MDM2‐Associated Clusterization‐Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer

Liu, Pai; Fu, Weiqiang; Verwilst, Peter; Won, Miae; Shin, Jin Woo; Cai, Zhengxu; Tong, Bin; Shi, Jianbing; Dong, Yuping; Kim, Jong Seung

doi:10.1002/anie.201916524

Cited by 46 publications

(54 citation statements)

References 28 publications

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“…Furthermore, Dong and his co‐workers further developed a facile multicomponent spiropolymerization route to construct heteroatom‐rich spiropolymers with clusteroluminescence (Figure 8C). [ 49 ] This one‐step MCP enjoys the superiorities of no catalyst, simple operation, high atom utilization, and handy monomers, which is perfectly in line with the concept for “green chemistry.” The resulting clusteroluminescent spiropolymers could serve as a potential fluorescent cancer marker and therapeutic agent due to its unique spirocyclic structures and clusterization‐triggered emission properties. Overall, the development of efficient one‐step MCP toward clusteroluminescent polymers is an attractive strategy for preparing new AIE polymers with nonconjugated structures and intriguing functions.…”

Section: One‐step Mcps For In Situ Generation Of Aie Polymersmentioning

confidence: 63%

“…[ 57 ] For example, Dong and co‐workers recently prepared a clusteroluminescent spiropolymer ( P5 , Figure A) based on the facile and catalyst‐free MCP shown in Figure 8C. [ 49 ] MDM2 is an oncogene with strong interaction with the tumor suppressor protein p53 and its primary function is to inhibit the activity of p53. The polymer structure of P5 largely resembles the known inhibitors of MDM2–p53 interaction.…”

Section: Functionalities Of Aie Polymersmentioning

confidence: 99%

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One‐Step Multicomponent Polymerizations for the Synthesis of Multifunctional AIE Polymers

Gao

Wang

et al. 2020

Macromol. Rapid Commun.

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As a new class of functional luminescent materials, polymers with aggregation‐induced emission (AIE) feature attract much attention because of their advantages of efficient solid‐state fluorescence, excellent processability, structural diversity, and multifunctionalities. Among all polymerization methods toward AIE polymers, multicomponent polymerizations (MCPs) exhibit the merits of simple operation, good atom economy, high polymerization efficiency, broad functional‐group tolerance, etc. In this feature article, the recent progress on the development of one‐step MCPs for the synthesis of AIE polymers is highlighted. The representative functionalities of the resulting AIE polymers are illustrated. Perspectives on the challenges and future development directions of this field are also discussed.

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Section: One‐step Mcps For In Situ Generation Of Aie Polymersmentioning

confidence: 63%

Section: Functionalities Of Aie Polymersmentioning

confidence: 99%

One‐Step Multicomponent Polymerizations for the Synthesis of Multifunctional AIE Polymers

Gao

Wang

et al. 2020

Macromol. Rapid Commun.

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“…Therefore, both of these PIFs have potential applications in biological imaging and therapy. [ 52,57,58 ]…”

Section: Resultsmentioning

confidence: 99%

“…Over the years, our group has been committed to the development of catalyst‐free MCCP based on diisocyanides, activated alkynes and various third monomers, and have prepared a series of functional heterocyclic polymers with good solubility and thermal stability, such as polyfurans, [ 48,49 ] poly(iminofuran‐arylene)s, [ 50 ] and spiropolymers. [ 51,52 ] In particular, the poly(iminofuran‐arylene)s have attracted much attention due to their cluster‐triggered emission properties, meanwhile the bromomethyl groups in the side chains provide the possibility for further post functionalization. However, the backbone of poly(iminofuran‐arylene)s contain aromatic groups in each structural unit, which makes the polymers have a certain biotoxicity from degradation metabolites and thus poor biocompatibility, which results in limited biological applications.…”

Section: Introductionmentioning

confidence: 99%

Catalyst‐Free Multicomponent Cyclopolymerizations of Diisocyanides, Activated Alkynes, and 1,4‐Dibromo‐2,3‐Butanedione: a Facile Strategy toward Functional Polyiminofurans Containing Bromomethyl Groups

Zhu

Han

et al. 2020

Macromol. Rapid Commun.

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Polymers containing iminofuran (PIFs) are rarely reported due to the lack of simple and effective synthesis methods. In this work, a novel multicomponent cyclopolymerization (MCCP) of diisocyanides, activated alkynes, and 1,4‐dibromo‐2,3‐butanedione using catalyst‐free one‐pot reactions under mild conditions to prepare PIFs containing bromomethyl groups is reported. PIFs with good solubility and thermal stability are obtained with high Mws (up to 19 600) and good yields (up to 89.5%) under optimized polymerization conditions. The structure of the PIFs is characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The photophysical properties indicate that polymers P1a2b3 and P1c2b3 have cluster‐triggered emission characteristics. Thin films made from PIFs quickly degrade under UV irradiation. Moreover, the obtained polymers are decorated with bromomethyl and carboxylate groups in the side chain, which can be postfunctionalized to prepare multifunctional materials, such as star branched polymers and biomedical carrier materials. Thus, this work not only enriches the field of polymerization based on isocyanates and activated alkynes but also provides a facile strategy toward functional iminofuran polymers.

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“…Similarly, Kim et al. synthesized a heteroatom‐containing spiropolymer P1a2b, which could intrinsically target MDM2 protein that is overexpressed in various cancerous cells [99] . P1a2b exhibited cluster‐triggered emission resulting from strong interaction with the MDM2 protein, which can be used to differentiate cancer cells from normal cells.…”

Section: Turn‐on Theranostics Based On In Situ Aggregationmentioning

confidence: 99%

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

et al. 2020

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Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized and precision medicine. By virtue of the good biocompatibility, outstanding fluorescence property, easy processability and functionalization, promoted photosensitizing efficiency, as well as facile construction of multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible and vigorous vitality in the field of theranostics. Numerous significant breakthroughs and state‐of‐the‐art progression have been witnessed in the past few years. This review highlights the tremendous aggregation‐enhanced superiorities of AIE luminogens (AIEgens) in disease theranostics mainly involving diagnostic imaging (fluorescence and room temperature phosphorescence), therapeutic intervention (photodynamic therapy), and feasibility in construction of multi‐modality theranostics based on the experimental measurements and theoretical simulations. Additionally, the latest and advanced developments of AIEgens in disease theranostics in the aspect of corresponding strategies to design highly effective AIE‐active theranostics through triggering aggregation formation are comprehensively summarized. Moreover, a brief conclusion with the discussion of current challenges and future perspectives in this area is further presented.

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MDM2‐Associated Clusterization‐Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer

Abstract: Figure 4. A-C) The CLSM imaging of HepG2 cells with DCFH/DA; D-F) with P1a2b (10 À5 m) pre-incubation for 30 min then DCFH/DA was added (l ex = 405 nm (blue), l ex = 485 (green)). G) The summary data of cell apoptosis with P1a2b (2.5 10 À5 m) for 24, 48 and 72 h in different cell lines.

Cited by 46 publications

References 28 publications

One‐Step Multicomponent Polymerizations for the Synthesis of Multifunctional AIE Polymers

One‐Step Multicomponent Polymerizations for the Synthesis of Multifunctional AIE Polymers

Catalyst‐Free Multicomponent Cyclopolymerizations of Diisocyanides, Activated Alkynes, and 1,4‐Dibromo‐2,3‐Butanedione: a Facile Strategy toward Functional Polyiminofurans Containing Bromomethyl Groups

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

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