MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma

Yue, Hongya; Zhu, Jin; Xie, Shugang; Li, Fangfang; Xu, Qun

doi:10.1016/j.biopha.2016.03.002

Cited by 20 publications

(17 citation statements)

References 30 publications

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“…Since MDC1 was identified as a tumor-suppressor gene (37), in glioma, there was a positive relationship between the lncRNA MDC1-AS and the antisense transcript of MDC1. Moreover, MDC1-AS can not block the cell cycle of glioma cells without MDC1 (38). However, the underlying mechanism of lncRNAs and the clinical and prognosis value of their expression remain elusive.…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Tian

2017

Int J Biol Markers

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Section: Discussionmentioning

confidence: 99%

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Tian

2017

Int J Biol Markers

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“…The antisense transcript of MDC1, MDC1-antisense RNA (MDC1-AS), was recently identified as a novel LncRNA in bladder cancer ( 16 ). Another study demonstrated that the relative transcript level of MDC1-AS was decreased in bladder cancer and glioma ( 17 ). In addition, overexpression of MDC1-AS promoted human glioma cell proliferation and shifted the cell cycle in an MDC1-dependent manner ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

“…Another study demonstrated that the relative transcript level of MDC1-AS was decreased in bladder cancer and glioma ( 17 ). In addition, overexpression of MDC1-AS promoted human glioma cell proliferation and shifted the cell cycle in an MDC1-dependent manner ( 17 ). However, the molecular mechanism underlying this effect and the role of MDC1-AS in gastric cancer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA MDC1‑AS inhibits human gastric cancer cell proliferation and metastasis through an MDC1‑dependent mechanism

et al. 2017

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Gastric cancer is the third leading cause of cancer-associated mortality worldwide and is one of the most common malignancies in China. However, the molecular mechanisms underlying the tumorigenesis of gastric cancer remain largely unclear. Long non-coding (Lnc)RNAs have been demonstrated to serve significant roles in the tumorigenesis of various types of cancer. The present study aimed to explore the role of the LncRNA mediator of DNA damage checkpoint protein 1-antisense RNA (MDC1-AS), the antisense transcript of MDC1, in human gastric cancer. The results revealed that the expression of MDC1-AS in human gastric cancer was significantly suppressed in vivo and in vitro. In addition, overexpression of MDC1-AS in the poorly differentiated gastric cancer cell line MKN28 significantly inhibited cell proliferation and metastasis, while the knockdown of MDC1-AS in well-differentiated MKN45 gastric cancer cells significantly increased proliferation and metastasis. The knockdown of MDC1 relieved the inhibitory effect of MDC1-AS on MKN28 cell proliferation and metastasis, while the overexpression of MDC1 attenuated the stimulatory effect of MDC1-AS knockdown in MKN45 cells. Thus, the present study demonstrated that MDC1-AS had an inhibitory on gastric tumorigenesis through an MDC1-dependent mechanism. This indicates that MDC1-AS is a potential novel therapeutic target for the diagnosis and treatment of human gastric cancer in the clinic.

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“…For example, the upregulated PCNA‐AS1 was proven to promote tumor growth in hepatocellular carcinoma through regulating the expression of PCNA [Yuan et al, ]. Other antisense lncRNAs, such as MDC1‐AS , FGFR3‐AS1 , and HNF1A‐AS1 [Yue et al, ; Sun et al, ; Yang et al, ], have also been reported to get involved in the initiation and progression of human cancers. However, the number of antisense lncRNAs which have been functionally characterized in CRC are quite limited [Nakano et al, ].…”

Section: Introductionmentioning

confidence: 99%

Association between genetic variants in the promoter region of a novel antisense long noncoding RNA RP11‐392P7.6 and colorectal cancer risk

Jin

Ding

et al. 2017

Environ and Mol Mutagen

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There is a widespread occurrence of antisense transcripts' regulation on cancer-related genes in cancer biology. RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D, which has been found recently. The aim of this study was to investigate the associations of tagSNPs in the promoter region of RP11-392P7.6 with the risk of colorectal cancer. We conducted a two-stage case-control study, with a discovery set (320 cases and 319 controls) and a validation set (501 cases and 538 controls). Four tagSNPs (rs1531970, rs1642199, rs4763903, and rs10845671) were selected based on 1000 Genomes Project data and genotyped by using the Sequenom MassARRAY genotyping platform. In the discovery set, three tagSNPs (rs1642199, rs4763903, and rs10845671) were revealed promising associations with the risk of colorectal cancer, among which the rs10845671 variants were further replicated in the validation set (OR = 1.47, 95% CI = 1.10-1.20 in heterozygote codominant model; OR = 1.38, 95% CI = 1.04-1.83 in dominant model). When combined the two sets, the above positive associations remained unchanged. Rs10845671 was found to be associated with an increased risk of colorectal cancer (OR = 1.43, 95% CI = 1.14-1.81 in heterozygote codominant model; OR = 1.35, 95% CI = 1.08-1.69 in dominant model). These findings indicate that rs10845671 may contribute to the susceptibility to colorectal cancer and be a candidate biomarker for colorectal cancer risk prediction. Environ. Mol. Mutagen. 58:434-442, 2017. © 2017 Wiley Periodicals, Inc.

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MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma

Cited by 20 publications

References 30 publications

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors

Long non‑coding RNA MDC1‑AS inhibits human gastric cancer cell proliferation and metastasis through an MDC1‑dependent mechanism

Association between genetic variants in the promoter region of a novel antisense long noncoding RNA RP11‐392P7.6 and colorectal cancer risk

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