MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Liu, Mu-N; Tsai, Shih‐Jen; Yeh, Heng Liang; Wu, Chih‐Ching; Lin, Ching Po

doi:10.1080/13811118.2019.1649772

Cited by 7 publications

(9 citation statements)

References 29 publications

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“…Consequently, we performed a sensitivity analysis on the high-quality studies (quality score≥7.0; redpoint score ≤18.0) and compared those with a low quality (quality score≤4.0; redpoint score>18.0). ESF 2 Figure 2 shows the meta-analysis performed on the 13 high-quality studies 44,46,52,53,55,64,66,69,70,72,84,91,93 (SMD: 0.407; 95%CI: 0.203; 0.611; τ 2 =0.092) and 5 low-quality studies 39,73,79,89,92 (SMD: 0.129; 95%CI: 0.014; 0.0.243; τ 2 =0.005) when comparing SB to controls. This difference between high-and low-quality studies was significant (χ 2 =5.444, df=1, p=0.020).…”

Section: Meta-analysis Of the Primary Outcome: Ioandns Profilementioning

confidence: 99%

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Vasupanrajit¹,

Jirakran²,

Tunvirachaisakul³

et al. 2021

Preprint

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A meta-analysis showed a significant association between activated immune-inflammatory and nitro-oxidative (IO&NS) pathways and suicide attempts (SA). There are no data whether suicidal ideation (SI) is accompanied by activated IO&NS pathways and whether there are differences between SA and SI. The current study searched PubMed, Google Scholar, and Web of Science, for articles published from inception until May 10, 2021, and systematically reviewed and meta-analyzed the association between recent SA/SI (< 3 months) and IO&NS biomarkers. We included studies which compared psychiatric patients with and without SA and SI and controls (either healthy controls or patients without SA or SI) and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence intervals (CI). Our search included 59 studies comprising 4.034 SA/SI cases and 12.377 controls. Patients with SA/SI showed activated IO&NS pathways (SMD: 0.299; CI: 0.200; 0.397) when compared to controls. The immune profiles were more strongly associated with SA than with SI, particularly when compared to healthy controls, as evidenced by activated IO&NS pathways (SMD: 0.796; CI: 0.503; 1.089), an immune-inflammatory response (SMD: 1.409; CI: 0.637; 1.462), inflammation (SMD: 1.200; CI: 0.584; 1.816), and neurotoxicity (SMD: 0.904; CI: 0.431; 1.378). The effects sizes of the IO&NS, immune-inflammatory response and inflammatory profile were significantly greater in SA than in SI. In conclusion: increased neurotoxicity due to inflammation and nitro-oxidative stress and lowered neuroprotection may explain at least in part why psychiatric patients show increased SA and SI. The IO&NS pathways are more pronounced in recent SA than in SI.

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Section: Meta-analysis Of the Primary Outcome: Ioandns Profilementioning

confidence: 99%

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Vasupanrajit¹,

Jirakran²,

Tunvirachaisakul³

et al. 2021

Preprint

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“…Study sample size ranged from 24[ 33 ] to 654232[ 34 ], with a mean of 22211.77 (SD: 109023.38). Male/female ratio was also quite diverse across studies, with a percentage of female participants ranging from 0[ 2 , 35 , 36 ] to 74%[ 37 ]. Mean age fluctuated between studies from 69.51[ 38 ] to 84.37 years[ 39 ], with an overall mean age of 72.5 (SD: 0.5) years.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies (60%) selected examined suicidal ideation outcome[ 3 , 10 , 20 - 22 , 25 , 36 , 38 - 52 ]. On the other hand, suicide attempt was assessed in 40% of studies[ 2 , 3 , 21 , 35 , 37 , 41 , 44 , 52 - 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this vein, Coupland et al [ 55 ] observed a higher probability to show suicide behaviour in patients under antidepressant treatment. Finally, the severity of depressive symptoms was strongly associated with higher suicide behaviour across studies[ 36 , 40 , 42 , 51 , 60 ]. Meeks et al [ 49 ] highlighted the relationship between sleep difficulty and suicidal ideation.…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for suicidal behaviour in late-life depression: A systematic review

