MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

Abstract

ABSTRACT. Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and Korean populations. To explore the role of the MCP-1 gene in the susceptibility to PTB in a North Chinese population, we evaluated the association between MCP-1 -2518A/G gene polymorphisms and the risk for tuberculosis. Polymerase chain reaction amplification of genomic DNA followed by restriction fragment length polymorphism analysis was used. There was a significant increase in the frequency of the GG genotype of MCP-1 -2518 in 136 patients with PTB compared to that in 152 healthy controls (P = 0.008, c 2 = 7.133, odds ratio = 1.96). Similarly, the frequencies of the A/G alleles in the 2 groups differed; the frequency of allele G was higher in patients with PTB (P = 0.011, c 2 = 6.428, odds ratio = 1.536). In conclusion, the -2518A/G polymorphism in the MCP-1 gene G.L. Shi et al. 4036©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4035-4040 (2015) was found to be associated with an increased susceptibility to PTB in a North Chinese population.

Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients

“…Recently, accumulating evidences demonstrated that MCP-1 genetic variations within the regulatory regions could make patients susceptible to certain inflammation-related diseases, infection and sepsis by altering MCP-1 expression levels. [ 32 – 34 ] Furthermore, a number of studies demonstrated that inhibition or specific antagonism of MCP-1 could decrease the septic response and are beneficial to survival in mouse models of sepsis. [ 35 – 37 ] These results confirmed that MCP-1 played an important role in the pathomechanisms of immune dysregulation and maybe a promising potential therapeutic target for correcting the immune disorder of severe trauma.…”

Impact of the MCP-1-2518A>G polymorphism on COVID-19 severity in the Iranian population: A case-control study

“…Many infectious diseases and inflammatory disorders are associated with MCP-1-2518A>G polymorphism [18] , [24] , [25] , [26] . In another study, like the present study, this polymorphism was investigated in SARS-CoV-2 infection using the GWAS method.…”

Association of MCP-1 rs1024611 polymorphism with diabetic foot ulcers

“…Blood samples were used for genomic DNA extraction via DNA extraction kit (Tiangen, Beijing, China). The amplification of rs1024611 SNP [ 19 ] was accorded with the previous study using polymerase chain reaction (PCR). Finally, PCR products were sequenced by ABI 3730XL analyzer (Applied Biosystems, Foster City, CA).…”