro]quinolones), and genes (conferring resistance to polymyxins). Although the spread of carbapenemase genes has been mainly recognized in the human sector but poorly recognized in animals, colistin resistance in seems rather to be related to the use of colistin in veterinary medicine on a global scale. For the other resistance traits, their cross-transfer between the human and animal sectors still remains controversial even though genomic investigations indicate that extended-spectrum β-lactamase producers encountered in animals are distinct from those affecting humans. In addition, of animal origin often also show resistances to other-mostly older-antimicrobial agents, including tetracyclines, phenicols, sulfonamides, trimethoprim, and fosfomycin. Plasmids, especially multiresistance plasmids, but also other mobile genetic elements, such as transposons and gene cassettes in class 1 and class 2 integrons, seem to play a major role in the dissemination of resistance genes. Of note, coselection and persistence of resistances to critically important antimicrobial agents in human medicine also occurs through the massive use of antimicrobial agents in veterinary medicine, such as tetracyclines or sulfonamides, as long as all those determinants are located on the same genetic elements.

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“…This data seems to rule out the possibility that the MDR- E. coli was acquired in the hospital. Of note, a ST2179 E. coli isolate with multi-drug resistance was recently found to claim for extra-intestinal infections in horses in Brazil [24]. Therefore, it seems likely that a possible transmission route for the zoonotic agent ST2179 is present between animals and humans.…”

mentioning

confidence: 99%