MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion ofBorrelia burgdorferi
Sajith Raghunandanan,
Kai Zhang,
Zhang Yan
et al.
Abstract:Borrelia(orBorreliella)burgdorferi, the causative agent of Lyme disease, is a motile and invasive zoonotic pathogen, adept at navigating between its arthropod vector and mammalian host. While motility and chemotaxis are well established as essential for its enzootic cycle, the function of methyl-accepting chemotaxis proteins (MCPs) in the infectious cycle ofB. burgdorferiremains unclear. In this study, we demonstrate that MCP5, one of the most abundant MCPs inB. burgdorferi, is differentially expressed in resp… Show more
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