Fernandez-Rodrigues¹,

Sanchez-Carro²,

Lagunas³

et al. 2022

WJP

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BACKGROUND Suicide is a leading cause of preventable death worldwide, with its peak of maximum incidence in later life. Depression often puts an individual at higher risk for suicidal behaviour. In turn, depression deserves particular interest in old age due to its high prevalence and dramatic impact on health and wellbeing. AIM To gather integrated evidence on the potential risk factors for suicide behaviour development in depressive older adults, and to examine the effects of depression treatment to tackle suicide behaviour in this population. METHODS A systematic review of empirical studies, published from 2000 onwards, was conducted. Suicidal behaviour was addressed considering its varying forms ( i.e. , wish to die, ideation, attempt, and completed suicide). RESULTS Thirty-five papers were selected for review, comprising both clinical and epidemiological studies. Most of studies focused on suicidal ideation (60%). The studies consistently pointed out that the risk was related to depressive episode severity, psychiatric comorbidity (anxiety or substance use disorders), poorer health status, and loss of functionality. Reduced social support and loneliness were also associated with suicide behaviour in depressive older adults. Finally, the intervention studies showed that suicidal behaviour was a robust predictor of depression treatment response. Reductions in suicidal ideation were moderated by reductions in risk factors for suicide symptoms. CONCLUSION To sum up, common and age-specific risk factors seem to be involved in suicide development in depressive older adults. A major effort should be made to tackle this serious public health concern so as to promote older people to age healthily and well.

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“…Consequently, we performed a sensitivity analysis on the high-quality studies (quality score ≥7.0; redpoint score ≤ 18.0) and compared those with lower quality studies (quality score ≤4.0; redpoint score >18.0). ESF 2 Figure 2 shows the metaanalysis performed on the 13 high-quality studies 44,46,52,53,55,64,66,69,70,72,84,91,93 (SMD: 0.407; 95%CI: 0.203; 0.611; τ 2 =0.092) and 5 low-quality studies 39,73,79,89,92 (SMD: 0.129; 95%CI: 0.014; 0.0.243; τ 2 =0.005) when comparing SB to controls. This difference between high-and low-quality studies was significant (χ 2 =5.444, df=1, p=0.020).…”

Section: Meta-analysis Of the Primary Outcome: Ioandns Profilementioning

confidence: 99%

Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis

Vasupanrajit

Jirakran

Tunvirachaisakul

et al. 2021

Preprint

View full text Add to dashboard Cite

A meta-analysis showed a significant association between activated immune-inflammatory and nitro-oxidative (IO&NS) pathways and suicide attempts (SA). There is no data on whether suicidal ideation (SI) is accompanied by activated IO&NS pathways and whether there are differences between SA and SI. The current study searched PubMed, Google Scholar, and Web of Science, for articles published from inception until May 10, 2021, and systematically reviewed and meta-analyzed the association between recent SA/SI (< 3 months) and IO&NS biomarkers. We included studies which compared psychiatric patients with and without SA and SI and controls (either healthy controls or patients without SA or SI) and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence intervals (CI). Our search included 59 studies comprising 4.034 SA/SI cases and 12.377 controls. Patients with SA/SI showed activated IO&NS pathways (SMD: 0.299; CI: 0.200; 0.397) when compared to controls. The immune profiles were more strongly associated with SA than with SI, particularly when compared to healthy controls, as evidenced by activated IO&NS (SMD: 0.796; CI: 0.503; 1.089), immune (SMD: 1.409; CI: 0.637; 1.462), inflammatory (SMD: 1.200; CI: 0.584; 1.816), and neurotoxic (SMD: 0.904; CI: 0.431; 1.378) pathways. The effects sizes of the IO&NS, immune and inflammatory profiles were significantly greater in SA than in SI. In conclusion: increased neurotoxicity due to inflammation and nitro-oxidative stress and lowered neuroprotection explains at least in part why psychiatric patients show increased SA and SI. The IO&NS pathways are more pronounced in recent SA than in SI.

show abstract

MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Cited by 7 publications

References 29 publications

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Risk factors for suicidal behaviour in late-life depression: A systematic review

Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis

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