MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Sex as decisive variable in lymphoid neoplasms—an update

“… 21 Studies on gene variants or single nucleotide polymorphisms (SNPs) for various genes showed variable associations of gene mutations with the sex of patients and did not find sex-specific functional consequences on response or survival. 22 , 23 , 24 , 25 , 26 Most often, sex-specific disparities are found and reported for the mutational status of the immunoglobulin heavy chain variable region (IgHV) gene. Sex was differently distributed between the mutated (M) and unmutated (UM) subgroups, with men more likely showing UM IgHV ( P = 0.009), in addition to having a higher prevalence in the UM stereotyped BCR subsets (M : F between 1 and 4.4, P = 0.001, compared with 0.8 to 2.0 for the M stereotyped BCR subsets, P = 0.03).…”