2005
DOI: 10.1111/j.1610-0378.2005.04089.x
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MCTD – Mixed Connective Tissue Disease

Abstract: Mixed connective tissue disease is a disease entity characterized by overlapping symptoms of lupus erythematosus (LE), systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM) and rheumatoid arthritis (RA). Diagnostic criteria include high titers of antibodies against U1RNP as well as the presence of at least 3 of 5 of the following clinical features: edema of hands, synovitis, myositis, Raynaud phenomenon and acroscierosis. In terms of the pathogenesis, genetic as well as infectious (viral) factors appe… Show more

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Cited by 4 publications
(1 citation statement)
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“…As previously reported (Luyckx et al, 2005; Ball et al, 2007; Kumar et al, 2009), elevated levels of anti-dsDNA, anti-Sm, red blood cell casts, thrombocytopenia, non-erosive arthritis as well as pleuritic and/or pericarditis are present in clear SLE cases. By contrast, unclear patients exhibit elevated frequencies of synovitis and tenderness in two or more joints, pericarditis and leukopenia ( p ≤ 0.01) as has been previously reported (Haustein, 2005). The proposed reduced models from currently used classification criteria sets highlight clinical and molecular features that help unclear SLE and MCTD segregation ( Table 3 ).…”
Section: Discussionsupporting
confidence: 79%
“…As previously reported (Luyckx et al, 2005; Ball et al, 2007; Kumar et al, 2009), elevated levels of anti-dsDNA, anti-Sm, red blood cell casts, thrombocytopenia, non-erosive arthritis as well as pleuritic and/or pericarditis are present in clear SLE cases. By contrast, unclear patients exhibit elevated frequencies of synovitis and tenderness in two or more joints, pericarditis and leukopenia ( p ≤ 0.01) as has been previously reported (Haustein, 2005). The proposed reduced models from currently used classification criteria sets highlight clinical and molecular features that help unclear SLE and MCTD segregation ( Table 3 ).…”
Section: Discussionsupporting
confidence: 79%