MDCT Angiography of the Pulmonary Arteries: Influence of Iodine Flow Concentration on Vessel Attenuation and Visualization

Schoellnast, Helmut; Deutschmann, Hannes; Fritz, G. A.; Stessel, U.; Schaffler-Schaden, Dagmar; Tillich, Manfred

doi:10.2214/ajr.184.6.01841935

Cited by 58 publications

(36 citation statements)

References 15 publications

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“…If a comparison between our study and the studies referenced previously is attempted, our result supports the results of the MDCT angiography study of pulmonary arteries 13 and the coronary angiography study. 14 In all 3 studies, the study design was very similar, injection rate and total iodine dose were constant, and the iodine concentration was the only variable studied.…”

Section: Discussionsupporting

confidence: 88%

“…In a study of multidetector row CT (MDCT) angiography of pulmonary arteries, 2 groups of patients were studied. 13 A low-concentration group received 120 mL of 300-mg/mL iohexol, and the high concentration group, 90 mL of 400-mg/mL iomeprol at a constant injection rate of 4 mL/s. An otherwise identical imaging protocol was used in both groups, and in both groups, the total iodine dose administered was the same.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increasing Contrast Agent Concentration Improves Enhancement in First-Pass CT Perfusion

Silvennoinen¹,

Hamberg²,

Valanne³

et al. 2007

American Journal of Neuroradiology

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Increasing Contrast Agent Concentration Improves Enhancement in First-Pass CT Perfusion

Silvennoinen¹,

Hamberg²,

Valanne³

et al. 2007

American Journal of Neuroradiology

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“…As poor vascular enhancement may affect diagnostic accuracy, it may be necessary to adjust the imaging protocols for pregnant patients undergoing CTPA. Arterial attenuation may be increased by raising the contrast flow rate or by using a contrast medium with a high iodine concentration [37,38].…”

Section: Discussionmentioning

confidence: 99%

Does pregnancy affect vascular enhancement in patients undergoing CT pulmonary angiography?

et al. 2008

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The aim of this study was to evaluate whether pregnancy affects contrast enhancement within the pulmonary arteries during computed tomography pulmonary angiography (CTPA). This was a retrospective analysis of the CTPA examinations of 16 pregnant and 16 non-pregnant female patients, suspected of having an acute pulmonary embolus (PE), during the same time period. Pulmonary vascular enhancement was evaluated by measuring the CT density within the pulmonary arteries. In a blinded evaluation, subjective grading of contrast enhancement within the pulmonary arteries was also performed. There was a significant difference in arterial enhancement between the two groups, with pregnant patients having a mean pulmonary arterial density 112 HU less than patients in the control group [mean attenuation of 259.79 +/- 59.31 HU in pregnant patients versus 371.88 +/- 60.63 HU in non-pregnant patients (p < 0.001)]. The mean subjective pulmonary arterial enhancement score in the pregnant group was 8.19 +/- 2.51 versus 13.69 +/- 3.07 in the control group (p < 0.001). Pregnant women undergoing CTPA have significantly decreased pulmonary arterial enhancement compared to non-pregnant patients, probably due to the increase in cardiac output in pregnancy. We may need to reconsider how we perform CTPA in this group in order to ensure adequate opacification for diagnosis.

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“…However, optimal pulmonary artery contrast material (CM) enhancement is one main parameter that is crucial for a sufficient depiction of pulmonary emboli [4], as poor contrast enhancement may limit the informative value of MDCTA [3,5].…”

Section: Introductionmentioning

confidence: 99%

MDCT angiography of the pulmonary arteries: intravascular contrast enhancement does not depend on iodine concentration when injecting equal amounts of iodine at standardized iodine delivery rates

et al. 2008

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To compare the impact of iodine concentration using two different contrast materials (CM) at standardized iodine delivery rate (IDR) and overall iodine load in 16-multidetector-row-CT-angiography (MDCTA) of the pulmonary arteries of 192 patients with known or suspected pulmonary embolism. One hundred three patients (group A) received 148 ml of a CM containing 300 mg iodine/ml (Ultravist 300, BayerScheringPharma) at a flow rate of 4.9 ml/s. Eighty-nine patients (group B) received 120 ml of a CM with a concentration of 370 mg iodine/ml (Ultravist 370) at a flow rate of 4.0 ml/s, resulting in a standardized IDR (approximately 1.5 gI/s) and the same overall amount of iodine (44.4 g). Both CM injections were followed by a saline chaser. Mean density values were determined in the pulmonary trunk, the ascending and the descending aorta, respectively. Applying repeated-measures ANOVA, no statistically significant differences between both MDCTA protocols were found (p = 0.5790): the mean density in the pulmonary trunk was 355 +/- 116 Hounsfield Units (group A) and 358 +/- 115 (group B). The corresponding values for the ascending and descending aorta were 295 +/- 79 (group A) and 284 +/- 65 (group B) as well as 272 +/- 71 and 262 +/- 70. In conclusion, the use of standardized IDR and overall iodine load provides comparable intravascular CM density in pulmonary 16-MDCTA for delivering contrast materials with different iodine concentrations.

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MDCT Angiography of the Pulmonary Arteries: Influence of Iodine Flow Concentration on Vessel Attenuation and Visualization

Abstract: Use of a high flow concentration of iodine in MDCT angiography of the pulmonary arteries significantly increases attenuation of the pulmonary arteries, thereby improving visualization of subsegmental pulmonary arteries.

Cited by 58 publications

References 15 publications

Increasing Contrast Agent Concentration Improves Enhancement in First-Pass CT Perfusion

Increasing Contrast Agent Concentration Improves Enhancement in First-Pass CT Perfusion

Does pregnancy affect vascular enhancement in patients undergoing CT pulmonary angiography?

MDCT angiography of the pulmonary arteries: intravascular contrast enhancement does not depend on iodine concentration when injecting equal amounts of iodine at standardized iodine delivery rates

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