Abstract:Since its discovery about 40 years ago, the transcription factor p53 has turned into the most extensively studied protein in the context of human cancers due to its essential role in promoting tumor suppression. P53 regulates central processes such as the induction of cell cycle arrest, senescence, or apoptosis in response to cellular stresses, thus preventing tumorigenesis in mammals. Being the major negative regulator of p53, the E3 ubiquitin ligase MDM2 is as much of interest to cancer researchers as p53 it… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.