MDCT Linear and Volumetric Analysis of Adrenal Glands: Normative Data and Multiparametric Assessment

Carsin-Vu, Aline; Oubaya, Nadia; Mulé, Sebastien; Janvier, A; Delemer, Brigitte; Soyer, Philippe; Hoeffel, Christine

doi:10.1007/s00330-015-4063-y

Cited by 27 publications

(33 citation statements)

References 44 publications

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“…To date, objective characteristics of adrenal hyperplasia are only poorly specified. In the present study, adrenal hyperplasia was defined according to three main criteria: adrenal limb (medial and lateral) >5 mm (28), adrenal volume above reference values in the general population (as referred in Carsin et al (29)) or the presence of adrenal nodule >10 mm. The presence of hypertension was defined as a systolic blood pressure (SBP) >140 mm Hg, diastolic blood pressure (DBP) ≥90 mmHg and/or patients under any current antihypertensive therapy.…”

Section: Study Protocolmentioning

confidence: 99%

Significant prevalence of NR3C1 mutations in incidentally discovered bilateral adrenal hyperplasia: results of the French MUTA-GR Study

Vitellius

Trabado

Hoeffel

et al. 2018

European Journal of Endocrinology

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Section: Study Protocolmentioning

confidence: 99%

Significant prevalence of NR3C1 mutations in incidentally discovered bilateral adrenal hyperplasia: results of the French MUTA-GR Study

Vitellius

Trabado

Hoeffel

et al. 2018

European Journal of Endocrinology

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“…Normal range for total adrenal volume was calculated based on existing studies as mean ± 1.96 SD. 22,23 variables associated with adrenal volume in univariate analysis with a P-value < 0.1 were considered in the model. Statistical calculations were performed with JMP 13.0.0 software (2016, SAS Institute Inc).…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Distribution of total adrenal volume (logarithmic scale) by age in classic CAH. Normal range for total adrenal volume was calculated based on existing studies as mean ± 1.96 SD …”

Section: Methodsmentioning

confidence: 99%

“…Normal adrenal glands were defined as an adrenal limb junction of 8 mm in the axial plane. Adrenal hyperplasia was defined as volumes greater than published norms: right adrenal gland, 5.7 mL for males and 4.9 mL for females; left adrenal gland, 5.7 mL for males, 4.4 mL for females [21][22][23]. Atrophy designation per radiologist was defined as 'thinner than the adjacent width of the limb of the diaphragm'.Males underwent a testicular ultrasound by a trained sonographer and radiologist using a linear, high-frequency, 7.5-MHz transducer in the transverse and longitudinal planes, with color flow Doppler.…”

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Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia

El‐Maouche

Hannah‐Shmouni

Mallappa

et al. 2019

Clinical Endocrinology

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Objective Adrenonodular hyperplasia and tumour formation are potential long‐term complications of congenital adrenal hyperplasia (CAH) with little known regarding the clinical implications. Our aim was to describe volumetric adrenal morphology and determine the association between radiological findings and comorbidities in adults with classic CAH. Design This was a cross‐sectional study of 88 patients (mean age 29.2 ± 13 years, 47 females) with classic CAH seen in a tertiary referral centre. Methods CT imaging, performed at study entry or when reaching adulthood, was used to create 3‐dimensional volumetric models. Clinical, genetic and hormonal evaluations were collected and correlated with adrenal morphology and tumour formation. Results Over one‐third of the cohort was obese. 53% had elevated 17‐OH‐progesterone or androstenedione; and 60% had adrenal hyperplasia. Tumours included 11 myelolipomas, 8 benign adrenocortical adenomas, 1 pheochromocytoma and 50% of men had testicular adrenal rest tissue. CAH patients with adrenal hyperplasia had significantly higher number of comorbidities than those with morphologically normal adrenals (P = 0.03). Variables that positively correlated with adrenal volume included hypogonadal/oligomenorrhoeic status, hypertension, androstenedione, aldosterone, and triglyceride levels, and in women, low HDL and insulin resistance. Elevated aldosterone was observed in a subset of patients with simple virilizing CAH. Conclusions Adrenocortical hyperplasia is associated with a number of comorbidities, especially hypogonadism. Aldosterone production associated with adrenal enlargement may play a role in the development of metabolic risk factors. Further studies are needed to assess the long‐term impact of the excess adrenal steroid milieu associated with adrenal enlargement to develop improved management strategies for CAH.

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Association of MRI‐based adrenal gland volume and impaired glucose metabolism in a population‐based cohort study

Askani

Rospleszcz

Lorbeer

et al. 2022

Diabetes Metabolism Res

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Objectives:The aim of this study was to assess adrenal gland volume by using magnetic resonance imaging (MRI) and to study its role as an indirect marker of impaired glucose metabolism and hypothalamic-pituitary-adrenal (HPA) axis activation in a population-based cohort.Methods: Asymptomatic participants were enrolled in a nested case-control study and underwent a 3-T MRI, including T1w-VIBE-Dixon sequences. For the assessment of adrenal gland volume, adrenal glands were manually segmented in a blinded fashion. Impaired glucose metabolism was determined using fasting glucose and oral glucose tolerance test. Cardiometabolic risk factors were also obtained. Inter-and intrareader reliability as well as univariate and multivariate associations were derived.Results: Among 375 subjects included in the analysis (58.5% male, 56.1 � 9.1 years), 25.3% participants had prediabetes and 13.6% had type 2 diabetes (T2DM). Total adrenal gland volume was 11.2 � 4.2 ml and differed significantly between impaired glucose metabolism and healthy controls with largest total adrenal gland volume in

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MDCT Linear and Volumetric Analysis of Adrenal Glands: Normative Data and Multiparametric Assessment

Cited by 27 publications

References 44 publications

Significant prevalence of NR3C1 mutations in incidentally discovered bilateral adrenal hyperplasia: results of the French MUTA-GR Study

Significant prevalence of NR3C1 mutations in incidentally discovered bilateral adrenal hyperplasia: results of the French MUTA-GR Study

Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia

Association of MRI‐based adrenal gland volume and impaired glucose metabolism in a population‐based cohort study

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